Post-Prandial Nutrient Partitioning in Humans

描述(由申请人提供)： 在美国和世界各地，肥胖是一个严重且日益严重的公共健康问题。研究人员需要具备一系列生理和行为方法的知识和经验，通过在人类受试者身上进行对照研究，将动物研究中的新信息转化为对人类的新见解。这个应用程序是以一种小的方式设计来满足这种需求的。申请者是一名职业生涯中期的调查员，在饮食脂肪代谢、胰岛素抵抗和体重调节领域的动物和人类研究方面都有经验，他要求再支持5年1.继续在过度和不足条件下对人体受试者进行生理学研究，以探索身体如何感知营养平衡，以及对正和/或负能量平衡的生物/行为反应如何与体重增加有关。2.利用他在以病人为导向的研究(POR)方面的经验，继续指导初级研究人员在脂类代谢、胰岛素抵抗、饥饿/饱腹感、运动、体重增加/减轻及相关领域的研究。3.促进主要在体外工作的现有基础研究人员与进行人体生理研究的初级研究人员之间的互动和实验合作。4.继续将一些行政时间用于促进初级调查员专业发展的活动，并为这些人提供机会考虑在警察部门工作。在之前的支持期间，申请者获得了新的RO1，该RO1支持对瘦和肥胖倾向者进行的前瞻性纵向队列研究，以了解对短期过度喂养的生理和行为反应是否预示着随后的体重增加。此外，在支持期间与他共事的11名博士后研究员中，有6人获得了K奖，2人获得了个人NRSA奖。他指导的两名初级调查人员获得了个人RO1奖，他为其提供技术支持的公司获得了SBIR。

DESCRIPTION (provided by applicant): Obesity is a serious and growing public health problem in this country and around the world. There is a continuing need for investigators with the knowledge of and experience with a range of physiological and behavioral methods to translate new information from studies in animals into new insights in humans through the performance of controlled studies in human subjects. This application is designed in a small way to address this need. The applicant is a mid-career investigator with experience in both animal and human studies in the areas of dietary fat metabolism, insulin resistance, and body weight regulation who is requesting 5 more years of support to 1. continue physiological studies in human subjects conducted in the over and underfed conditions to explore how the body senses nutrient balance and how biological/behavioral responses to positive and/or negative energy balance relate to weight gain. 2. To use his experience in patient oriented research (POR) to continue to mentor junior investigators in their studies of lipid metabolism, insulin resistance, hunger/satiety, exercise, weight gain/loss and related areas. 3. To facilitate interactions and experimental collaborations between established basic researchers working primarily in vitro with junior investigators performing physiological studies in human subjects. 4. To continue to devote some administrative time to activities that promote the professional development of junior investigators and provide the opportunity for these individuals to consider a career in POR. During the previous period of support the applicant was awarded a new RO1 that is supporting a prospective longitudinal cohort study of thin and obesity prone individuals to see if physiological and behavioral responses to short term overfeeding predict subsequent weight gain. In addition, 6 of the 11 post-doctoral fellows that he has worked with during the period of support have received K awards and 2 have received individual NRSA awards. Two junior investigators that he has mentored have received individual RO1 awards and the company that he provides technical support for received an SBIR.