Developing Research Capacity for AIDS Malignancy in Kenya

发展肯尼亚艾滋病恶性肿瘤的研究能力

• 批准号: 8009569
• 负责人: Scot C Remick
• 金额: $ 53.83万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-09 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8009569
• 关键词: AIDS Malignancy Consortium; AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Africa South of the Sahara; African; African Burkitt' s lymphoma; Area; Clinical; Clinical Research; Clinical Trials; Collaborations; Developed Countries; Diagnostics Research; EBV-associated malignancy; Ensure; Epidemiologist; Epidemiology; Etiology; Future; Goals; Healthcare; Hematologist; Hospitals; Institution; International; Kenya; Leadership; Link; Lymphoma; Malignant Neoplasms; Medical; Medical Research; Ohio; Oncologist; Pathogenesis; Pathologist; Pathology; Pediatric Hospitals; Peer Review; Performance; Research; Research Activity; Research Institute; Research Personnel; Research Support; Research Training; Resources; Rosemary; Site; Therapeutic; Time; Tissues; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Viral; Virus; West Virginia; base; cancer specimen resource; diagnostic accuracy; experience; interest; multidisciplinary; neoplasm resource; programs; repository; tool; translational study; tumor; virology

DESCRIPTION (provided by applicant): An experienced international team of investigators building upon a decade-long collaboration are partnering to develop sustainable research capacity for studies on HIV-associated malignancies in Kenya. Our proposal provides an unprecedented opportunity for our partners - the University of Nairobi (UoN), Kenyatta National Hospital (KNH), and the Kenya Medical Research Institute (KEMRI) - 3 highly respected African institutions, enjoined on a dedicated AIDS malignancy NCl collaborative project for the first time. Our fundamental strategic approach is to let clinical studies drive our training program. We have developed 3 highly interactive and inter-dependent training aims focusing on: 1) diagnostic and research pathology; 2) tumor virology; and 3) clinical trials, which are vital to ensure a robust translational research program 3 years hence. Our international team is led by Drs. Scot Remick at West Virginia Univ., an AIDS oncologist and clinical trialist (U.S. PI); Leona W. Ayers at Ohio State Univ., HIV/AIDS pathologist; Rosemary Rochford at SUNY Upstate Medical Univ., EBV-associated malignancies and epidemiologist; Walter Mwanda at UoN and KNH, pediatric hematologist and clinical trialist (Kenya Senior Collaborator); and Geoffrey Mutuma at KEMRI, clinical pathologist. Our training program will link to the emerging African trials network and international research agenda led by the NCI-sponsored AIDS Malignancy Consortium (PI: R. Mitsuyasu, CAI21947) under Dr. Remick's leadership; build diagnostic and research pathology and tissue repository capacity to enable tissue-based correlative and translational studies through the NCI-sponsored AIDS Cancer Specimen Resource/Sub-Saharan African Lymphoma Consortium under Dr. Ayers leadership (CA066531); NIH-peer reviewed tumor virology research activities brought to this collaboration by Dr. Rochford's program (CA102667) focusing on strengthening capacity in virus research tools and epidemiological approaches to stimulate and broaden pathologists' and clinicians' interests in research questions and particularly collaborations in AIDS and other viral related tumors; and future NIH research opportunities as they evolve. The overall goal of our training program is to consolidate and strengthen existing capacity in Kenya, which remains a resource-challenged, developing area of the world; and to develop strategic and inclusive multidisciplinary teams that are efficient and productive partners with investigators from developed countries. From our collaboration, we expect to have a well-trained doctoral level and support research staff in place ready to explore questions of diagnostic accuracy, viral etiology, and therapeutic alternatives for AIDS malignancies and other viral tumors. We anticipate serving as a future site in sub-Saharan Africa for research and training in AIDS malignancies and other viral tumors building on our Kenyan-WVU/OSU/SUNY partnership. RELEVANCE: This proposal strengthens capacity for the performance of translational research focusing on AIDS- related malignancies in Kenya, a region of the world with the greatest burden of HIV/AIDS. The training plan builds on "trans-NIH" assets including the NCI-sponsored AIDS Malignancy Consortium, the Mid Region- AIDS & Cancer Resource, and Sub-Saharan Africa Lymphoma Consortium across 3 U.S. and 3 Kenyan academic healthcare institutions to better inform our understanding of pathogenesis, diagnostic accuracy, viral etiology, and therapeutic approach toward AIDS malignancies and other viral tumors.

