Gordon Conference on "Phosphorylation and G Protein Signaling Networks"

描述(由申请人提供)： 我们要求为戈登研究会议(GRC)的磷酸化和G蛋白信号网络的运作提供部分资金支持。该会议的前身为“第二信使和蛋白质磷酸化”，自1970年以来每年举行一次，一直是展示信号转导新发现的主要场所。从会议一开始就发起和参加会议的研究人员是信号转导领域的奠基人，包括几位诺贝尔奖获得者(例如，厄尔·萨瑟兰、阿尔·奥伊尔曼、斯坦利·科恩、埃德温·克雷布斯、埃德蒙·费舍尔、保罗·诺尔斯)。会议的重点是调节细胞生长、分化、存活和新陈代谢的信号转导机制。充分了解这些信号机制具有重要的科学和临床意义，因为它们的失败直接导致了影响全球数百万人的当代健康问题，如糖尿病、肥胖症、癌症、老龄化、传染病、心血管疾病、神经退行性疾病和发育障碍。会议主题从机械论的角度涵盖细胞内信号通路网络，并通过重点研究蛋白质共价修饰、蛋白质-蛋白质和蛋白质-核酸相互作用以及由小分子效应器控制的研究，继续突出前沿发现。新英格兰大学于2005年成为这次会议的新会址，并提供了一个乡村和残障人士可进入的场所，以促进与会者之间的开放互动。2006年会议将于6月11日周日晚至6月16日周四晚结束。会议鼓励演讲者整合生化、结构、细胞生物学和基因组学方法，全面了解与疾病有关的信号机制的分子方面。选择了两位全体演讲者为会议做准备，并要求与会者从化学-生物界面的角度思考信号转导。会议将由8场会议组成，每场会议有一名讨论负责人和3-5名发言者，他们是从最近做出重要贡献的研究人员中挑选出来的。至少45%的受邀发言者是妇女或少数群体成员，23%的受邀发言者是新的调查员(助理/协会)。级别)。每节课的演讲者将发展信号转导方面的重要范例。重点将放在对确定的分子机制及其对疾病的影响和潜在治疗策略的结构和功能的理解上。联席主席将从申请者中挑选135名参与者，包括来自工业界和学术界的代表、资深科学家、博士后研究员和研究生。将特别努力通过直接电子邮件计划从行业中招募少数族裔参与者和参与者。将鼓励参与者每天下午展示关于新的和有趣的结果的海报。重要的是，这次会议为年轻研究人员提供了一个论坛，让他们看到基础科学研究与应用科学方法设计有效的人类疾病干预措施之间的联系。为强调这一目标，将在主要会议期间选择8个补充会议主题的海报陈述作为简短的口头陈述。

DESCRIPTION (provided by applicant): We request partial funding support for operation of the Gordon Research Conference (GRC) on Phosphorylation and G protein Signaling Networks. This conference, formerly known as "Second Messengers and Protein Phosphorylation" has been held annually since 1970, and has been a premier venue for the presentation of new discoveries in signal transduction. Investigators who initiated and attended this meeting from its inception were leaders who established the field of signal transduction, including several who have received Nobel Prizes (e.g., Earl Sutherland, Al Oilman, Stanley Cohen, Edwin Krebs, Edmond Fischer, Paul Nurse). The conference focuses on signal transduction mechanisms that regulate cell growth, differentiation, survival, and metabolism. A full understanding of these signaling mechanisms is scientifically and clinically important because their failure plays a direct role in contemporary health problems that affect millions of people worldwide, such as diabetes, obesity, cancer, aging, infectious disease, cardiovascular disease, neurodegeneration, and developmental disorders. Meeting topics cover networks of intracellular signaling pathways from a mechanistic viewpoint, and continue to highlight cutting edge discoveries by emerging from studies focused on protein covalent modifications, protein-protein and protein-nucleic acid interactions, and control by small molecule effectors. The University of New England became the new site for this meeting in 2005, and provides a rustic and handicapped-accessible venue to promote open interaction among participants. The 2006 meeting will be held from Sunday night June 11 and end on Thursday evening June 16. The speakers are encouraged to integrate biochemical, structural, cell-biological, and genomic approaches that provide a comprehensive understanding of the molecular aspects of signaling mechanisms as they relate to disease. Two plenary speakers were selected to set the stage for the conference and to challenge the participants to think about signal transduction from perspectives of the chemistry-biology interface. The conference will consist of 8 sessions, each with a discussion leader and 3-5 speakers, selected from investigators who have made important recent contributions. At least 45% of the invited speakers are either women or members of minority groups and 23% of invited speakers are new investigators (Asst/Assoc. level). Speakers in each session will develop the important paradigms in signal transduction. The emphasis will be on structural and functional understanding of the defining molecular mechanisms and their implications for disease and potential treatment strategies. The co-chairs will select 135 participants from applicants, including representatives from industry and academia, senior scientists, postdoctoral fellows and graduate students. A special effort will be made to recruit minority participants and participants from industry by a direct emailing program. Participants will be encouraged to present posters on new and interesting results each afternoon. Importantly, the conference provides a forum for young investigators to see the connection between fundamental scientific inquiry and the application of scientific methods to the design of efficacious interventions for human disease. To emphasize this goal, 8 poster presentations that complement the themes of the meeting will be selected for short oral presentations during the main sessions.