Developing Research Capacity for AIDS Malignancy in Kenya

发展肯尼亚艾滋病恶性肿瘤的研究能力

• 批准号: 8125006
• 负责人: Scot C Remick
• 金额: $ 53.7万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-09 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8125006
• 关键词: AIDS Malignancy Consortium; AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Africa South of the Sahara; African; African Burkitt' s lymphoma; Area; Clinical; Clinical Research; Clinical Trials; Collaborations; Correlative Study; Developed Countries; Diagnostics Research; EBV-associated malignancy; Ensure; Epidemiologist; Epidemiology; Etiology; Future; Goals; HIV; Healthcare; Hematologist; Hospitals; Institution; International; Kenya; Leadership; Link; Lymphoma; Malignant Neoplasms; Medical; Medical Research; Ohio; Oncologist; Pathogenesis; Pathologist; Pathology; Pediatric Hospitals; Peer Review; Performance; Research; Research Activity; Research Institute; Research Personnel; Research Support; Research Training; Resources; Rosemary; Site; Therapeutic; Time; Tissues; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Viral; Virus; West Virginia; base; cancer specimen resource; diagnostic accuracy; experience; interest; multidisciplinary; neoplasm resource; programs; repository; tool; translational study; tumor; virology

DESCRIPTION (provided by applicant): An experienced international team of investigators building upon a decade-long collaboration are partnering to develop sustainable research capacity for studies on HIV-associated malignancies in Kenya. Our proposal provides an unprecedented opportunity for our partners - the University of Nairobi (UoN), Kenyatta National Hospital (KNH), and the Kenya Medical Research Institute (KEMRI) - 3 highly respected African institutions, enjoined on a dedicated AIDS malignancy NCl collaborative project for the first time. Our fundamental strategic approach is to let clinical studies drive our training program. We have developed 3 highly interactive and inter-dependent training aims focusing on: 1) diagnostic and research pathology; 2) tumor virology; and 3) clinical trials, which are vital to ensure a robust translational research program 3 years hence. Our international team is led by Drs. Scot Remick at West Virginia Univ., an AIDS oncologist and clinical trialist (U.S. PI); Leona W. Ayers at Ohio State Univ., HIV/AIDS pathologist; Rosemary Rochford at SUNY Upstate Medical Univ., EBV-associated malignancies and epidemiologist; Walter Mwanda at UoN and KNH, pediatric hematologist and clinical trialist (Kenya Senior Collaborator); and Geoffrey Mutuma at KEMRI, clinical pathologist. Our training program will link to the emerging African trials network and international research agenda led by the NCI-sponsored AIDS Malignancy Consortium (PI: R. Mitsuyasu, CAI21947) under Dr. Remick's leadership; build diagnostic and research pathology and tissue repository capacity to enable tissue-based correlative and translational studies through the NCI-sponsored AIDS Cancer Specimen Resource/Sub-Saharan African Lymphoma Consortium under Dr. Ayers leadership (CA066531); NIH-peer reviewed tumor virology research activities brought to this collaboration by Dr. Rochford's program (CA102667) focusing on strengthening capacity in virus research tools and epidemiological approaches to stimulate and broaden pathologists' and clinicians' interests in research questions and particularly collaborations in AIDS and other viral related tumors; and future NIH research opportunities as they evolve. The overall goal of our training program is to consolidate and strengthen existing capacity in Kenya, which remains a resource-challenged, developing area of the world; and to develop strategic and inclusive multidisciplinary teams that are efficient and productive partners with investigators from developed countries. From our collaboration, we expect to have a well-trained doctoral level and support research staff in place ready to explore questions of diagnostic accuracy, viral etiology, and therapeutic alternatives for AIDS malignancies and other viral tumors. We anticipate serving as a future site in sub-Saharan Africa for research and training in AIDS malignancies and other viral tumors building on our Kenyan-WVU/OSU/SUNY partnership. RELEVANCE: This proposal strengthens capacity for the performance of translational research focusing on AIDS- related malignancies in Kenya, a region of the world with the greatest burden of HIV/AIDS. The training plan builds on "trans-NIH" assets including the NCI-sponsored AIDS Malignancy Consortium, the Mid Region- AIDS & Cancer Resource, and Sub-Saharan Africa Lymphoma Consortium across 3 U.S. and 3 Kenyan academic healthcare institutions to better inform our understanding of pathogenesis, diagnostic accuracy, viral etiology, and therapeutic approach toward AIDS malignancies and other viral tumors.

