Tissue Engineering Evaluation Criteria for Musculoskeletal Tissue Repair

肌肉骨骼组织修复的组织工程评价标准

• 批准号: 7225830
• 负责人: DAVID L BUTLER
• 金额: $ 1.8万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7225830
• 关键词: meeting /conference /symposium; musculoskeletal system; regeneration; tissue engineering; travel

DESCRIPTION (provided by applicant): In the last two decades, tissue engineering in academia and industry has become an exciting, multidisciplinary field offering the potential to repair or regenerate injured and diseased musculoskeletal and craniofacial tissues with living tissues. With this activity has come the need to allocate resources and choose among competing approaches. This challenge raises questions about criteria used to assess differing approaches. Which approaches are worth funding and what criteria should be used to monitor their success? Which parameters should be measured and what values should these parameters have? We propose to conduct a 2 1/2 day conference that will bring together bioengineers, surgeons, biologists, material scientists, and experts in commercial development to: 1) carefully reexamine general and tissue-specific goals for tissue engineering; 2) identify and prioritize criteria and threshold values for the design and evaluation of these tissue engineered repairs; and 3) identify needs in pre-clinical research to more rapidly achieve our goals. The entire group will meet at the beginning of each day to agree on the process for setting goals, criteria, and threshold values, and then at the end of the day to share results so as to identify common features of these parameters across tissue types. Participants will also be assigned to one of six tissue-specific teams (ligament, tendon, bone, articular cartilage, meniscus/TMJ and intervertebral disc) to include at least one bioengineer, surgeon, biologist, and material scientist. Each team will discuss overall goals and clinical needs, evaluative parameters and criteria for evaluating a specific tissue repair, establish where we are relative to these goals and possible threshold values of acceptability, and examine issues of efficacy, surgical handling and attachment, cost to manufacture, and projected times to preclinical and clinical trials. By continually questioning our progress along the way, we should be able to better assess promising tissue engineering approaches, assist funding agencies to most effectively spend their available research dollars in tissue engineering, and speed the development of useful products to clinical use.

描述（由申请人提供）：在过去的二十年中，学术界和工业的组织工程已成为一个令人兴奋的多学科领域，具有维修或再生和患病的肌肉骨骼和颅面组织的潜力。随着这项活动，需要分配资源并在竞争方法中进行选择。这项挑战提出了有关用于评估不同方法的标准的问题。哪些方法值得资金，应使用哪些标准来监控其成功？应该测量哪些参数，这些参数应该具有哪些值？我们建议进行2 1/2天的会议，将生物工程师，外科医生，生物学家，物质科学家和商业开发专家汇总为：1）仔细重新检查组织工程的一般和组织特定目标； 2）确定并优先考虑这些组织工程维修的设计和评估的标准和阈值； 3）确定临床前研究中的需求，以更快地实现我们的目标。整个小组将在每天开始开会，同意设定目标，标准和阈值值的过程，然后在一天结束时共享结果，以确定跨组织类型的这些参数的共同特征。参与者还将分配给六个组织特异性团队之一（韧带，肌腱，骨骼，关节软骨，弯月面/TMJ和椎间盘盘），其中包括至少一名生物工程师，外科医生，生物学家和材料科学家。每个团队将讨论评估特定组织修复的总体目标和临床需求，评估参数和标准，确定我们相对于这些目标以及可能的可接受性阈值值，并检查疗效，外科手术处理和依恋，制造成本以及对临床前和临床试验的预测时间。通过不断质疑我们的进步，我们应该能够更好地评估有希望的组织工程方法，协助资助机构最有效地将其可用的研究资金用于组织工程，并加快开发有用的产品以临床使用。