Robotic Simulation: Tissue Function with In Vivo Motions

机器人模拟：体内运动的组织功能

• 批准号: 7230239
• 负责人: DAVID L BUTLER
• 金额: $ 18.63万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7230239
• 关键词: Address; Anterior; Anterior Cruciate Ligament; Benchmarking; Calibration; Cartilage; Condition; Controlled Study; Coupling; Data; Degenerative polyarthritis; Eating; Fiber; Figs - dietary; Gait; Genus Capra; Goals; Goat; Human; In Vitro; Joints; Knee; Knowledge; Laboratories; Lateral meniscus structure; Length; Ligaments; Limb structure; Measures; Medial; Medial meniscus structure; Meniscus structure of joint; Monitor; Motion; Operative Surgical Procedures; Orthopedics; Patients; Phase; Physiological; Positioning Attribute; Property; Relative (related person); Repair Complex; Research Activity; Research Personnel; Robot; Robotics; Rotation; Simulate; Specimen; Stress; Structure; Surface; Technology; Tendon structure; Testing; Thinking; Tissue Engineering; Tissues; Transducers; Translations; Ultrasonics; Variant; bone; collateral ligament; design; human subject; improved; in vivo; injured; injury and repair; insight; instrument; kinematics; programs; reconstruction; repaired; research study; restraint; simulation; soft tissue; voltage

DESCRIPTION (provided by applicant): The anterior cruciate ligament (ACL) and medial meniscus (MM) are frequently injured knee structures. Losing the functions of either or both of these structures can dramatically alter joint kinematics, causing cartilage damage and the onset of degenerative joint disease and osteoarthritis in the longer term. While investigators are beginning to accurately characterize normal knee kinematics and ligament surface strains in human subjects, critically important tissue forces and contact stresses are impossible to measure in humans without direct calibration. To address this concern, the investigators propose to determine ACL forces and meniscus contact stresses in the goat knee for selected in vivo activities in a robot. We seek to test the global hypothesis that in vivo tissue forces and deformations and tissue-tissue interactions can be predicted by accurately reproducing in vivo knee kinematics in an in vitro setting. To test this global hypothesis, we will examine 5 specific aims: Aim 1: Instrument the goat knee at surgery with ultrasonic crystals and tissue force transducers to precisely monitor relative bone positions and transducer voltages during controlled in vivo activities after surgery. Aim 2: In the laboratory, transform the relative bone positions into joint kinematics to drive a robot to reproduce the knee state during these in vivo activities. Compare actual and simulated joint rotations and translations to determine if in vivo kinematics have been recreated within an acceptable tolerance during the stance phase of gait for each activity. Aim 3: Compare in vivo and in vitro tissue force transducer voltages to determine if in vivo voltages have been recreated within an acceptable tolerance during the stance phase of gait for each activity. Aim 4: Perform selective cutting experiments to study how capsular, ligamentous, and meniscus structures influence the functions of the ACL and menisci for simulated in vivo activities. Aim 5: Calibrate the force transducers to determine ACL forces and meniscus contact stresses for each in activity. Measure the associated tissue deformations for each in vivo activity. This research program will dramatically improve our understanding of normal knee motion and forces. These technologies will serve as a platform for studying injury, repair and reconstruction in the knee and other joints and to develop functional tissue engineering parameters.

描述（由申请人提供）：前十字韧带（ACL）和内侧半月板（MM）是经常受伤的膝关节结构。 失去其中一个或两个结构的功能会极大地改变关节运动学，从长远来看会导致软骨损伤以及退行性关节疾病和骨关节炎的发作。虽然研究人员开始准确地表征人类受试者的正常膝关节运动学和韧带表面应变，但如果不直接校准，就不可能测量人体中至关重要的组织力和接触应力。为了解决这个问题，研究人员建议确定山羊膝关节中 ACL 力和半月板接触应力，以用于机器人的选定体内活动。我们力求 检验体内组织力和变形以及组织与组织相互作用的总体假设 可以通过在体外环境中准确再现体内膝关节运动学来预测。为了检验这一全局假设，我们将研究 5 个具体目标： 目标 1：在手术中使用超声波晶体和组织力传感器对山羊膝关节进行仪器仪表，以在术后受控体内活动期间精确监测相对骨位置和传感器电压。 目标 2：在实验室中，将相对骨骼位置转换为关节运动学，以驱动机器人在这些体内活动中重现膝关节状态。比较实际和模拟的关节旋转和平移，以确定在每项活动的步态站立阶段是否在可接受的容差范围内重新创建了体内运动学。 目标 3：比较体内和体外组织力传感器电压，以确定在每次活动的步态站立阶段是否在可接受的容差范围内重新创建了体内电压。 目标 4：进行选择性切割实验，研究囊膜、韧带和半月板结构如何影响 ACL 和半月板的功能，以模拟体内活动。 目标 5：校准力传感器以确定每个活动的 ACL 力和半月板接触应力。测量每个体内活动的相关组织变形。 该研究计划将极大地提高我们对正常膝关节运动和力的理解。这些技术将作为研究膝关节和其他关节损伤、修复和重建以及开发功能性组织工程参数的平台。