Methods Training in Patient-Centered Cancer Outcomes Research

以患者为中心的癌症结果研究方法培训

• 批准号: 9292268
• 负责人: Maria E Suarez-Almazor
• 金额: $ 49.27万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9292268
• 关键词: Methods; Training; Patient; Centered; Cancer

DESCRIPTION (provided by applicant): One in three of us will develop cancer during our lifetime. This incidence will increase as the population ages. Advances in medical knowledge have lead to an exponential increase in healthcare options for the prevention, diagnosis and therapy of cancer. Choices among competing alternatives are often difficult because the available evidence may differ among options, and may not reflect values that are important to patients when making healthcare decisions. There is increasing recognition that patient preferences are instrumental in making appropriate decisions for care. Many studies are based on biomedical outcomes that are not easily understood by patients, and often, not well understood either by clinicians or policy-makers. Comparative effectiveness research (CER) aims to inform healthcare decisions by providing evidence on the benefits and harms of different alternatives. CER synthesizes and generates comparable evidence on the effectiveness of interventions so that decision-makers (patients, clinicians and policy-makers) can make informed choices. Patient-centered outcomes research (PCOR) ensures that the evidence gathered through CER is relevant to patients and provides information on outcomes that people care about: survival, symptoms, function and quality of life. This is especially important for patients with cancer since therapies can be effective for some outcomes (e.g. disease- free survival) but deleterious for others (e.g. quality of life affected by treatment toxicity). As CER/PCOR evolves there is increased need for training researchers in this area. For this proposal we have partnered with the American Society of Clinical Oncology (ASCO) to offer training and workforce development opportunities in the field of CER/PCOR in cancer care. The goal of this application is to provide a comprehensive training program for cancer researchers interested in CER/PCOR. We have identified four major interrelated methodology cores for training: (i) Knowledge synthesis and translation; (ii) Observational research and registries; (iii Pragmatic clinical trials and healthcare delivery evaluation; and (iv) Patient-centered outcomes research. Our program will provide different levels of training. Basic learning modules will be implemented through on-demand online lectures and interactive components (Q&A online sessions and methods blog). Advanced methods training will be offered in partnership with ASCO and will include Webinars and hands-on face-to-face educational workshops. Finally, on-site experiential learning for fellows will be provided with specialization in one of the core area identified above. This component will also include a personalized mentoring plan. Our training program will encompass the whole spectrum of cancer care including prevention, cancer treatment and healthcare delivery, supportive care, survivorship, and end-of-life care. The proposed program is unique in the field of cancer research, it will provide innovative peer-to-peer learning opportunities, and will enhance best research practices. The training proposed here will increase the nation's workforce of researchers conducting state-of-the-art CER/PCOR throughout the spectrum of cancer care.

描述（由申请人提供）：我们三分之一的人在一生中会患上癌症。随着人口老龄化，这种发病率将增加。医学知识的进步导致癌症预防、诊断和治疗的医疗保健选择呈指数级增长。在相互竞争的替代品中进行选择通常很困难，因为现有的证据可能在选项之间存在差异，并且可能无法反映患者在做出医疗保健决策时的重要价值。越来越多的人认识到，患者的偏好有助于做出适当的护理决定。许多研究都是基于患者不容易理解的生物医学结果，而且临床医生或政策制定者往往也不太理解。比较有效性研究（CER）旨在通过提供有关不同替代品的益处和危害的证据来为医疗保健决策提供信息。CER综合并生成有关干预措施有效性的可比证据，以便决策者（患者，临床医生和政策制定者）可以做出明智的选择。以患者为中心的结局研究（PCOR）确保通过CER收集的证据与患者相关，并提供人们关心的结局信息：生存，症状，功能和生活质量。这对于癌症患者尤其重要，因为治疗可能对某些结果有效（例如无病生存期），但对其他结果有害（例如受治疗毒性影响的生活质量）。随着CER/变革和组织振兴方案的发展，对这一领域的研究人员进行培训的必要性日益增加。对于这项提案，我们与美国临床肿瘤学会（ASCO）合作，在癌症护理的CER/PCOR领域提供培训和劳动力发展机会。该应用程序的目标是为对CER/PCOR感兴趣的癌症研究人员提供全面的培训计划。我们已经确定了四个主要的相互关联的培训方法核心：（i）知识综合和翻译;（ii）观察性研究和登记;（iii）实用的临床试验和医疗服务评估;（iv）以患者为中心的结果研究。我们将提供不同层次的培训。基本学习单元将通过按需在线讲座和互动部分（在线问答和方法博客）实施。先进的方法培训将与ASCO合作提供，并将包括网络研讨会和动手面对面的教育研讨会。最后，将为研究员提供上述核心领域之一的现场经验学习。这一部分还将包括一个个性化的辅导计划。我们的培训计划将涵盖癌症护理的整个范围，包括预防，癌症治疗和医疗保健提供，支持性护理，生存和临终关怀。该计划在癌症研究领域是独一无二的，它将提供创新的点对点学习机会，并将加强最佳研究实践。这里提出的培训将增加国家的研究人员队伍，在整个癌症护理领域进行最先进的CER/PCOR。