International Workshop on Skeletal Growth

描述(申请人提供)：骨骼生长是人类发育的基本元素，主要发生在生长板结构中，位于生长骨骼末端附近，模板软骨在这里以高度协调、同步和严格控制的方式产生、降解并被骨骼取代。许多领域的最新进展，包括人类和小鼠遗传学、发育和基质生物学以及信号转导，为了解骨骼生长的本质提供了许多线索；但许多问题仍然没有得到回答，同时也提出了新的问题，这些进展的全部影响尚未实现。 拟议的骨骼生长板国际研讨会将直接讨论哺乳动物生长板的分子和细胞生物学、它的调节和它的干扰。该研讨会源于2001年在圣安东尼奥举行的一次非常成功的NIH赞助的生长板国际会议，该研讨会将剖析当前的教条，并试图开发新的范例来理解生长板的功能和功能障碍。该讲习班将围绕生长板软骨细胞的生命周期进行概念性组织。每一次会议将由一名专家介绍，专家将总结当前的概念，提出需要解决的重要问题，并在相关发言后领导深入讨论。这种研讨会形式预计将挑战与会者批判性地探索骨骼生长，并开发新的方法来概念性地构建和实验地接近生长板生物学。重点将放在整合跨学科、物种和实验系统的知识，以及适用于医学和牙科的基础科学和转化科学之间。讲习班将面向来自学术界和制药以及生物技术行业的基础和临床科学家、博士后研究员、研究生以及少数族裔。与会者的组合、高发言质量、研讨会形式、骨骼发育的跨学科性质以及丰富的讨论进展应有助于举办一次成功和有效的研讨会。它将于2006年6月11日至15日在俄勒冈州波特兰附近的Skamania Lodge举行。该讲习班的内容对NICHD、NIAMS和NIDCR的任务具有广泛的影响。

DESCRIPTION (provided by applicant): Skeletal growth is a fundamental element of human development that occurs primarily in growth plate structures located near the ends of growing bones where template cartilage is generated, degraded, and replaced by bone in a highly coordinated, synchronized, and tightly controlled fashion. Recent advances in many fields, including human and mouse genetics, developmental and matrix biology, as well as signal transduction, have provided much insight into the nature of skeletal growth; but many questions remain unanswered, while new ones have been raised, and the full impact of the advances has yet to be realized. The proposed International Workshop on the Skeletal Growth Plate will directly tackle the molecular and cellular biology of the mammalian growth plate, its regulation, and its disturbances. Growing out of a very successful NIH-sponsored International Conference on the Growth Plate held in San Antonio in 2001, the Workshop will dissect current dogma and attempt to develop new paradigms for understanding growth plate function and dysfunction. The Workshop will be conceptually organized around the life cycle of the growth plate chondrocyte. Each session will be introduced by an expert, who will summarize current concepts, pose important questions to address, and lead in-depth discussions following relevant presentations. This workshop format is expected to challenge participants to critically explore skeletal growth and develop novel ways to conceptually frame and experimentally approach growth plate biology. Emphasis will be placed on integrating knowledge across disciplines, species, and experimental systems, and between basic and translational science applicable to medicine and dentistry. The Workshop will be targeted to basic and clinical scientists from academia and pharmaceutical as well as biotechnology industries, postdoctoral fellows, graduate students, as well as minorities. The participant mix, high speaker quality, workshop format, interdisciplinary nature of skeletal growth, as well as wealth of advances for discussion should contribute to a successful and effective workshop. It will be held at the Skamania Lodge near Portland, Oregon on June 11-15, 2006. The content of this Workshop has broad implications related to the missions of NICHD, NIAMS, and NIDCR.