Expansion of Animal Resources for Large Animals

扩大大型动物的动物资源

• 批准号: 7873426
• 负责人: NANCY CATHERINE ANDREWS
• 金额: $ 1491.66万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-04 至 2015-03-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7873426
• 关键词: Agriculture; Animal Housing; Animals; Arts; Canis familiaris; Cardiovascular Diseases; Caring; Certification; Commit; Communicable Diseases; Direct Costs; Equipment; Faculty; Floor; Food; Health; Housing; Human; Investigation; Laboratory Animals; Modeling; Monitor; Movement Disorders; Neurobiology; Occupations; Operative Surgical Procedures; Organ Transplantation; Pharmaceutical Preparations; Procedures; Regulation; Research; Research Personnel; Research Project Grants; Safety; Security; Structure; Toxic effect; Translations; United States National Institutes of Health; Universities; animal care; animal resource; design; flexibility; good laboratory practice; improved; meetings; nonhuman primate; preclinical study; programs

DESCRIPTION (provided by applicant): Duke University is committed to scientific research and its translation to improve human health, including through appropriate use of animals in research. Duke researchers whose current or past investigations have required significant use of USDA-covered species are responsible for $20,407,773 in annual direct costs from the National Institutes of Health. Strength of these programs is projected to double the need for large animal species by 2016, and current demand already exceeds capacity. To expand, modernize and centralize housing and procedural space for USDA-covered species, to meet current and projected research needs with these species, and to enable backfill of vacated spaces, construction of a two-story addition of 19,215 gross sf (gsf) (16,763 net sf, 87% efficiency), to Duke's existing Central Vivarium is proposed. The addition will include non-human primate housing and procedure space on the first floor (8,423 nsf) and large animal housing and procedure space on the second floor (8,340 nsf).The addition will allow consolidation of USDA-covered species within this single vivarium, while facilitating sharing of specialized equipment and enhancing security. Purpose-built for USDA-covered species, the addition will be designed to be flexible to maximize its usefulness as research needs evolve in coming years. The design also maximizes the addition's impact on research by utilizing existing cagewashing, support and surgical facilities. Contiguous with the existing Central Vivarium and Surgical Pavilion, the addition will be incorporated seamlessly into the veterinary, animal care, and administrative structure of Duke's Division of Laboratory Animal Resources. Planning for this addition was started in 2007 and halted in 2008 due to the economy. Duke already cannot accommodate current faculty needs for non-human primates, agricultural animals, and canines, and space constraints for these species have precluded recruitment of faculty who rely on these models. Furthermore, Duke investigators with promising findings and translational advances in neurobiology, movement disorders, surgery, transplantation, cardiovascular disease, infectious disease, and other fields are unable to accelerate translation or expand the scope of their research due to central housing constraints and limited procedural space for USDA-covered species. In addition, Duke's vivaria cannot support studies conducted under Good Laboratory Practice (GLP) regulations, restricting investigators' ability to conduct safety and toxicity studies in-house prior to submitting regulatory dossiers to the Food and Drug Admin. These problems are exacerbated by suboptimal design of the currently used space that makes routine husbandry, care, and monitoring of these species inefficient. The proposed project will rectify these existing problems, and in doing so will accelerate discovery and translation, provide state-of-the-art space for basic, translational, and pre-clinical studies, and create near-term and long-term jobs. In keeping with Duke's commitment to sustainability, the addition will meet requirements for LEED certification.

描述（由申请人提供）：杜克大学致力于科学研究及其翻译，以改善人类健康，包括通过适当使用动物在研究中。目前或过去的调查需要大量使用USDA覆盖的物种的研究人员负责美国国立卫生研究院的年度直接成本为20,407,773美元。预计到2016年，这些计划的强度将使对大型动物物种的需求增加一倍，并且当前需求已经超过容量。扩大，现代化和集中化了被USDA覆盖的物种的住房和程序空间，以满足这些物种的当前和预计的研究需求，并使空置空间进行回填，以建造两层楼的两层楼，增加了19,215个毛额SF（GSF）（GSF）（16,763净SF，87％，87％，87％，87％的效率），向Duke的Central Central Vivarium提出了建议。该补充将包括一楼的非人类灵长类动物住房和程序空间（8,423 NSF）以及二楼的大型动物住房和程序空间（8,340 NSF）。该添加将允许在该单一的Vivarium中巩固被USDA被覆盖的物种，同时促进专用设备和增强安全性的共享。该添加物的专用物种是针对美国农业部覆盖的物种的，它将旨在灵活地提高其有用性，因为研究需求在​​未来几年的发展。该设计还通过利用现有的笼子洗涤，支持和手术设施来最大程度地提高增加对研究的影响。与现有的中央小肠和外科馆的连续，该添加剂将无缝地纳入杜克大学实验室动物资源部的兽医，动物护理和行政结构。此增加的计划始于2007年，由于经济而于2008年停止。杜克大学已经无法满足当前对非人类灵长类动物，农业动物和犬科动物的需求，这些物种的空间限制排除了依靠这些模型的教师的招募。此外，在神经生物学，运动障碍，手术，移植，心血管疾病，传染病和其他领域的神经生物学，运动障碍，手术，移植，心血管疾病，传染病和其他领域的转化进展的研究人员无法加速翻译或由于中心住房限制和有限的USDA培养物种的范围。此外，杜克大学的维瓦里亚（Vivaria）不能支持根据良好的实验室实践（GLP）法规进行的研究，从而限制了研究人员在向食品和药物管理员提交监管档案之前内部进行安全和毒性研究的能力。这些问题通过当前使用的空间的次优设计加剧，该空间常规饲养，关怀和监测这些物种效率低下。拟议的项目将纠正这些现有的问题，这样做将加速发现和翻译，为基础，转化和临床前研究提供最新的空间，并创造近期和长期工作。为了符合杜克（Duke）对可持续性的承诺，该增加将满足LEED认证的要求。