Conference on Central Nervous System Inflammation

中枢神经系统炎症会议

• 批准号: 6887144
• 负责人: Scott R BARNUM
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6887144
• 关键词: central nervous system disorders; inflammation; meeting /conference /symposium; neuroimmunomodulation; travel

DESCRIPTION (provided by applicant): Knowledge of the immunologic and inflammatory mechanisms contributing to acute and chronic central nervous system (CNS) diseases has increased dramatically in recent years. Inflammatory mediators and cellular processes once thought to be restricted to peripheral immune responses are now known to be central to the pathogenesis of many important CNS diseases, such as multiple sclerosis, Alzheimer's disease, stroke, HIV-dementia and others. Immune cell recruitment and regulation in the brain is molded by the CNS environment, in which cells such as microglia and astrocytes, elaborate a variety of potent regulatory mediators. The mediators include an expanding array of cytokines, chemokines, proteases, as well as, complement proteins and reactive oxygen species. Determining the role of these mediators in CNS disease has been advanced considerably by the development of transgenic and knock-out animal models. These animal models have, in many cases, provided unexpected results, thus broadening our understanding of inflammatory mechanisms in the CNS. This multi-disciplinary meeting will address recent advances in basic mechanisms, model approaches and novel therapies in immunologic and inflammatory diseases of the CNS through four specific aims: 1) Examination of how molecular and cellular effectors jointly contribute to CNS infiltration and inflammation, 2) Exploration of the complex relationship of inflammation and neurodegeneration - is inflammation always detrimental in the CNS?, 3) Comparing and contrasting the mechanisms of pathogen- versus host-induced inflammation and, 4) Examination of the controversy and risk of immunomodulation in chronic inflammatory diseases. The meeting program is composed of a diverse group of investigators (over 45% are women, ethnic minorities or young investigators) and less than 40% of the program speakers receive NIH funding.

描述（由申请人提供）：近年来，对导致急性和慢性中枢神经系统（CNS）疾病的免疫学和炎症机制的认识显著增加。 曾经被认为局限于外周免疫应答的炎性介质和细胞过程现在已知是许多重要CNS疾病（例如多发性硬化症、阿尔茨海默病、中风、HIV-痴呆等）的发病机制的中心。 脑中免疫细胞的募集和调节由CNS环境塑造，其中细胞如小胶质细胞和星形胶质细胞精心制作各种有效的调节介质。 介质包括细胞因子、趋化因子、蛋白酶以及补体蛋白和活性氧物质的扩展阵列。 通过转基因和基因敲除动物模型的发展，确定这些介质在中枢神经系统疾病中的作用已经有了相当大的进展。 在许多情况下，这些动物模型提供了意想不到的结果，从而拓宽了我们对CNS炎症机制的理解。 本次多学科会议将通过四个具体目标讨论CNS免疫和炎症疾病的基本机制，模型方法和新疗法的最新进展：1）检查分子和细胞效应器如何共同促进CNS浸润和炎症，2）探索炎症和神经变性的复杂关系-炎症总是对CNS有害吗？3)比较和对比病原体与宿主诱导的炎症机制，4）检查慢性炎症性疾病中免疫调节的争议和风险。 会议计划由不同的研究人员组成（超过45%是女性，少数民族或年轻的研究人员），不到40%的计划发言人接受NIH的资助。