Expansion of Animal Resources for Large Animals

描述(由申请者提供)：杜克大学致力于科学研究及其翻译，以改善人类健康，包括通过在研究中适当使用动物。杜克大学的研究人员目前或过去的研究需要大量使用美国农业部覆盖的物种，他们要为美国国立卫生研究院每年20,407,773美元的直接成本负责。预计到2016年，这些计划的力度将使大型动物物种的需求翻一番，而目前的需求已经超过了能力。为了扩大、现代化和集中美国农业部覆盖的物种的住房和程序空间，满足这些物种当前和预计的研究需求，并使空置空间能够回填，提议在杜克大学现有的中央间隔区基础上建造一座两层楼的建筑，总SF为19,215(GSF)(净SF为16,763，效率为87%)。增加的空间将包括一楼的非人类灵长类动物住所和程序空间(8,423 NSF)和二楼的大型动物住所和程序空间(8,340 NSF)。增加的设施将允许在这个单一的内整合美国农业部覆盖的物种，同时促进专门设备的共享和增强安全性。这是专门为美国农业部覆盖的物种建造的，它的设计将是灵活的，以随着未来几年研究需求的发展而最大限度地发挥其效用。该设计还利用现有的洗罐、支持和手术设施，最大限度地增加了对研究的影响。与现有的中央隔膜和外科展馆毗邻，新馆将无缝地纳入杜克大学实验动物资源部的兽医、动物护理和行政结构。这一新增项目的规划始于2007年，但由于经济原因于2008年暂停。杜克大学已经无法满足目前对非人类灵长类动物、农业动物和犬类的教员需求，而且这些物种的空间限制排除了招聘依赖这些模型的教员的可能性。此外，杜克大学的研究人员在神经生物学、运动障碍、外科手术、移植、心血管疾病、传染病和其他领域拥有有希望的发现和翻译进展，但由于中央住房限制和美国农业部涵盖的物种有限的程序空间，无法加快翻译或扩大他们的研究范围。此外，杜克大学的间隔室不能支持根据良好实验室规范(GLP)法规进行的研究，这限制了调查人员在向食品和药物管理局提交监管档案之前在内部进行安全和毒性研究的能力。当前使用的空间设计不佳，使得对这些物种的常规饲养、护理和监测效率低下，加剧了这些问题。拟议的项目将纠正这些现有的问题，这样做将加快发现和转换，为基础、转换和临床前研究提供最先进的空间，并创造短期和长期的就业机会。为了与杜克大学对可持续发展的承诺保持一致，该项目将满足LEED认证的要求。

DESCRIPTION (provided by applicant): Duke University is committed to scientific research and its translation to improve human health, including through appropriate use of animals in research. Duke researchers whose current or past investigations have required significant use of USDA-covered species are responsible for $20,407,773 in annual direct costs from the National Institutes of Health. Strength of these programs is projected to double the need for large animal species by 2016, and current demand already exceeds capacity. To expand, modernize and centralize housing and procedural space for USDA-covered species, to meet current and projected research needs with these species, and to enable backfill of vacated spaces, construction of a two-story addition of 19,215 gross sf (gsf) (16,763 net sf, 87% efficiency), to Duke's existing Central Vivarium is proposed. The addition will include non-human primate housing and procedure space on the first floor (8,423 nsf) and large animal housing and procedure space on the second floor (8,340 nsf).The addition will allow consolidation of USDA-covered species within this single vivarium, while facilitating sharing of specialized equipment and enhancing security. Purpose-built for USDA-covered species, the addition will be designed to be flexible to maximize its usefulness as research needs evolve in coming years. The design also maximizes the addition's impact on research by utilizing existing cagewashing, support and surgical facilities. Contiguous with the existing Central Vivarium and Surgical Pavilion, the addition will be incorporated seamlessly into the veterinary, animal care, and administrative structure of Duke's Division of Laboratory Animal Resources. Planning for this addition was started in 2007 and halted in 2008 due to the economy. Duke already cannot accommodate current faculty needs for non-human primates, agricultural animals, and canines, and space constraints for these species have precluded recruitment of faculty who rely on these models. Furthermore, Duke investigators with promising findings and translational advances in neurobiology, movement disorders, surgery, transplantation, cardiovascular disease, infectious disease, and other fields are unable to accelerate translation or expand the scope of their research due to central housing constraints and limited procedural space for USDA-covered species. In addition, Duke's vivaria cannot support studies conducted under Good Laboratory Practice (GLP) regulations, restricting investigators' ability to conduct safety and toxicity studies in-house prior to submitting regulatory dossiers to the Food and Drug Admin. These problems are exacerbated by suboptimal design of the currently used space that makes routine husbandry, care, and monitoring of these species inefficient. The proposed project will rectify these existing problems, and in doing so will accelerate discovery and translation, provide state-of-the-art space for basic, translational, and pre-clinical studies, and create near-term and long-term jobs. In keeping with Duke's commitment to sustainability, the addition will meet requirements for LEED certification.