描述（由申请人提供）：在长达十年的合作基础上，一个经验丰富的国际研究小组正在肯尼亚开展合作，为艾滋病毒相关恶性肿瘤的研究发展可持续的研究能力。我们的建议为我们的合作伙伴——内罗毕大学、肯雅塔国家医院和肯尼亚医学研究所——提供了前所未有的机会，这三个备受尊敬的非洲机构首次参与了一个专门的艾滋病恶性肿瘤NCl合作项目。我们的基本战略方针是让临床研究推动我们的培训计划。我们制定了三个高度互动和相互依存的培训目标，重点是：1)诊断和研究病理学；2)肿瘤病毒学；3)临床试验，这对确保3年后的强大转化研究项目至关重要。我们的国际团队由dr。西弗吉尼亚大学的艾滋病肿瘤学家和临床试验学家scott Remick（美国PI）；俄亥俄州立大学的HIV/AIDS病理学家Leona W. Ayers；纽约州立大学上州医科大学的Rosemary Rochford， ebv相关恶性肿瘤和流行病学家；联合国儿童医院和KNH的儿科血液学家和临床试验学家Walter Mwanda（肯尼亚高级合作者）；以及KEMRI的临床病理学家杰弗里·穆图玛。我们的培训项目将与Remick博士领导的由nci赞助的艾滋病恶性肿瘤联盟（PI: R. Mitsuyasu, CAI21947）领导的新兴非洲试验网络和国际研究议程联系起来；在Ayers博士的领导下，通过nci赞助的艾滋病癌症标本资源/撒哈拉以南非洲淋巴瘤联盟（CA066531），建立诊断和研究病理学和组织库能力，以实现基于组织的相关和转化研究；美国国立卫生研究院同行评审肿瘤病毒学研究活动由Rochford博士的项目（CA102667）带来，重点是加强病毒研究工具和流行病学方法的能力，以刺激和扩大病理学家和临床医生对研究问题的兴趣，特别是在艾滋病和其他病毒相关肿瘤方面的合作；以及未来NIH的研究机会。我们培训计划的总体目标是巩固和加强肯尼亚的现有能力，肯尼亚仍然是世界上一个资源匮乏的发展中地区；发展战略性和包容性的多学科团队，使其成为发达国家研究人员的高效和富有成效的合作伙伴。通过我们的合作，我们期望拥有训练有素的博士水平和支持研究人员，随时准备探索诊断准确性，病毒病因学以及艾滋病恶性肿瘤和其他病毒性肿瘤的治疗方案。我们期望在肯尼亚-威斯康星大学/俄勒冈州立大学/纽约州立大学的伙伴关系的基础上，成为撒哈拉以南非洲艾滋病恶性肿瘤和其他病毒性肿瘤研究和培训的未来站点。相关性：本提案加强了在世界上艾滋病毒/艾滋病负担最重的地区肯尼亚开展以艾滋病相关恶性肿瘤为重点的转化研究的能力。培训计划建立在“跨nih”资产的基础上，包括nci赞助的艾滋病恶性肿瘤联盟、中部地区艾滋病和癌症资源以及撒哈拉以南非洲淋巴瘤联盟，横跨3家美国和3家肯尼亚学术医疗机构，以更好地告知我们对艾滋病恶性肿瘤和其他病毒性肿瘤的发病机制、诊断准确性、病毒病因学和治疗方法的理解。