Outcomes Research in Rheumatic Diseases: A Mentoring Program

描述（由申请人提供）：本次K24更新申请的总体目标是在整个德克萨斯州医学中心（德克萨斯州休斯顿）继续开发和实施以患者为导向的风湿性疾病指导和研究计划。我是一名风湿病学家，拥有流行病学博士学位，对肌肉骨骼疾病的临床流行病学和结果研究感兴趣，包括比较有效性，患者和医生的偏好，决策过程以及患者报告结果的测量。在过去的4年里，在K24奖提供的保护时间内，我建立了一个全面的方法和内容为基础的计划，为有兴趣在风湿性疾病的成果研究中从事独立研究事业的学生，研究员，初级医生和博士教师提供指导和研究机会。该计划涵盖了休斯顿德克萨斯医疗中心的各种学术机构。拟议的继续计划是跨学科的，并在肌肉骨骼疾病领域扩大临床研究机会和指导的重点。特别感兴趣的是对风湿性疾病和各种合并症（如癌症）患者的研究。我在德克萨斯大学MD安德森癌症中心的流变学部门工作。该项目与贝勒医学院免疫学、过敏和风湿病学科相关。我们共享一个联合临床奖学金计划，此外，我还指导贝勒及其附属退伍军人事务医疗中心的教师和研究员。我还与德克萨斯大学健康科学中心休斯顿的其他学术流变学项目密切合作。拟议的计划是基于我目前的赠款和计划的继续项目所产生的这项研究，包括：（1）中心的教育和研究治疗，由美国卫生保健研究和质量局（AHRQ）资助;（2）iADAPT，ARRA项目检查的发展和实施病人的决策辅助有关的肌肉骨骼条件;（3）对乙酰氨基酚的使用和毒性，由AHRQ资助的R18赠款;和（4）癌症患者骨质疏松症的护理质量。此外，我正在继续我以前的工作，其中包括我的许多学员，在风湿性疾病的治疗依从性和全膝关节置换术的结果。这些项目由R 01赠款资助，我目前正在为这些研究进行竞争性更新。这些项目是拟议的指导和研究计划的基础。K24奖将为我提供受保护的时间，继续指导休斯顿风湿病学学术界的其他人，并帮助他们在风湿病患者导向的研究中建立自己的独立职业生涯。

DESCRIPTION (provided by applicant): The overall goal of this K24 renewal application is to continue to develop and implement a patient-oriented mentoring and research program in rheumatic diseases throughout the Texas Medical Center (Houston, TX). I am a rheumatologist with a PhD degree in epidemiology, and an interest in clinical epidemiology and outcomes research in musculoskeletal disorders, including comparative effectiveness, patient and physician preferences, decision-making processes, and measurement of patient reported outcomes. During the past 4 years, with the protected time offered by the K24 award, I have established a comprehensive methodological and content- based program providing mentorship and research opportunities to students, fellows, and junior physician and PhD faculty interested in pursuing independent research careers in outcomes research in rheumatic diseases. The program has encompassed various academic institutions in the Houston Texas Medical Center. The proposed continuing program is interdisciplinary, and focuses in expanding clinical research opportunities and mentoring in the field of musculoskeletal disease. Of particular interest is research in patients with rheumatic disease and various comorbidities such as cancer. I am based in the Section of Rheumatology at the University of Texas MD Anderson Cancer Center. This program is linked to the Section of Immunology, Allergy and Rheumatology at Baylor College of Medicine. We share a joint clinical fellowship program and, in addition, I also mentor Faculty and fellows at Baylor and its affiliated Veteran Affairs Medical Center. I also closely collaborate with the other academic rheumatology program in Houston, at the University of Texas Health Sciences Center. The proposed program is based on my current grants and the planned continuation projects arising from this research, including: (1) Center for Education and Research on Therapeutics, funded by the Agency for Healthcare Research and Quality (AHRQ); (2) iADAPT, an ARRA project examining the development and implementation of patient decision aids with respect to musculoskeletal conditions; (3) Utilization and toxicity of acetaminophen, a R18 grant funded by AHRQ; and (4) Quality of care for osteoporosis in patients with cancer. In addition, I am continuing my previous work, which has included many of my mentees, in treatment adherence in the rheumatic diseases, and outcomes of total knee replacement. These projects were funded by R01 grants and I am currently working on competitive renewals for these studies. These projects are the basis for the proposed mentoring and research program. The K24 award will provide me with protected time to continue to mentor others in the Houston rheumatology academic community and help them establish their independent careers in patient-oriented research in rheumatic diseases.