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Structural Biology of sulfotransferase and glycosyltrans

Structural Biology of sulfotransferase and glycosyltrans
磺基转移酶和糖基反式的结构生物学
批准号：
7007467
负责人：
MASAHIKO NEGISHI
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7007467
关键词：
X ray crystallographyenvironmental toxicologyenzyme activityenzyme structureenzyme substrate complexglucuronosyltransferaseglycosyltransferasehalobiphenyl /halotriphenyl compoundhemagglutininheparan sulfatemicrocalorimetrymucopolysaccharidesprotein protein interactionsite directed mutagenesisstructural biologysulfationsulfotransferase

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英文摘要
Cytosolic STs sulfate xenochemicals for detoxification and secretion and also sulfate biological signal molecules such as steroid hormones and bioamines for inactivation and/or storage. Certain sulfated products become carcinogenic. Golgi-membrane STs display high specificity to sulfate distinct sites of polysaccharides. Various glycosyltransferases synthesize polysaccharides and provide STs with substrates. Our research objectives are to eluciadte structure and function of these enzymes. For this, we have used bacterial expression system to produce a large amount of recombinant proteins, have crystallized them, and have solved their 3-dimensional structures.
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