Robotic Simulation: Tissue Function with In Vivo Motions
机器人模拟:体内运动的组织功能
基本信息
- 批准号:7230239
- 负责人:
- 金额:$ 18.63万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-03-01 至 2009-02-28
- 项目状态:已结题
- 来源:
- 关键词:AddressAnteriorAnterior Cruciate LigamentBenchmarkingCalibrationCartilageConditionControlled StudyCouplingDataDegenerative polyarthritisEatingFiberFigs - dietaryGaitGenus CapraGoalsGoatHumanIn VitroJointsKneeKnowledgeLaboratoriesLateral meniscus structureLengthLigamentsLimb structureMeasuresMedialMedial meniscus structureMeniscus structure of jointMonitorMotionOperative Surgical ProceduresOrthopedicsPatientsPhasePhysiologicalPositioning AttributePropertyRelative (related person)Repair ComplexResearch ActivityResearch PersonnelRobotRoboticsRotationSimulateSpecimenStressStructureSurfaceTechnologyTendon structureTestingThinkingTissue EngineeringTissuesTransducersTranslationsUltrasonicsVariantbonecollateral ligamentdesignhuman subjectimprovedin vivoinjuredinjury and repairinsightinstrumentkinematicsprogramsreconstructionrepairedresearch studyrestraintsimulationsoft tissuevoltage
项目摘要
DESCRIPTION (provided by applicant): The anterior cruciate ligament (ACL) and medial meniscus (MM) are frequently injured knee structures. Losing the functions of either or both of these structures can dramatically alter joint kinematics, causing cartilage damage and the onset of degenerative joint disease and osteoarthritis in the longer term. While investigators are beginning to accurately characterize normal knee kinematics and ligament surface strains in human subjects, critically important tissue forces and contact stresses are impossible to measure in humans without direct calibration. To address this concern, the investigators propose to determine ACL forces and meniscus contact stresses in the goat knee for selected in vivo activities in a robot. We seek to
test the global hypothesis that in vivo tissue forces and deformations and tissue-tissue interactions
can be predicted by accurately reproducing in vivo knee kinematics in an in vitro setting. To test this global hypothesis, we will examine 5 specific aims:
Aim 1: Instrument the goat knee at surgery with ultrasonic crystals and tissue force transducers to precisely monitor relative bone positions and transducer voltages during controlled in vivo activities after surgery.
Aim 2: In the laboratory, transform the relative bone positions into joint kinematics to drive a robot to reproduce the knee state during these in vivo activities. Compare actual and simulated joint rotations and translations to determine if in vivo kinematics have been recreated within an acceptable tolerance during the stance phase of gait for each activity.
Aim 3: Compare in vivo and in vitro tissue force transducer voltages to determine if in vivo voltages have been recreated within an acceptable tolerance during the stance phase of gait for each activity.
Aim 4: Perform selective cutting experiments to study how capsular, ligamentous, and meniscus structures influence the functions of the ACL and menisci for simulated in vivo activities.
Aim 5: Calibrate the force transducers to determine ACL forces and meniscus contact stresses for each in activity. Measure the associated tissue deformations for each in vivo activity.
This research program will dramatically improve our understanding of normal knee motion and forces. These technologies will serve as a platform for studying injury, repair and reconstruction in the knee and other joints and to develop functional tissue engineering parameters.
描述(由申请人提供):前交叉韧带(ACL)和内侧半月板(MM)是经常受伤的膝关节结构。失去其中一种或两种结构的功能会显著改变关节运动学,导致软骨损伤,长期发生退行性关节疾病和骨关节炎。虽然研究人员开始准确地描述人类受试者的正常膝关节运动学和韧带表面应变,但如果没有直接校准,至关重要的组织力和接触应力是不可能测量的。为了解决这一问题,研究人员建议在机器人中选择体内活动时确定山羊膝盖的前交叉韧带力和半月板接触应力。我们寻求
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('DAVID L BUTLER', 18)}}的其他基金
Gulf States Collaborative Center for Health Policy Research (Gulf States CC)
海湾国家卫生政策研究合作中心(海湾国家 CC)
- 批准号:
8605969 - 财政年份:2013
- 资助金额:
$ 18.63万 - 项目类别:
A Developmentally-Based Tissue Engineering Approach to Improve Tendon Repair
一种基于发育的组织工程方法来改善肌腱修复
- 批准号:
7891388 - 财政年份:2009
- 资助金额:
$ 18.63万 - 项目类别:
A Developmentally-Based Tissue Engineering Approach to Improve Tendon Repair
一种基于发育的组织工程方法来改善肌腱修复
- 批准号:
8082749 - 财政年份:2009
- 资助金额:
$ 18.63万 - 项目类别:
A Developmentally-Based Tissue Engineering Approach to Improve Tendon Repair
一种基于发育的组织工程方法来改善肌腱修复
- 批准号:
8293428 - 财政年份:2009
- 资助金额:
$ 18.63万 - 项目类别:
A Developmentally-Based Tissue Engineering Approach to Improve Tendon Repair
一种基于发育的组织工程方法来改善肌腱修复
- 批准号:
7991696 - 财政年份:2009
- 资助金额:
$ 18.63万 - 项目类别:
A Developmentally-Based Tissue Engineering Approach to Improve Tendon Repair
一种基于发育的组织工程方法来改善肌腱修复
- 批准号:
7753953 - 财政年份:2009
- 资助金额:
$ 18.63万 - 项目类别:
Robotic Simulation: Tissue Function with In Vivo Motions
机器人模拟:体内运动的组织功能
- 批准号:
7098266 - 财政年份:2006
- 资助金额:
$ 18.63万 - 项目类别:
Tissue Engineering Evaluation Criteria for Musculoskeletal Tissue Repair
肌肉骨骼组织修复的组织工程评价标准
- 批准号:
7225830 - 财政年份:2006
- 资助金额:
$ 18.63万 - 项目类别:
Tissue Engineering Evaluation Criteria for Musculoskeletal Tissue Repair
肌肉骨骼组织修复的组织工程评价标准
- 批准号:
7323582 - 财政年份:2006
- 资助金额:
$ 18.63万 - 项目类别:
Cell phenotype-controlled mechanical signaling of MSCs
MSC 的细胞表型控制的机械信号传导
- 批准号:
6801879 - 财政年份:2003
- 资助金额:
$ 18.63万 - 项目类别:
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