A MultiDisciplinary Cancer Research Facility at Purdue University

描述(由申请人提供)：NCRR ARRA C06计划提供了在普渡大学建立专注于疾病研究的实验室设施的机会。拟议的“多学科癌症研究机构”(MCRF)将把普渡大学癌症研究中心(CCR)来自不同部门和学科的研究人员放在一起进行协作、跨学科研究，以建立产生创新的疾病动物模型、开发新疗法和活体动物成像的能力--这是普渡大学疾病研究人员尚未满足的关键需求。该设施将包括一个现代化的动物成像套件，其中将容纳9.4特斯拉40厘米口径磁共振成像仪、单光子发射计算机断层扫描/计算机断层扫描(SPECT/CT)和多模式(包括荧光和X射线)全动物成像系统；所有这些都将位于拟建的设施的隔膜中，该隔膜也将容纳成功的CCR转基因小鼠生产操作。MCRF是位于普渡大学多学科研究中心探索公园(DP)的宾德利生物科学中心(BBC)的拟议建筑面积约29,000平方英尺。MCRF设施研究将补充BBC在生物物理和生物分子分析、常规细胞成像和分离以及高通量筛选技术方面已建立的能力，并将从中受益。此外，MCRF将与伯克纳米技术中心连接，以获得纳米医学能力。MCRF的实验室将采用DP共享空间政策，并将按职能组织，以便同时为多个研究人员和项目提供服务。实验室计划用于癌细胞生物学、治疗和医疗器械开发、基于细胞的筛选、药物化学和下一代成像。拟议中的增建将巩固普渡大学在癌症研究、工程、化学和仪器以及兽医方面的优势，拥有一个专注于疾病研究的多学科生物医学研究设施。多学科方法扩大了癌症和其他疾病的研究进展，这些方法为寻求更好地了解疾病以及更好的诊断和治疗带来了效率和创新。MCRF将扩展普渡大学在生物医学多学科研究方面的卓越表现。

DESCRIPTION (provided by applicant): The NCRR ARRA C06 program provides an opportunity to build a disease research focused laboratory facility at Purdue University. The proposed 'Multidisciplinary Cancer Research Facility' (MCRF) will co-locate Purdue Center for Cancer Research (CCR) investigators from diverse departments and disciplines for collaborative, transdisciplinary research that will build capabilities for generation of innovative animal models of disease, development of new therapeutics, and in vivo animal imaging - a critical unmet need for disease researchers at Purdue. The facility will include a modern animal imaging suite that will accommodate a 9.4 Tesla 40cm bore Magnetic Resonance Imager, Single Photon Emmission Computer Tomography/ Computer Tomography (SPECT/CT), and multimodal (including fluorescence and x-ray) whole animal imaging system; all in the proposed facility vivarium with barrier function that will also house the successful CCR transgenic mouse production operation. The MCRF is a proposed ~29,000 gross square feet addition to the Bindley Bioscience Center (BBC) in Purdue's hub for multidisciplinary research, Discovery Park (DP). MCRF facility research will provide a complement to, and will benefit from, established BBC capabilities in biophysical and biomolecular analyses, conventional cell imaging and separation, and high throughput screening technologies. In addition, the MCRF will connect with the Birck Nanotechnology Center for nanomedicine capabilities. Laboratories in the MCRF will adopt the DP shared space policy and will be organized by function to serve multiple investigators and projects simultaneously. Laboratories are planned for cancer cell biology, thereapeutic and medical device development, cell-based screening, medicinal chemistry, and next generation imaging. The proposed building addition will build on strengths at Purdue University in cancer research, engineering, chemistry and instrumentation, and veterinary medicine, with a disease research-focused, multidisciplinary facility for biomedical research. Research progress in cancer and other diseases is augmented by multidisciplinary approaches that bring efficiency and innovation to the search for better understanding of disease, as well as better diagnostics and therapeutics. The MCRF will extend Purdue's excellence in biomedical multidisciplinary research.