Bioenergetic and Metabolic Consequences of the Loss of Ovarian Function in Women
女性卵巢功能丧失的生物能和代谢后果
基本信息
- 批准号:8367337
- 负责人:
- 金额:$ 50.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-20 至 2017-05-31
- 项目状态:已结题
- 来源:
- 关键词:Adverse effectsAgeAge FactorsAgingAging-Related ProcessAgonistAmericanAnimalsAttenuatedBioenergeticsBiologicalBiological MarkersBone DensityChronic DiseaseClinicalColon CarcinomaCoronary heart diseaseDiseaseEnergy MetabolismEstrogensExerciseFailureFastingFatty acid glycerol estersFemaleFigs - dietaryFoodFunctional disorderGoalsGonadotropin Hormone Releasing HormoneGuidelinesHealthHumanHypertensionIndirect CalorimetryInflammationInflammatoryInstructionInsulin ResistanceInterventionLabelLifeMaintenanceMalignant NeoplasmsMeasuresMediatingMenopauseMenstrual cycleMental DepressionMetabolicMetabolic ControlMetabolic syndromeMuscleNon-Insulin-Dependent Diabetes MellitusObesityObservational StudyOrchiectomyOsteoporosisOvarianOvarian AblationOvariectomyPhysical activityPlacebosPlayPrincipal InvestigatorProspective StudiesRandomizedRelative (related person)ReportingResearchRestRiskRoleSecondary toSerumSleepStrokeTechniquesTestosteroneTimeWaterWeight GainWomanabdominal fatage relatedagedbasebone losscytokinedisorder riskenergy balancefeedingfitnessgonad functionmalemalignant breast neoplasmmenmortalitypreventprimary outcomeprogramsresponserestorationsecondary outcomeskeletal
项目摘要
Gonadal aging plays a distinct role in mediating some of the biological changes ascribed to the aging
process. An example of this is the accelerated bone loss due to ovarian failure at the time of the menopause,
which can be effectively mitigated with restoration of estrogens until other non-gonadal aging factors trigger
a decline. Because it is difficult to isolate the consequences of gonadal aging from chronologic aging, it is not
clear to what extent the loss of gonadal function increases risk for age-related diseases other than
osteoporosis. There is compelling evidence from studies of female and male animals that the loss of gonadal
function causes a dramatic decline of 30% to 80% in spontaneous physical activity. In females, but not
males, this leads to accelerated weight gain, a marked increase in abdominal fat, and metabolic dysfunction.
One prospective study of women followed through the menopausal transition suggests that physical activity
and the maintenance of energy balance are also regulated by gonadal function in humans. In this context,
the primary goal of the UCAMC SCOR clinical project is to use a controlled intervention approach to
determine whether the suppression of ovarian function in women approaching the menopause causes a
marked decline in physical activity. Additional goals are to assess changes in other components of energy
expenditure, determine whether the disruption of energy balance is associated with changes in biomarkers of
disease risk, and determine whether programmed exercise can prevent these changes. To achieve these
aims, 66 women aged 45 to 50 years with normal menstrual cycle function will be randomized to receive 6
months of placebo, gonadotropin releasing hormone agonist (GnRHAc), or GnRHAG+exercise intervention.
The primary outcome will be physical activity energy expenditure (PAEE), calculated from total daily energy
expediture (TEE; by doubly-labeled water) with adjustment for the thermic effect of food and resting EE
(REE; by indirect calorimetry). The global hypothesis is that the suppression of ovarian function with GnRHAG
in women will cause a decrease in TEE due to decreased PAEE and, possibly, a decrease in REE.
RELEVANCE (See instructions):
A decline in PAEE secondary to the loss of gonadal function could have diverse adverse effects on health
because low physical activity is associated with all-cause mortality, coronary heart disease, stroke, type 2
diabetes, certain cancers, depression, etc. Moreover, this would be expected to have a greater adverse
effect in women than in men, because the loss of gonadal function occurs at an earlier age in women.
