2006 Chemotactic Cytokines Gordon Conference

描述（由申请人提供）：在过去的几年里，研究已经涉及到一组特殊的细胞因子，称为趋化因子（趋化细胞因子）在各种生物过程中。利用转基因小鼠或中和抗体，研究人员已经证明了趋化因子系统在多种过程中的重要贡献，如白细胞的稳态运输、炎症、血管生成、癌症和发育。这种信息的爆炸导致了对趋化因子受体拮抗剂的积极研究。然而，进展缓慢，并且发现了与药物发现和趋化因子系统本身相关的各种基本科学问题。因此，一个庞大的研究群体已经形成，他们的成员对趋化细胞因子感兴趣，并且他们的背景非常不同。这些科学家将从直接交流思想的机会中受益匪浅，而戈登趋化细胞因子研究会议就是为了满足这一需求而设计的。这次会议将于2006年9月在法国奥索瓦举行。它将讨论趋化因子在发育，疾病（重点是炎症性疾病和癌症）和药物发现中的功能的基本方面。该活动将限制160人参加，并将具有国际特色，尽管预计大多数与会者将来自美国。会议发言人和主题的选择反映了该领域最新的前沿进展。1个完整的会议将专门讨论年轻研究者（初级教员/博士后）最新的突发新闻，另一个会议将讨论趋化因子在白细胞运输中的作用（重点是新的可视化技术）。会议还旨在让学生、博士后研究员和其他受训人员接触顶尖科学家。请提供支持，以帮助支付在欧洲会场的旅费和/或会议费用。

DESCRIPTION (provided by applicant): In the last few years, research has implicated a special group of cytokines known as chemokines (chemotactic cytokines) in diverse array of biological processes. Using genetically modified mice, or neutralizing antibodies, investigators have demostrated the essential contribution of the chemokine system to processes as diverse as homeostatic trafficking of leukocytes, inflammation, angiogenesis, cancer, and development. This explosion of information has led to an active search for chemokine receptor antagonists. However, progress has been slow, and a variety of fundametal scientific issues have been uncovered that relate both to drug discovery and to the chemokine system itself. Thus, a large community of investigators has evolved whose members are interested in chemotactic cytokines and who approach this interest from very diverse backgrounds. These scientists would benefit immensely from an opportunity to exchange ideas directly, and the Gordon Research Conference on Chemotactic Cytokines is designed to meet that need. This conference will meet in Aussois, France, in September 2006. It will discuss essential aspects of chemokine function in development, disease (with emphasis in inflammatory diseases and cancer), and drug discovery. It will be limited to 160 participants and will be international in flavor, although most attendees are expected to be from the US. Conference speakers and topics have been chosen to reflect the newest cutting edge advances in the field. 1 full session will be dedicated to late breaking news by young investigators (junior faculty/postdocs) and another session to discuss advances in the role of chemokines in leukocyte trafficking (with emphasis on novel visualization technology). The conference is also intended to expose students, postdoctoral fellows, and other trainees to leading scientists. Support is requested to help cover the travel and/or conference fee costs at the European venue.