A Period Seroprevalence (SARS-CoV-2) Survey in MHCCN Cancer Healthcare Workers (HCWs) Providing Patient Care during the Height of the Outbreak: A Registry Study

对在疫情高峰期提供患者护理的 MHCCN 癌症医护人员 (HCW) 进行的期间血清阳性率 (SARS-CoV-2) 调查：登记研究

• 批准号: 10166146
• 负责人: Scot C Remick
• 金额: $ 12.89万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-13 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10166146
• 关键词: 2019-nCoV; Academic Medical Centers; Address; Adult Respiratory Distress Syndrome; Aircraft; Antibodies; Antibody Response; Award; Biosensor; Blood specimen; COVID-19; Cancer Patient; Caring; Centers for Disease Control and Prevention (U.S.); China; Clinical; Clinical Trials; Coronavirus; Data; Disease; Disease Outbreaks; Enrollment; Ensure; Environment; Epidemiology; Equipment; Etiology; Future; Health; Health Personnel; Health system; Height; Immunocompromised Host; Immunoglobulin G; Immunoglobulin M; Individual; Infection; Inpatients; Investigation; Laboratories; Life; Light; Location; Longevity; Maine; Malignant Neoplasms; Measures; Medical History; Medical Oncologist; Nurses; Occupational; Occupational Exposure; Oncology; Outcome; Outpatients; Participant; Patient Care; Patients; Perception; Persons; Pharmacists; Plasma; Pneumonia; Population; Prevalence; Procedures; Provider; Public Health; RNA; Radiation Oncologist; Radiation Therapist; Registries; Reverse Transcriptase Polymerase Chain Reaction; Risk; Route; Rural; Rural Community; Rural Health; SARS coronavirus; Sailor; Sampling; Seasons; Seminal; Serologic tests; Serological; Seroprevalences; Services; Ships; Social Workers; Source; South Korea; Surgical Oncologist; Surveys; System; Testing; Virus; base; cancer care; care providers; chemotherapy; cohort; community setting; comorbidity; coronavirus disease; emotional distress; experience; first responder; flu; follow-up; improved; insight; medical supply; molecular diagnostics; novel coronavirus; novel virus; older patient; pandemic disease; parent grant; pathogen; patient population; recruit; response; rural cancer care; scale up; seroconversion; seropositive; sound; surveillance study; transmission process; viral transmission

In December 2019, the emergence of an as yet uncharacterized pneumonia in Wuhan, China heralded the onset of the coronavirus pandemic caused by Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2). The etiology and disease profile, aka Coronavirus Disease-2019 (COVID-19), has been quickly elucidated; though there is considerable lack of understanding of viral transmission. Public health measures to mitigate and contain the outbreak are hampered by scarcity and scaling up testing. The virus is among the most contagious in our lifetimes and thought to be primarily transmitted by droplet infection. Viral transmission also occurs by airborne routes and during asymptomatic periods of infection, which complicates public health measures. This is further compounded by lack of Personal Protective Equipment (PPE) and different strategies for use. These realities place Healthcare Workers (HCWs) at risk providing care to known infected patients and Persons Under Investigation (PUIs) with high suspicion of COVID-19. We propose a hypothesis-driven period sero-prevalence study of SARS-CoV-2 in MaineHealth Cancer Care Network (MHCCN) cancer Healthcare Workers (HCWs) at a sizeable rural health system and academic medical center. Our study is predicated on the lack of sound sero-epidemiological data to define occupational exposure and risk of SARS-CoV-2 infection in our cancer providers. We anticipate brisk recruitment of our cancer HCWs (Aim 1) and roll-out of a sero-antibody (IgG/IgM) test (Aim 2) to determine exposure. Brief clinical and occupational surveys will be completed. This cohort is invaluable to sustain and provide information on the SARS-CoV-2-transmission dynamics that will guide continued response to this pandemic, especially with an anticipated second wave that will inform cancer care in the rural community setting. This project is submitted in response to NOT-CA-20-0421 and is closely integrated and tethered to MaineHealth Lifespan NCORP (1UG1 CA239771-01) the parent grant that was submitted and subsequently awarded under PA-18-591.

2019年12月，中国武汉出现了一种尚未确定特征的肺炎，预示着由严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2）引起的冠状病毒大流行的开始。病原学和疾病概况，即2019年冠状病毒病（COVID-19），已被迅速阐明;尽管对病毒传播的了解相当缺乏。缓解和遏制疫情的公共卫生措施因检测不足和扩大规模而受阻。该病毒是我们一生中最具传染性的病毒之一，被认为主要通过飞沫感染传播。病毒传播也可通过空气传播途径和在无症状感染期间发生，这使公共卫生措施复杂化。缺乏个人防护设备和不同的使用策略进一步加剧了这一问题。这些现实使医疗工作者（HCW）面临风险，为已知的感染患者和高度怀疑COVID-19的受调查人员（PUI）提供护理。我们提出了一个假设驱动的时期SARS-CoV-2的血清流行率研究在缅因州健康癌症护理网络（MHCCN）癌症医护人员（HCW）在一个相当大的农村卫生系统和学术医疗中心。我们的研究是基于缺乏可靠的血清流行病学数据来确定我们的癌症提供者的职业暴露和SARS-CoV-2感染风险。我们预计将迅速招募癌症医护人员（目标1），并推出血清抗体（IgG/IgM）检测（目标2），以确定暴露情况。将完成简短的临床和职业调查。该队列对于维持和提供SARS-CoV-2传播动态信息非常宝贵，这些信息将指导对这一大流行病的持续应对，特别是预期的第二波将为农村社区环境中的癌症护理提供信息。本项目是根据NOT-CA-20-0421提交的，并与MaineHealth Lifespan NCORP（1UG 1 CA 239771 -01）紧密结合，该项目是根据PA-18-591提交并随后授予的母基金。