International Workshop on Skeletal Growth

骨骼生长国际研讨会

• 批准号: 7112185
• 负责人: WILLIAM A HORTON
• 金额: $ 1.7万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7112185
• 关键词: bone development; chondrocytes; epiphysis; skeletal system; travel; workshop

DESCRIPTION (provided by applicant): Skeletal growth is a fundamental element of human development that occurs primarily in growth plate structures located near the ends of growing bones where template cartilage is generated, degraded, and replaced by bone in a highly coordinated, synchronized, and tightly controlled fashion. Recent advances in many fields, including human and mouse genetics, developmental and matrix biology, as well as signal transduction, have provided much insight into the nature of skeletal growth; but many questions remain unanswered, while new ones have been raised, and the full impact of the advances has yet to be realized. The proposed International Workshop on the Skeletal Growth Plate will directly tackle the molecular and cellular biology of the mammalian growth plate, its regulation, and its disturbances. Growing out of a very successful NIH-sponsored International Conference on the Growth Plate held in San Antonio in 2001, the Workshop will dissect current dogma and attempt to develop new paradigms for understanding growth plate function and dysfunction. The Workshop will be conceptually organized around the life cycle of the growth plate chondrocyte. Each session will be introduced by an expert, who will summarize current concepts, pose important questions to address, and lead in-depth discussions following relevant presentations. This workshop format is expected to challenge participants to critically explore skeletal growth and develop novel ways to conceptually frame and experimentally approach growth plate biology. Emphasis will be placed on integrating knowledge across disciplines, species, and experimental systems, and between basic and translational science applicable to medicine and dentistry. The Workshop will be targeted to basic and clinical scientists from academia and pharmaceutical as well as biotechnology industries, postdoctoral fellows, graduate students, as well as minorities. The participant mix, high speaker quality, workshop format, interdisciplinary nature of skeletal growth, as well as wealth of advances for discussion should contribute to a successful and effective workshop. It will be held at the Skamania Lodge near Portland, Oregon on June 11-15, 2006. The content of this Workshop has broad implications related to the missions of NICHD, NIAMS, and NIDCR.

描述（由申请人提供）：骨骼生长是人类发育的基本要素，主要发生在生长板结构附近的生长板结构中，在生长骨骼的末端，在这些骨骼的末端产生了模板软骨，并在高度协调的，同步的，紧密控制的方式中被骨骼代替。 许多领域的最新进展，包括人类和小鼠遗传学，发育和基质生物学以及信号转导，都为骨骼生长的性质提供了很大的了解。但是许多问题尚未解决，而新的问题已经提出，并且进步的全部影响尚未实现。 拟议的关于骨骼生长板的国际研讨会将直接处理哺乳动物生长板的分子和细胞生物学，其调节及其干扰。 该研讨会从2001年在圣安东尼奥举行的非常成功的NIH赞助国际会议上成长，该研讨会将剖析当前的教条，并试图开发新的范式来了解增长板功能和功能障碍。 研讨会将在概念上组织生长板软骨细胞的生命周期。 每个会议都将由专家介绍，专家将总结当前的概念，提出重要的问题，并在相关演示后进行深入讨论。 预计这种研讨会格式将挑战参与者批判性地探索骨骼生长，并开发出概念上和实验生长板生物学的新颖方式。 将重点放在整合跨学科，物种和实验系统的知识，以及适用于医学和牙科的基础科学和转化科学之间。 该研讨会将针对来自学术界和制药的基础和临床科学家以及生物技术行业，博士后研究员，研究生以及少数群体。 参与者组合，高级演讲者的质量，研讨会格式，骨骼增长的跨学科性质以及讨论的丰富进展应为成功有效的研讨会做出贡献。 它将于2006年6月11日至15日在俄勒冈州波特兰附近的Skamania Lodge举行。该研讨会的内容与NICHD，NIAMS和NIDCR的任务有关。