Outcomes Research in Rheumatic Diseases: A Mentoring Program

描述(由申请人提供)：本次K24续签申请的总体目标是在整个德克萨斯州医疗中心(德克萨斯州休斯敦)继续开发和实施以患者为中心的风湿病指导和研究计划。我是一名风湿学家，拥有流行病学博士学位，对肌肉骨骼疾病的临床流行病学和结果研究感兴趣，包括比较有效性、患者和医生的偏好、决策过程和患者报告结果的测量。在过去的4年里，在K24奖项提供的保护时间内，我建立了一个全面的方法和基于内容的计划，为有兴趣从事风湿病结果研究的独立研究生涯的学生、研究员、初级医生和博士生提供指导和研究机会。该项目涵盖了休斯顿德克萨斯医疗中心的各种学术机构。拟议的继续项目是跨学科的，重点是扩大肌肉骨骼疾病领域的临床研究机会和指导。特别令人感兴趣的是对风湿病患者和各种并发症(如癌症)患者的研究。我在德克萨斯大学MD安德森癌症中心风湿科工作。该计划与贝勒医学院的免疫学、过敏症和风湿病学相关。我们共享一个联合临床奖学金计划，此外，我还指导贝勒及其附属退伍军人事务医疗中心的教职员工和研究员。我还与休斯顿的德克萨斯大学健康科学中心的另一个风湿学学术项目密切合作。拟议的计划是基于我目前的拨款和这项研究产生的计划中的后续项目，包括：(1)由医疗保健研究和质量机构(AHRQ)资助的治疗教育和研究中心；(2)iAdapt，这是ARRA的一个项目，审查与肌肉骨骼状况有关的患者决策辅助的开发和实施；(3)对乙酰氨基酚的利用和毒性，由AHRQ资助的R18赠款；以及(4)癌症患者骨质疏松的护理质量。此外，我正在继续我之前的工作，其中包括我的许多学员，在风湿病的治疗坚持和全膝关节置换的结果方面。这些项目是由R01拨款资助的，我目前正在为这些研究进行竞争性续签。这些项目是拟议的指导和研究计划的基础。K24奖项将为我提供受保护的时间，让我继续指导休斯顿风湿病学术界的其他人，并帮助他们在以患者为导向的风湿病研究中建立独立的职业生涯。

DESCRIPTION (provided by applicant): The overall goal of this K24 renewal application is to continue to develop and implement a patient-oriented mentoring and research program in rheumatic diseases throughout the Texas Medical Center (Houston, TX). I am a rheumatologist with a PhD degree in epidemiology, and an interest in clinical epidemiology and outcomes research in musculoskeletal disorders, including comparative effectiveness, patient and physician preferences, decision-making processes, and measurement of patient reported outcomes. During the past 4 years, with the protected time offered by the K24 award, I have established a comprehensive methodological and content- based program providing mentorship and research opportunities to students, fellows, and junior physician and PhD faculty interested in pursuing independent research careers in outcomes research in rheumatic diseases. The program has encompassed various academic institutions in the Houston Texas Medical Center. The proposed continuing program is interdisciplinary, and focuses in expanding clinical research opportunities and mentoring in the field of musculoskeletal disease. Of particular interest is research in patients with rheumatic disease and various comorbidities such as cancer. I am based in the Section of Rheumatology at the University of Texas MD Anderson Cancer Center. This program is linked to the Section of Immunology, Allergy and Rheumatology at Baylor College of Medicine. We share a joint clinical fellowship program and, in addition, I also mentor Faculty and fellows at Baylor and its affiliated Veteran Affairs Medical Center. I also closely collaborate with the other academic rheumatology program in Houston, at the University of Texas Health Sciences Center. The proposed program is based on my current grants and the planned continuation projects arising from this research, including: (1) Center for Education and Research on Therapeutics, funded by the Agency for Healthcare Research and Quality (AHRQ); (2) iADAPT, an ARRA project examining the development and implementation of patient decision aids with respect to musculoskeletal conditions; (3) Utilization and toxicity of acetaminophen, a R18 grant funded by AHRQ; and (4) Quality of care for osteoporosis in patients with cancer. In addition, I am continuing my previous work, which has included many of my mentees, in treatment adherence in the rheumatic diseases, and outcomes of total knee replacement. These projects were funded by R01 grants and I am currently working on competitive renewals for these studies. These projects are the basis for the proposed mentoring and research program. The K24 award will provide me with protected time to continue to mentor others in the Houston rheumatology academic community and help them establish their independent careers in patient-oriented research in rheumatic diseases.