POST-PRANDIAL NUTRIENT PARTITIONING IN HUMANS

描述（改编自应用程序） 此申请的目的是确保部分工资支持的资金 为指定的私家侦探来减轻他的一些临床责任 目前提供工资。这将使患者有更多的时间进行 本提案中概述的面向研究和指导博士后研究员 在科罗拉多健康大学人类营养中心（CHN） 科学中心（UCHSC）。私家侦探能够很好地发挥这些作用， 他在人类肥胖领域有临床研究的历史， 最近获得了人类营养研究的独立资助， 目前担任CHN研究培训副主任 在詹姆斯·希尔医生的指导下一般临床的存在 研究中心（GCRC），临床营养研究单位（CNRU），和 CHN使UCHSC成为一个令人兴奋的肥胖相关研究机构 吸引了一大批优秀的博士后研究员， 是一个需要/机会，一个中期的职业生涯MD，以帮助指导 即可.这个奖项将巩固候选人在这个角色在一个重要的时刻 为他和中国。拟议的研究审查了假设， 与倾向于体重增加的人相比，瘦的人更多 准确地感知和响应代谢和行为的积极能量 平衡据推测，与减少肥胖相比，瘦个体 将对一段时间的正能量平衡作出反应， 葡萄糖氧化（胰岛素抵抗）， 骨骼肌的膳食脂肪以及进食动力下降。的结果 这些燃料代谢的差异是，瘦个体将更多 有效地防御正脂肪平衡状态， 减少肥胖为了测试这些想法瘦和减少肥胖的个人将 研究了三天的过度喂养。1.将进行正常血糖钳夹 检查胰岛素敏感性，2.将进行膳食研究， 包括在测试餐中的标记的脂肪和碳水化合物的代谢命运，和3. 饥饿感、饱腹感和适口性将在研究期间和之后进行测量。 高热量喂养间接量热法，示踪氧化，肢体平衡，和 骨骼肌和脂肪组织的采样，建议给予更多的 这两组中与膳食相关的营养素代谢的完整视图。这些 研究将提供对体重反弹的生物学倾向的深入了解 并将为未来的研究奠定基础， 存在于肥胖和肥胖前期的营养代谢异常 个体

DESCRIPTION (adapted from the application) The purpose of this application is to secure funding for partial salary support for the named P.I. to relieve him from some of the clinical responsibilities that currently provide salary. This would allow more time to perform patient oriented research outlined in this proposal and mentoring post-doctoral fellows at the Center for Human Nutrition (CHN) at the University of Colorado Health Sciences Center (UCHSC). The P.I. is well positioned to serve these roles in that he has a history of clinical research in the area of human obesity, has recently received independent funding for human nutritional studies, and is currently serving as the Associate Director for Research Training at the CHN under the direction of Dr. James Hill. The presence of the General Clinical Research Center (GCRC), the Clinical Nutrition Research Unit (CNRU), and the CHN have made the UCHSC an exciting institution for obesity related research and has attracted a large number of excellent post-doctoral fellows but there is a need/opportunity for a mid [sic] career MD to help with the mentoring load. This award would solidify the candidate in this role at an important time for him and the CHN. The proposed research examines the hypothesis that as compared to individuals predisposed to weight gain, lean individuals more accurately sense and respond metabolically and behaviorally to positive energy balance. It is hypothesized that as compared to reduced obese, lean individuals will respond to a period of positive energy balance with a reduction [sic] the oxidation of glucose (insulin resistance), an increase in the oxidation of dietary fat by skeletal muscle, and a decreased drive to eat. The result of these differences in fuel metabolism are that lean individuals will more effectively defend against a state of positive fat balance as compared to reduced obese. To test these ideas lean and reduced obese individuals will be studied following 3-days of overfeeding. 1. Euglycemic clamps will be performed to examine insulin sensitivity, 2. meal studies will be performed examining the metabolic fate of labeled fat and carbohydrate included in a test meal, and 3. Hunger, satiety, and palatability will be measured during and following hypercaloric feeding. Indirect calorimetry, tracer oxidation, limb balance, and sampling of skeletal muscle and adipose tissue are proposed to give a more complete view of meal associated nutrient metabolism in these two groups. These studies will provide insight into the biology that predisposes to weight regain following weight reduction and will lay the groundwork for future studies of the abnormalities in nutrient metabolism that exist in obese and pre-obese individuals.