Vivarium Core

生态箱核心

• 批准号: 10425003
• 负责人: MELISSA A HARRINGTON
• 金额: $ 28.13万
• 依托单位: DELAWARE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10425003
• 关键词: Agriculture; Animal Experimentation; Animal Model; Animal Technicians; Animal Welfare; Animals; Award; Behavior; Biology; Brain; Caring; Cattle; Cells; Centers of Research Excellence; Characteristics; Charge; Cognition; Data; Delaware; Detection; Disease; Domestic Fowls; Electrophysiology (science); Ensure; Environment; Environmental Monitoring; Faculty; Faculty Recruitment; Feeling; Floods; Food; Foundations; Funding; Future; Future Teacher; Goat; Grant; Health; Health care facility; Home; Housing; Human; Human Resources; Infrastructure; Injury; Laboratory Animals; Lateral; Livestock; Melissa; Memory; Monitor; Motor Activity; Movement; Natural Resources; Nervous System Physiology; Neurosciences; Neurosciences Research; Phase; Positioning Attribute; Productivity; Psychology; Quality of Care; Quarantine; Research; Research Personnel; Research Project Grants; Research Subjects; Research Support; Resources; Rodent; Running; Science; Sheep; Supporting Cell; System; The Sun; Thinking; Time; Universities; Veterinarians; Water; animal care; animal facility; base; cost; data streams; digital; drinking; faculty research; faculty support; feeding; food surveillance; improved; insight; laboratory facility; member; mouse model; operation; programs; public health relevance; real time monitoring; recruit; sensor; tissue slice preparation; translational potential

Vivarium Core Summary The objective of this core is to support the operations of the Vivarium facility at Delaware State University and ensure that it provides both efficient operations to support the research of COBRE investigators at DSU and high quality care for our rodent research subjects. The research of several faculty members supported by the Phase I and Phase II COBRE awards depends on the operation of the vivarium for husbandry of mouse models for their research. Our COBRE Vivarium core will provide support and staff to maintain operations of our new rodent housing facility which was renovated with support from our Phase I COBRE grant, and which became fully operational in early 2017. COBRE support for the Vivarium Core at DSU will maintain the animal care staff including animal care technician, a facility manager and partial support for a veterinarian, so that the facility can provide outstanding animal care for COBRE-affiliated researchers to increase their research productivity. As the level of funding for faculty research grows eventually the facility can be sustained by charges to faculty research grants. We also propose to purchase and install the Tecniplast DVC® (Digital Ventilated Caging) complete system in the Vivarium. The complete system allows for 24/7 monitoring of food and water levels, as embedded sensors into the lateral runners detect the presence of food and water bottles cage by cage. The system evaluates bedding conditions and identifies when cages need to be changed reducing running costs, avoiding unnecessary animal handling, and providing 24/7 detection of unexpected water floods due to mishaps with water bottles. The round- the-clock animal activity detection allows for continuous animal welfare information, and since vital animal parameters (drinking, feeding, anomalies in locomotor activity) can be detected remotely, it will reduce the personnel entering the animal facilities. Real-time monitoring the environmental parameters and cage characteristics will also add precision to the timing of cage changes and other care-taking activities, reducing the need for staff time. With automated 24/7 tracking of the status of the cage environment and animal activity, the DVC system significantly improves animal welfare and facility efficiency and productivity, while providing researchers with a unique data stream that can improve the translational potential of their animal models. Continuation of the COBRE- supported Vivarium core will significantly advance the research program of COBRE investigators and help DSU recruit outstanding candidates for future faculty openings.

动物园核心 总结 该核心的目的是支持动物园设施的运行 在特拉华州州立大学，并确保它既提供有效的运作， 支持DSU的COBRE研究人员的研究，并为我们的 啮齿动物研究对象几位教员的研究得到了 第一阶段和第二阶段COBRE奖励取决于饲养小鼠模型的动物园的运作， 他们的研究。我们的COBRE Vivarium核心将提供支持和工作人员，以维持我们的新啮齿动物的运作 在我们第一阶段COBRE赠款的支持下进行了翻新的住房设施， 2017年初开始运营。DSU动物饲养中心的COBRE支持将维持动物护理人员 包括动物护理技术员、设施经理和兽医的部分支持，以便设施可以 为COBRE-affiliated研究人员提供出色的动物护理，以提高他们的研究效率。为 教师研究的资金水平最终会增长，该设施可以通过向教师研究收费来维持 赠款。 我们还建议购买和安装Tecniplast DVC®（数字通风笼舍）完整系统 在动物园。作为嵌入式传感器，完整的系统可实现全天候监测食物和水位 进入横向滑道，逐笼检测食物和水瓶的存在。系统评估寝具 条件和识别何时需要更换笼子，降低运行成本，避免不必要的动物 处理，并提供24/7检测意外的水洪水，由于事故与水瓶。子弹- 时钟动物活动检测允许连续的动物福利信息， 参数（饮水，进食，运动活动异常）可以远程检测，这将减少 进入动物设施的人员。实时监测环境参数和网箱特性 还将增加笼子更换和其他护理活动的时间精确性，减少对工作人员的需求， 时间 通过全天候自动跟踪笼舍环境和动物活动状态， 显著提高动物福利和设施效率和生产力，同时为研究人员提供 独特的数据流，可以提高他们的动物模型的翻译潜力。COBRE的延续- 支持的Vivarium核心将大大推进COBRE研究人员的研究计划，并帮助DSU 为未来的教职员招聘优秀的候选人。