描述（由申请人提供）：一个经验丰富的国际研究人员团队建立在长达十年的合作伙伴关系，以发展可持续的研究能力，对艾滋病毒相关的恶性肿瘤在肯尼亚的研究。我们的建议为我们的合作伙伴提供了前所未有的机会-内罗毕大学（UoN），肯雅塔国立医院（KNH）和肯尼亚医学研究所（KEMRI）- 3个备受尊敬的非洲机构，首次被禁止参与专门的艾滋病恶性肿瘤NCI合作项目。我们的基本战略方法是让临床研究驱动我们的培训计划。我们已经制定了3个高度互动和相互依赖的培训目标，重点是：1）诊断和研究病理学; 2）肿瘤病毒学;和3）临床试验，这对于确保3年后强大的转化研究计划至关重要。我们的国际团队由西弗吉尼亚大学的Scot Remick博士领导，艾滋病肿瘤学家和临床试验者（美国PI）;艾尔斯在俄亥俄州州立大学，艾滋病毒/艾滋病病理学家;纽约州立大学上州医科大学的迷迭香罗奇福德，EBV相关恶性肿瘤和流行病学家; UoN和KNH的Walter Mwanda，儿科血液学家和临床试验家（肯尼亚高级合作者）; KEMRI的Geoffrey Mutuma，临床病理学家。我们的培训计划将与新兴的非洲试验网络和由NCI赞助的艾滋病研究联盟（PI：R。Mitsuyasu，CAI 21947）;建立诊断和研究病理学和组织储存库能力，以通过由Ayers博士领导的NCI赞助的艾滋病癌症标本资源/撒哈拉以南非洲淋巴瘤联盟进行基于组织的相关和转化研究（CA066531）;美国国立卫生研究院同行评审肿瘤病毒学研究活动带来的这一合作博士罗奇福德的计划（CA 102667），重点是加强病毒研究工具和流行病学方法的能力，以激发和扩大病理学家和临床医生对研究问题的兴趣，特别是在艾滋病和其他病毒相关肿瘤方面的合作;以及未来NIH研究的机会。我们培训计划的总体目标是巩固和加强肯尼亚的现有能力，肯尼亚仍然是世界上一个资源短缺的发展中地区;并发展战略性和包容性的多学科团队，与发达国家的调查人员建立高效和富有成效的合作伙伴关系。通过我们的合作，我们预计将拥有训练有素的博士水平和支持研究人员，随时准备探索艾滋病恶性肿瘤和其他病毒肿瘤的诊断准确性、病毒病因和治疗替代方案等问题。我们预计将作为一个未来的网站在撒哈拉以南非洲的研究和培训艾滋病恶性肿瘤和其他病毒性肿瘤的建设我们的肯尼亚西弗吉尼亚大学/俄勒冈州立大学/纽约州立大学的伙伴关系。相关性：该提案加强了肯尼亚开展转化研究的能力，重点是与艾滋病有关的恶性肿瘤，肯尼亚是世界上艾滋病毒/艾滋病负担最重的地区。培训计划建立在“trans-NIH”资产的基础上，包括NCI-sponsored艾滋病研究联盟，中部地区-艾滋病和癌症资源，以及3个美国和3个肯尼亚学术医疗机构的撒哈拉以南非洲淋巴瘤联盟，以更好地了解我们对艾滋病恶性肿瘤和其他病毒性肿瘤的发病机制，诊断准确性，病毒病因学和治疗方法的理解。