Outcomes Research in Rheumatic Diseases: A Mentoring Program

风湿性疾病的结果研究：指导计划

• 批准号: 7258774
• 负责人: Maria E Suarez-Almazor
• 金额: $ 15.73万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7258774
• 关键词: Outcomes; Research; Rheumatic; Diseases; Mentoring

DESCRIPTION (provided by applicant): The aim of this application is to develop a patient-oriented mentoring and research program in rheumatic diseases at Baylor College of Medicine. By establishing a comprehensive methodological and content-based program we will provide mentorship and research opportunities to students, fellows, and junior physician and PhD Faculty interested in pursuing independent research careers in Outcomes Research and Clinical Epidemiology in rheumatic diseases. The proposed program will be interdisciplinary in nature and will be facilitated by the interaction between physicians and scientists in the Sections of Health Services Research and Immunology, Allergy and Rheumatology at Baylor College of Medicine. The applicant has MD and PhD degrees and is a rheumatologist and clinical epidemiologist. She is Faculty in both Baylor Sections. Her research interests are in the outcomes of rheumatic diseases, particularly rheumatoid arthritis and osteoarthritis, with an emphasis on the effectiveness of care in these disorders, patient and physician preferences and decision-making processes, and measurement of patient reported outcome in these diseases. The proposed program is based on current grants held by the applicant and the planned continuation projects arising from this research, including: (1) Decision-Making in Joint Replacement - Variations in the use of joint replacement are well documented. The aim of the study is to identify patient and physician determinants of this variation, and to develop evidence-based decision aids to assist patients in their decisions. (2) Treatment Adherence in Patients with Rheumatic Disease - We are conducting a prospective cohort study to evaluate treatment adherence in patients with rheumatoid arthritis and systemic lupus. Preliminary data shows that adherence is problematic. The results of the study will provide the groundwork for an evaluation of a multifaceted intervention to improve adherence. (3) Cognitive Determinants of Outcomes in Total Knee Replacement- Approximately 20-25% of patients undergoing knee replacement are not satisfied with the results, despite technical success. We are evaluating the clinical and psychosocial determinants of this dissatisfaction in a cohort of patients undergoing knee replacement. There is evidence that this may be related to deficient rehabilitation within the first three months after surgery. At the end of the study, we are planning to develop, implement and evaluate a perioperative intervention designed to improve outcomes through goal-setting and various other cognitive techniques. (4) Impact of Patient-Provider Interaction in the Response to Acupuncture in Patients with Knee Osteoarthritis - This is a randomized controlled trial comparing acupuncture and sham acupuncture in the treatment of knee osteoarthritis. The main aim of the study is to evaluate the effects of different patient-provider communication styles on acupuncture and placebo responses.

描述(由申请者提供)：本申请的目的是在贝勒医学院开发一个以患者为导向的风湿病指导和研究计划。通过建立一个全面的方法和基于内容的计划，我们将为有兴趣从事风湿病结果研究和临床流行病学方面的独立研究生涯的学生、研究员、初级医生和博士生提供指导和研究机会。拟议的计划将是跨学科的，并将通过贝勒医学院卫生服务研究和免疫学、过敏和风湿病学部分的医生和科学家之间的互动来促进。申请人拥有医学博士学位，是风湿病专家和临床流行病学家。她是两个贝勒分部的教员。她的研究兴趣是风湿性疾病的结果，特别是类风湿性关节炎和骨关节炎，重点是这些疾病的护理有效性，患者和医生的偏好和决策过程，以及患者报告的这些疾病结果的衡量。拟议方案基于申请者目前持有的赠款和这项研究产生的计划续展项目，包括： (1)关节置换术的决策--关节置换术中的各种变化都有很好的记录。这项研究的目的是确定这种变异的患者和医生的决定因素，并开发基于证据的决策辅助工具，以帮助患者做出决定。 (2)风湿病患者的治疗依从性-我们正在进行一项前瞻性队列研究，以评估类风湿性关节炎和系统性红斑狼疮患者的治疗依从性。初步数据显示，坚持是有问题的。这项研究的结果将为评估改善依从性的多方面干预提供基础。 (3)全膝关节置换术结果的认知决定因素--尽管技术上取得了成功，但约有20%-25%的膝关节置换术患者对结果并不满意。我们正在评估膝关节置换术患者中这种不满的临床和心理社会决定因素。有证据表明，这可能与术后前三个月内康复不足有关。在研究结束时，我们计划开发、实施和评估围术期干预措施，旨在通过目标设定和各种其他认知技术改善结果。 (4)针灸对膝关节骨性关节炎患者针灸疗效的影响--这是一项比较针灸和假针灸治疗膝骨性关节炎的随机对照试验。这项研究的主要目的是评估不同的患者-提供者沟通方式对针灸和安慰剂反应的影响。