Developing Research Capacity for AIDS Malignancy in Kenya

发展肯尼亚艾滋病恶性肿瘤的研究能力

• 批准号: 8308611
• 负责人: Scot C Remick
• 金额: $ 53.09万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-09 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8308611
• 关键词: AIDS Malignancy Consortium; AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Africa South of the Sahara; African; African Burkitt' s lymphoma; Area; Clinical; Clinical Research; Clinical Trials; Collaborations; Correlative Study; Developed Countries; Diagnostics Research; EBV-associated malignancy; Ensure; Epidemiologist; Epidemiology; Etiology; Future; Goals; HIV; Healthcare; Hematologist; Hospitals; Institution; International; Kenya; Leadership; Link; Lymphoma; Malignant Neoplasms; Medical; Medical Research; Ohio; Oncologist; Pathogenesis; Pathologist; Pathology; Pediatric Hospitals; Peer Review; Performance; Research; Research Activity; Research Institute; Research Personnel; Research Support; Research Training; Resources; Rosemary; Site; Therapeutic; Time; Tissues; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Viral; Virus; West Virginia; base; cancer specimen resource; diagnostic accuracy; experience; interest; multidisciplinary; neoplasm resource; programs; repository; tool; translational study; tumor; virology

DESCRIPTION (provided by applicant): An experienced international team of investigators building upon a decade-long collaboration are partnering to develop sustainable research capacity for studies on HIV-associated malignancies in Kenya. Our proposal provides an unprecedented opportunity for our partners - the University of Nairobi (UoN), Kenyatta National Hospital (KNH), and the Kenya Medical Research Institute (KEMRI) - 3 highly respected African institutions, enjoined on a dedicated AIDS malignancy NCl collaborative project for the first time. Our fundamental strategic approach is to let clinical studies drive our training program. We have developed 3 highly interactive and inter-dependent training aims focusing on: 1) diagnostic and research pathology; 2) tumor virology; and 3) clinical trials, which are vital to ensure a robust translational research program 3 years hence. Our international team is led by Drs. Scot Remick at West Virginia Univ., an AIDS oncologist and clinical trialist (U.S. PI); Leona W. Ayers at Ohio State Univ., HIV/AIDS pathologist; Rosemary Rochford at SUNY Upstate Medical Univ., EBV-associated malignancies and epidemiologist; Walter Mwanda at UoN and KNH, pediatric hematologist and clinical trialist (Kenya Senior Collaborator); and Geoffrey Mutuma at KEMRI, clinical pathologist. Our training program will link to the emerging African trials network and international research agenda led by the NCI-sponsored AIDS Malignancy Consortium (PI: R. Mitsuyasu, CAI21947) under Dr. Remick's leadership; build diagnostic and research pathology and tissue repository capacity to enable tissue-based correlative and translational studies through the NCI-sponsored AIDS Cancer Specimen Resource/Sub-Saharan African Lymphoma Consortium under Dr. Ayers leadership (CA066531); NIH-peer reviewed tumor virology research activities brought to this collaboration by Dr. Rochford's program (CA102667) focusing on strengthening capacity in virus research tools and epidemiological approaches to stimulate and broaden pathologists' and clinicians' interests in research questions and particularly collaborations in AIDS and other viral related tumors; and future NIH research opportunities as they evolve. The overall goal of our training program is to consolidate and strengthen existing capacity in Kenya, which remains a resource-challenged, developing area of the world; and to develop strategic and inclusive multidisciplinary teams that are efficient and productive partners with investigators from developed countries. From our collaboration, we expect to have a well-trained doctoral level and support research staff in place ready to explore questions of diagnostic accuracy, viral etiology, and therapeutic alternatives for AIDS malignancies and other viral tumors. We anticipate serving as a future site in sub-Saharan Africa for research and training in AIDS malignancies and other viral tumors building on our Kenyan-WVU/OSU/SUNY partnership. RELEVANCE: This proposal strengthens capacity for the performance of translational research focusing on AIDS- related malignancies in Kenya, a region of the world with the greatest burden of HIV/AIDS. The training plan builds on "trans-NIH" assets including the NCI-sponsored AIDS Malignancy Consortium, the Mid Region- AIDS & Cancer Resource, and Sub-Saharan Africa Lymphoma Consortium across 3 U.S. and 3 Kenyan academic healthcare institutions to better inform our understanding of pathogenesis, diagnostic accuracy, viral etiology, and therapeutic approach toward AIDS malignancies and other viral tumors.

