2006 Chemotactic Cytokines Gordon Conference

描述（由申请人提供）：在过去的几年中，研究表明一组特殊的细胞因子被称为趋化因子（趋化性细胞因子），参与多种生物过程。研究人员使用基因修饰的小鼠或中和抗体，证明了趋化因子系统对白细胞稳态运输、炎症、血管生成、癌症和发育等多种过程的重要贡献。这种信息爆炸导致了对趋化因子受体拮抗剂的积极搜索。然而，进展一直很缓慢，并且已经发现了与药物发现和趋化因子系统本身相关的各种基础科学问题。因此，一个庞大的社区的研究人员已经发展，其成员有兴趣在趋化细胞因子和谁接近这个兴趣从非常不同的背景。这些科学家将从直接交流思想的机会中受益匪浅，戈登趋化性细胞因子研究会议旨在满足这一需求。该会议将于2006年9月在法国奥苏瓦举行。它将讨论趋化因子在发育，疾病（重点是炎症性疾病和癌症）和药物发现中的功能的基本方面。它将被限制在160名参与者，并将是国际风味，虽然大多数与会者预计将来自美国。会议发言人和主题的选择反映了该领域的最新前沿进展。一个完整的会议将致力于年轻研究人员（初级教师/博士后）的最新新闻，另一个会议将讨论趋化因子在白细胞运输中的作用（重点是新的可视化技术）。会议还旨在让学生、博士后研究员和其他受训人员接触领先的科学家。请求提供支助，以帮助支付欧洲会场的差旅费和/或会议费。

DESCRIPTION (provided by applicant): In the last few years, research has implicated a special group of cytokines known as chemokines (chemotactic cytokines) in diverse array of biological processes. Using genetically modified mice, or neutralizing antibodies, investigators have demostrated the essential contribution of the chemokine system to processes as diverse as homeostatic trafficking of leukocytes, inflammation, angiogenesis, cancer, and development. This explosion of information has led to an active search for chemokine receptor antagonists. However, progress has been slow, and a variety of fundametal scientific issues have been uncovered that relate both to drug discovery and to the chemokine system itself. Thus, a large community of investigators has evolved whose members are interested in chemotactic cytokines and who approach this interest from very diverse backgrounds. These scientists would benefit immensely from an opportunity to exchange ideas directly, and the Gordon Research Conference on Chemotactic Cytokines is designed to meet that need. This conference will meet in Aussois, France, in September 2006. It will discuss essential aspects of chemokine function in development, disease (with emphasis in inflammatory diseases and cancer), and drug discovery. It will be limited to 160 participants and will be international in flavor, although most attendees are expected to be from the US. Conference speakers and topics have been chosen to reflect the newest cutting edge advances in the field. 1 full session will be dedicated to late breaking news by young investigators (junior faculty/postdocs) and another session to discuss advances in the role of chemokines in leukocyte trafficking (with emphasis on novel visualization technology). The conference is also intended to expose students, postdoctoral fellows, and other trainees to leading scientists. Support is requested to help cover the travel and/or conference fee costs at the European venue.