Tissue Engineering Evaluation Criteria for Musculoskeletal Tissue Repair

肌肉骨骼组织修复的组织工程评价标准

• 批准号: 7323582
• 负责人: DAVID L BUTLER
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7323582
• 关键词: Academia; Biomedical Engineering; Clinical; Clinical Trials; Development; Evaluation; Funding; Funding Agency; Goals; Histocompatibility Testing; Industry; Intervertebral disc structure; Life; Ligaments; Measures; Meniscus structure of joint; Monitor; Musculoskeletal; Natural regeneration; Operative Surgical Procedures; Participant; Process; Relative (related person); Research; Resources; Scientist; Speed; Surgeon; Tendon structure; Time; Tissue Engineering; Tissues; Wound Healing; abstracting; articular cartilage; bone; cost; craniofacial; day; design; injured; multidisciplinary; pre-clinical; pre-clinical research; repaired; success; symposium

Abstract In the last two decades, tissue engineering in academia and industry has become an exciting, multidisciplinary field offering the potential to repair or regenerate injured and diseased musculoskeletal and craniofacial tissues with living tissues. With this activity has come the need to allocate resources and choose among competing approaches. This challenge raises questions about criteria used to assess differing approaches. Which approaches are worth funding and what criteria should be used to monitor their success? Which parameters should be measured and what values should these parameters have? We propose to conduct a 2 ¿ day conference that will bring together bioengineers, surgeons, biologists, material scientists, and experts in commercial development to: 1) carefully re- examine general and tissue-specific goals for tissue engineering; 2) identify and prioritize criteria and threshold values for the design and evaluation of these tissue engineered repairs; and 3) identify needs in pre-clinical research to more rapidly achieve our goals. The entire group will meet at the beginning of each day to agree on the process for setting goals, criteria, and threshold values, and then at the end of the day to share results so as to identify common features of these parameters across tissue types. Participants will also be assigned to one of six tissue-specific teams (ligament, tendon, bone, articular cartilage, meniscus/TMJ and intervertebral disc) to include at least one bioengineer, surgeon, biologist, and material scientist. Each team will discuss overall goals and clinical needs, evaluative parameters and criteria for evaluating a specific tissue repair, establish where we are relative to these goals and possible threshold values of acceptability, and examine issues of efficacy, surgical handling and attachment, cost to manufacture, and projected times to preclinical and clinical trials. By continually questioning our progress along the way, we should be able to better assess promising tissue engineering approaches, assist funding agencies to most effectively spend their available research dollars in tissue engineering, and speed the development of useful products to clinical use.

抽象的 在过去的二十年中，学术界和工业的组织工程变得令人兴奋， 多学科领域，可维修或再生受伤和解散的肌肉骨骼 和带有活组织的颅面组织。随着这项活动，需要分配资源 并在竞争方法中选择。这个挑战提出了有关曾经的标准的问题 评估不同的方法。哪种方法值得资金，应使用哪些标准 监控他们的成功？应该测量哪些参数以及应该哪些值 参数有？我们建议进行2月的会议，将生物工程融合在一起， 外科医生，生物学家，物质科学家和商业开发专家至：1）仔细重新重新 检查组织工程的一般和组织特异性目标； 2）确定并确定标准和优先级 这些组织工程维修的设计和评估的阈值值； 3）确定需求 在临床前研究中，更快地实现了我们的目标。整个小组将在开始时见面 每天都同意设定目标，标准和阈值值的过程，然后在 共享结果的一天，以确定这些参数在组织类型之间的共同特征。 参与者还将分配给六个组织特异性团队之一（韧带，肌腱，骨骼，关节 软骨，半月板/TMJ和椎间盘）至少包括一名生物工程师，外科医生，生物学家， 和物质科学家。每个团队将讨论总体目标和临床需求，评估参数和 评估特定组织修复的标准，确定我们相对于这些目标的位置和可能 可接受性的阈值值，并检查效率，手术处理和依恋的问题，成本 制造和预计临床前和临床试验的时间。通过不断质疑我们的 一路走来，我们应该能够更好地评估组织工程方法， 协助资助机构最有效地将其可用的研究资金用于组织工程， 并加快开发有用的产品来临床使用。