描述(由申请人提供)：一个经验丰富的国际调查小组在长达十年的合作基础上正在合作，为肯尼亚艾滋病毒相关恶性肿瘤的研究发展可持续的研究能力。我们的提议为我们的合作伙伴-内罗毕大学(UON)、肯雅塔国立医院(KNH)和肯尼亚医学研究所(KEMRI)-3个备受尊敬的非洲机构提供了一个前所未有的机会，首次受命于一个专门的艾滋病恶性肿瘤NCL合作项目。我们的基本战略方法是让临床研究推动我们的培训计划。我们制定了三个高度互动和相互依赖的培训目标，重点是：1)诊断和研究病理学；2)肿瘤病毒学；3)临床试验，这对确保3年后强大的转化研究计划至关重要。我们的国际团队由以下人员领导：西弗吉尼亚大学的Scot Remick博士，艾滋病肿瘤学家和临床试验专家(美国PI)；俄亥俄州立大学的Leona W.Ayers，艾滋病毒/艾滋病病理学家；纽约州立大学北部医科大学的Rosemary Rochford，EBV相关恶性肿瘤和流行病学家；UON和KNH的Walter Mwanda，儿科血液学家和临床试验专家(肯尼亚高级合作者)；以及KEMRI的临床病理学家Geoffrey Mutuma。我们的培训计划将与由NCI赞助的艾滋病恶性疾病联盟(PI：R.Mitsuyasu，CAI21947)领导的新兴非洲试验网络和国际研究议程相联系；在雷米克博士的领导下，建立诊断和研究病理学和组织仓库能力，以通过NCI赞助的艾滋病癌症标本资源/撒哈拉以南非洲淋巴瘤联盟(CA066531)，实现基于组织的相关和翻译研究；NIH同行评审了Rochford博士的计划(CA102667)为此次合作带来的肿瘤病毒学研究活动，重点是加强病毒研究工具和流行病学方法的能力，以激发和扩大病理学家和临床医生对研究问题的兴趣，特别是在艾滋病和其他病毒相关肿瘤方面的合作；以及随着研究的发展，NIH未来的研究机会。我们培训计划的总体目标是巩固和加强肯尼亚的现有能力，肯尼亚仍然是一个资源短缺的发展中地区；并发展具有战略意义和包容性的多学科团队，这些团队是来自发达国家的研究人员的高效和富有成效的合作伙伴。通过我们的合作，我们希望拥有训练有素的博士水平，并支持研究人员准备好探索艾滋病恶性肿瘤和其他病毒肿瘤的诊断准确性、病毒病原学和治疗方案等问题。我们期望在我们肯尼亚-西弗吉尼亚大学/俄亥俄州立大学/纽约州立大学伙伴关系的基础上，未来在撒哈拉以南非洲成为艾滋病、恶性肿瘤和其他病毒性肿瘤研究和培训的地点。相关性：这项提议加强了在肯尼亚开展以艾滋病相关恶性肿瘤为重点的转化性研究的能力，肯尼亚是世界上艾滋病毒/艾滋病负担最重的地区。培训计划建立在“跨NIH”资产的基础上，包括NCI赞助的艾滋病恶性肿瘤联盟、中部地区-艾滋病和癌症资源以及撒哈拉以南非洲淋巴瘤联盟，该联盟横跨3个美国和3个肯尼亚学术医疗机构，以更好地帮助我们了解艾滋病恶性肿瘤和其他病毒肿瘤的发病机制、诊断准确性、病毒病因学和治疗方法。