Cancer and tobacco control training and research across the lifespan in Kenya

肯尼亚整个生命周期的癌症和烟草控制培训和研究

• 批准号: 8652333
• 负责人: Scot C Remick
• 金额: $ 20.72万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-10 至 2016-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8652333
• 关键词: Acquired Immunodeficiency Syndrome; Address; Award; Cancer Burden; Cancer Control; Centers for Disease Control and Prevention (U.S.); Cerebrovascular Disorders; Child; Chronic; Clinical Trials; Collaborations; Communicable Diseases; Country; Development; E-learning; Educational process of instructing; Electronics; Evidence based intervention; Feeds; Foundations; Funding; Goals; Grant; Health; Health Policy; Health Sciences; Health Services Accessibility; Hospital Referrals; Hospitals; Indiana; International; Kenya; Laboratories; Lead; Link; Longevity; Malignant Neoplasms; Medical Research; Modeling; Morbidity - disease rate; Pathologist; Pathology; Population-Based Registry; Public Health; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Training; Site; Solid; Time; Tobacco Use Cessation; Tobacco use; Training; Training Programs; Translating; Tumor Pathology; Universities; West Virginia; Writing; cancer care; cancer diagnosis; college; community intervention; end of life; experience; hospice environment; human subject protection; member; mortality; multidisciplinary; next generation; programs; public policy on tobacco; responsible research conduct; symposium; tobacco control; tumor; virology

DESCRIPTION (provided by applicant): The burden of cancer and tobacco consumption are major causes of morbidity and mortality in Kenya, a country with limited research infrastructure and significant scarcity to address these ever increasing chronic, non- communicable disease (NCD) threats to public health. Building on a near 15-year long research collaboration in Nairobi; a 20-year long academic partnership Academic Model Providing Access to Healthcare in Eldoret; capitalizing on a current NCI D43 training grant devoted to AIDS malignancy that is building critical pathology, tumor virology and clinical trials capacity; other NCI and CDC-funded research projects; an international team of highly interactive and experienced investigators led by Drs. Scot Remick, West Virginia University (WVU) and his senior Kenyan collaborator Walter Mwanda, University of Nairobi (UoN); Dr. Geoffrey Mutuma at Kenya Medical Research Institute (KEMRI); Dr. Brigid Sirengo at Nairobi Hospice; Dr. Patrick Loehrer at Indiana University (IU) and his senior Kenyan collaborator Dr. Naftali Busakhala, Moi University (MU) are partnering to develop sustainable research capacity for cancer and tobacco control in Kenya across the lifespan. Our training program will link for the first time the 5 essential academic medical and research centers in Kenya: UoN College of Health Sciences and affiliated Kenyatta National Hospital (KNH) in Nairobi; KEMRI; and the MU College of Health Sciences and affiliated Moi Teaching and Referral Hospital (MTRH) in Eldoret. The overall goal of our D43 training program is to bridge existing research capacity in Kenya, enabling strategic and inclusive multidisciplinary teams that will provide a solid foundation for development and implementation of evidence-based interventions relevant to cancer and tobacco control that will translate into Kenyan public health policy. The essential objectives are to strengthen the infrastructure for cancer and tobacco control in Kenya such that by the end of the 5-year Fogarty award highly interactive teams of investigators and research personnel will: (1) register cancer and other NCD entities (e.g., cerebrovascular disease) in population-based registries to inform national health officials and research programs; (2) develop effective tobacco cessation and control strategies for community intervention(s) and further frame tobacco policy; (3) support pathology research projects for successful completion of the MMed(Pathology) degree program to develop the next generation of trained pathologists for cancer diagnosis and lead multidisciplinary tumor boards; and (4) build research capacity for end-of-life cancer care and generate effective evidence-based interventions especially for children with cancer. Common training themes include: (1) the bulk of the training will be on-site in Kenya, which allows us to provide direct training for more members of our health teams; (2) address both intellectual - "people" and technical - "laboratory" capacities; (3) provide a variety of short, medium and long-term, "south-to-south", and electronic/web-based training coursework taking advantage of a newly fit-up electronic conference room in the Department of Pathology at UoN; and (4) provide training for the responsible conduct of research, protections of human subjects, and scientific/grants writing that feeds into a pilot research awards mechanism.

描述（由申请人提供）：癌症和烟草消费的负担是肯尼亚发病和死亡的主要原因，该国的研究基础设施有限，而且严重缺乏应对这些日益增加的慢性非传染性疾病（NCD）对公共健康的威胁。在内罗毕进行了近 15 年的研究合作；为期 20 年的学术合作伙伴关系学术模式为埃尔多雷特提供医疗保健服务；利用当前专门用于艾滋病恶性肿瘤的 NCI D43 培训赠款，该赠款正在建设关键病理学、肿瘤病毒学和临床试验能力；其他 NCI 和 CDC 资助的研究项目；由博士领导的高度互动且经验丰富的研究人员组成的国际团队。西弗吉尼亚大学 (WVU) 的 Scot Remick 和他的肯尼亚高级合作者内罗毕大学 (UoN) 的 Walter Mwanda；肯尼亚医学研究所 (KEMRI) 的 Geoffrey Mutuma 博士；内罗毕临终关怀中心的 Brigid Sirengo 博士；印第安纳大学 (IU) 的 Patrick Loehrer 博士和他的肯尼亚高级合作者、莫伊大学 (MU) 的 Naftali Busakhala 博士正在合作开发肯尼亚在整个生命周期中癌症和烟草控制的可持续研究能力。我们的培训计划将首次将肯尼亚 5 个重要的学术医学和研究中心联系起来：内罗毕的 UoN 健康科学学院和附属肯雅塔国家医院 (KNH)； KEMRI；密西根大学健康科学学院以及位于埃尔多雷特的附属莫伊教学和转诊医院 (MTRH)。我们 D43 培训计划的总体目标是加强肯尼亚现有的研究能力，建立战略性和包容性的多学科团队，为制定和实施与癌症和烟草控制相关的循证干预措施奠定坚实的基础，并将其转化为肯尼亚公共卫生政策。基本目标是加强肯尼亚癌症和烟草控制的基础设施，以便在福格蒂奖五年期结束时，由调查人员和研究人员组成的高度互动的团队将：(1) 在人口登记处登记癌症和其他非传染性疾病实体（例如脑血管疾病），以通知国家卫生官员和研究项目； (2) 为社区干预制定有效的戒烟和控制策略，并进一步制定烟草政策； (3) 支持病理学研究项目，以成功完成医学硕士（病理学）学位课程，以培养下一代经过培训的癌症诊断病理学家并领导多学科肿瘤委员会； (4) 建设临终癌症护理的研究能力，并制定有效的循证干预措施，特别是针对癌症儿童。常见的培训主题包括：（1）大部分培训将在肯尼亚现场进行，这使我们能够为更多的卫生团队成员提供直接培训； (2) 解决智力——“人”和技术——“实验室”能力； (3) 利用北方大学病理系新装修的电子会议室，提供各种短、中、长期、“南南”、电子/网络培训课程； (4) 为负责任的研究行为、人类受试者保护以及纳入试点研究奖励机制的科学/拨款写作提供培训。