Outcomes Research in Rheumatic Diseases: A Mentoring Program

描述（由申请人提供）：本次K24续期申请的总体目标是在整个德克萨斯医疗中心（Houston， TX）继续开发和实施以患者为导向的风湿病指导和研究项目。我是一名风湿病学家，拥有流行病学博士学位，对肌肉骨骼疾病的临床流行病学和结果研究感兴趣，包括比较有效性、患者和医生的偏好、决策过程和患者报告结果的测量。在过去的4年里，在K24奖提供的保护时间里，我建立了一个全面的方法和内容为基础的项目，为学生、研究员、初级医生和博士教师提供指导和研究机会，这些学生、研究员和博士教师有兴趣在风湿病的成果研究中追求独立的研究事业。该项目涵盖了休斯顿德州医疗中心的多个学术机构。拟议的持续计划是跨学科的，重点是扩大临床研究机会和指导在肌肉骨骼疾病领域。特别令人感兴趣的是风湿病和各种合并症（如癌症）患者的研究。我在德克萨斯大学MD安德森癌症中心的风湿病科工作。该项目与贝勒医学院的免疫学、过敏和风湿病学部门有关。我们有一个联合临床奖学金项目，此外，我还指导贝勒大学及其附属退伍军人事务医疗中心的教职员工和研究员。我还与休斯顿德克萨斯大学健康科学中心的其他风湿病学术项目密切合作。拟议的项目是基于我目前的拨款和本研究产生的计划继续项目，包括：(1)由医疗保健研究和质量局（AHRQ）资助的治疗学教育和研究中心；(2) iADAPT， ARRA项目，研究肌肉骨骼疾病患者决策辅助工具的开发和实施；(3)对乙酰氨基酚的利用和毒性，AHRQ资助的R18项目；(4)癌症患者骨质疏松的护理质量。此外，我正在继续我以前的工作，其中包括我的许多学生，在风湿病的治疗依从性和全膝关节置换术的结果方面。这些项目是由R01拨款资助的，我目前正在为这些研究进行竞争性续期。这些项目是建议的指导和研究计划的基础。K24奖项将为我提供受保护的时间，继续指导休斯顿风湿病学界的其他人，并帮助他们在风湿病患者导向的研究中建立自己的独立职业生涯。

DESCRIPTION (provided by applicant): The overall goal of this K24 renewal application is to continue to develop and implement a patient-oriented mentoring and research program in rheumatic diseases throughout the Texas Medical Center (Houston, TX). I am a rheumatologist with a PhD degree in epidemiology, and an interest in clinical epidemiology and outcomes research in musculoskeletal disorders, including comparative effectiveness, patient and physician preferences, decision-making processes, and measurement of patient reported outcomes. During the past 4 years, with the protected time offered by the K24 award, I have established a comprehensive methodological and content- based program providing mentorship and research opportunities to students, fellows, and junior physician and PhD faculty interested in pursuing independent research careers in outcomes research in rheumatic diseases. The program has encompassed various academic institutions in the Houston Texas Medical Center. The proposed continuing program is interdisciplinary, and focuses in expanding clinical research opportunities and mentoring in the field of musculoskeletal disease. Of particular interest is research in patients with rheumatic disease and various comorbidities such as cancer. I am based in the Section of Rheumatology at the University of Texas MD Anderson Cancer Center. This program is linked to the Section of Immunology, Allergy and Rheumatology at Baylor College of Medicine. We share a joint clinical fellowship program and, in addition, I also mentor Faculty and fellows at Baylor and its affiliated Veteran Affairs Medical Center. I also closely collaborate with the other academic rheumatology program in Houston, at the University of Texas Health Sciences Center. The proposed program is based on my current grants and the planned continuation projects arising from this research, including: (1) Center for Education and Research on Therapeutics, funded by the Agency for Healthcare Research and Quality (AHRQ); (2) iADAPT, an ARRA project examining the development and implementation of patient decision aids with respect to musculoskeletal conditions; (3) Utilization and toxicity of acetaminophen, a R18 grant funded by AHRQ; and (4) Quality of care for osteoporosis in patients with cancer. In addition, I am continuing my previous work, which has included many of my mentees, in treatment adherence in the rheumatic diseases, and outcomes of total knee replacement. These projects were funded by R01 grants and I am currently working on competitive renewals for these studies. These projects are the basis for the proposed mentoring and research program. The K24 award will provide me with protected time to continue to mentor others in the Houston rheumatology academic community and help them establish their independent careers in patient-oriented research in rheumatic diseases.