Vivarium Core

生态箱核心

• 批准号: 10425003
• 负责人: MELISSA A HARRINGTON
• 金额: $ 28.13万
• 依托单位: DELAWARE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10425003
• 关键词: Agriculture; Animal Experimentation; Animal Model; Animal Technicians; Animal Welfare; Animals; Award; Behavior; Biology; Brain; Caring; Cattle; Cells; Centers of Research Excellence; Characteristics; Charge; Cognition; Data; Delaware; Detection; Disease; Domestic Fowls; Electrophysiology (science); Ensure; Environment; Environmental Monitoring; Faculty; Faculty Recruitment; Feeling; Floods; Food; Foundations; Funding; Future; Future Teacher; Goat; Grant; Health; Health care facility; Home; Housing; Human; Human Resources; Infrastructure; Injury; Laboratory Animals; Lateral; Livestock; Melissa; Memory; Monitor; Motor Activity; Movement; Natural Resources; Nervous System Physiology; Neurosciences; Neurosciences Research; Phase; Positioning Attribute; Productivity; Psychology; Quality of Care; Quarantine; Research; Research Personnel; Research Project Grants; Research Subjects; Research Support; Resources; Rodent; Running; Science; Sheep; Supporting Cell; System; The Sun; Thinking; Time; Universities; Veterinarians; Water; animal care; animal facility; base; cost; data streams; digital; drinking; faculty research; faculty support; feeding; food surveillance; improved; insight; laboratory facility; member; mouse model; operation; programs; public health relevance; real time monitoring; recruit; sensor; tissue slice preparation; translational potential

Vivarium Core Summary The objective of this core is to support the operations of the Vivarium facility at Delaware State University and ensure that it provides both efficient operations to support the research of COBRE investigators at DSU and high quality care for our rodent research subjects. The research of several faculty members supported by the Phase I and Phase II COBRE awards depends on the operation of the vivarium for husbandry of mouse models for their research. Our COBRE Vivarium core will provide support and staff to maintain operations of our new rodent housing facility which was renovated with support from our Phase I COBRE grant, and which became fully operational in early 2017. COBRE support for the Vivarium Core at DSU will maintain the animal care staff including animal care technician, a facility manager and partial support for a veterinarian, so that the facility can provide outstanding animal care for COBRE-affiliated researchers to increase their research productivity. As the level of funding for faculty research grows eventually the facility can be sustained by charges to faculty research grants. We also propose to purchase and install the Tecniplast DVC® (Digital Ventilated Caging) complete system in the Vivarium. The complete system allows for 24/7 monitoring of food and water levels, as embedded sensors into the lateral runners detect the presence of food and water bottles cage by cage. The system evaluates bedding conditions and identifies when cages need to be changed reducing running costs, avoiding unnecessary animal handling, and providing 24/7 detection of unexpected water floods due to mishaps with water bottles. The round- the-clock animal activity detection allows for continuous animal welfare information, and since vital animal parameters (drinking, feeding, anomalies in locomotor activity) can be detected remotely, it will reduce the personnel entering the animal facilities. Real-time monitoring the environmental parameters and cage characteristics will also add precision to the timing of cage changes and other care-taking activities, reducing the need for staff time. With automated 24/7 tracking of the status of the cage environment and animal activity, the DVC system significantly improves animal welfare and facility efficiency and productivity, while providing researchers with a unique data stream that can improve the translational potential of their animal models. Continuation of the COBRE- supported Vivarium core will significantly advance the research program of COBRE investigators and help DSU recruit outstanding candidates for future faculty openings.

生态箱核心 概括 该核心的目标是支持 Vivarium 设施的运营 特拉华州立大学并确保其提供高效的运营 支持 DSU 的 COBRE 研究人员的研究以及为我们提供高质量的护理 啮齿动物研究课题。多位教职员工的研究得到了 第一阶段和第二阶段 COBRE 奖项取决于饲养小鼠模型的动物园的运营情况 他们的研究。我们的 COBRE Vivarium 核心将提供支持和员工来维持我们新啮齿动物的运营 在我们第一期 COBRE 赠款的支持下对住房设施进行了翻修，并全面建成 于 2017 年初投入运营。COBRE 对 DSU 的 Vivarium Core 的支持将维持动物护理人员的工作 包括动物护理技术员、设施经理和兽医的部分支持，以便设施能够 为 COBRE 附属研究人员提供出色的动物护理，以提高他们的研究生产力。作为 教师研究的资助水平最终会增加 该设施可以通过向教师研究收费来维持 补助金。 我们还建议购买并安装 Tecniplast DVC®（数字通风笼）完整系统 在动物园里。完整的系统可以通过嵌入式传感器对食物和水位进行 24/7 监控 进入横向跑步者逐个笼子检测食物和水瓶的存在。系统评估床上用品 条件并确定何时需要更换笼子，降低运行成本，避免不必要的动物 处理，并提供 24/7 检测由于水瓶事故导致的意外洪水。回合—— 全天候动物活动检测可提供连续的动物福利信息，并且由于重要的动物 可以远程检测参数（饮水、进食、运动活动异常），这将减少 人员进入动物设施。实时监测环境参数和笼具特性 还将提高笼子更换和其他护理活动的时间精度，减少对工作人员的需求 时间。 DVC 系统可 24/7 自动跟踪笼内环境和动物活动的状态 显着提高动物福利和设施效率和生产力，同时为研究人员提供 独特的数据流可以提高动物模型的转化潜力。 COBRE 的延续- 支持的 Vivarium 核心将显着推进 COBRE 研究人员的研究计划并帮助 DSU 为未来的教师空缺招募优秀的候选人。