性腺老化在调节某些归因于衰老的生物学变化方面起着明显的作用。
进程。这方面的一个例子是绝经时卵巢衰竭导致的加速骨质流失,
雌激素的恢复可以有效地缓解这种症状,直到其他非性腺衰老因子触发
一种衰落。因为很难将性腺老化的后果与时间上的衰老分开,所以它不是
明确性腺功能丧失在多大程度上会增加患其他年龄相关疾病的风险
骨质疏松。有令人信服的证据表明,对雌性和雄性动物的研究表明,性腺的丧失
机能导致自发性体力活动急剧下降30%至80%。在女性身上,但不是
男性,这会导致体重加速增加,腹部脂肪显著增加,并导致代谢障碍。
一项对绝经期妇女的前瞻性研究表明,体力活动
而维持能量平衡也受人类性腺功能的调节。在这方面,
UCAMC SCOR临床项目的主要目标是使用受控干预方法来
确定接近更年期的女性卵巢功能抑制是否会导致
体力活动明显减少。其他目标是评估其他能源成分的变化
决定能量平衡的破坏是否与生物标记物的变化有关
疾病风险,并确定程序化运动是否可以防止这些变化。要实现这些目标
AIMS,66名年龄在45岁至50岁之间、月经周期功能正常的女性将随机接受6
安慰剂、促性腺激素释放激素激动剂(GnRHAc)或GnRHAG+运动干预。
主要结果将是体力活动能量消耗(PAEE),从每天的总能量计算
通过调整食物和休息EE的热效应来加速(T形三通;双标记水)
(Ree;间接量热法)。全球假说是GnRHAG对卵巢功能的抑制
在女性中,由于PAEE的降低以及可能的REE的降低,会导致TEE的下降。
相关性(请参阅说明):
继发于性腺功能丧失的PAEE下降可能会对健康产生各种不利影响
因为低体力活动与全因死亡率、冠心病、中风、2型有关
糖尿病、某些癌症、抑郁症等。此外,这可能会有更大的不良影响
对女性的影响大于对男性的影响,因为性腺功能丧失发生在女性年龄较早的时候。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Wendy M Kohrt其他文献
Addressing the gaps: sex differences in osteoarthritis of the knee
- DOI:
10.1186/2042-6410-4-4 - 发表时间:
2013-01-01 - 期刊:
- 影响因子:5.100
- 作者:
Barbara D Boyan;Laura L Tosi;Richard D Coutts;Roger M Enoka;David A Hart;Daniel P Nicolella;Karen J Berkley;Kathleen A Sluka;C Kent Kwoh;Mary I O’Connor;Wendy M Kohrt;Eileen Resnick - 通讯作者:
Eileen Resnick
Wendy M Kohrt的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Wendy M Kohrt', 18)}}的其他基金
Enhancing Skeletal Adaptation to Exercise by Attenuating the Acute Disruption of Calcium Homeostasis During Exercise
通过减轻运动过程中钙稳态的急性破坏来增强骨骼对运动的适应
- 批准号:
10251565 - 财政年份:2021
- 资助金额:
$ 50.2万 - 项目类别:
Enhancing Skeletal Adaptation to Exercise by Attenuating the Acute Disruption of Calcium Homeostasis During Exercise
通过减轻运动过程中钙稳态的急性破坏来增强骨骼对运动的适应
- 批准号:
10545712 - 财政年份:2021
- 资助金额:
$ 50.2万 - 项目类别:
Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center
身体活动联盟分子传感器 - 科罗拉多临床中心
- 批准号:
10840187 - 财政年份:2016
- 资助金额:
$ 50.2万 - 项目类别:
Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center
身体活动联盟分子传感器 - 科罗拉多临床中心
- 批准号:
10320753 - 财政年份:2016
- 资助金额:
$ 50.2万 - 项目类别:
Molecular Transducers of Physical Activity Consortium - Colorado Clinical Center
身体活动联盟分子传感器 - 科罗拉多临床中心
- 批准号:
10265087 - 财政年份:2016
- 资助金额:
$ 50.2万 - 项目类别:
Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function
性腺功能丧失的生物能和代谢后果
- 批准号:
8344030 - 财政年份:2012
- 资助金额:
$ 50.2万 - 项目类别:
Bioenergetic and metabolic consequences of the loss of ovarian function in women
女性卵巢功能丧失的生物能和代谢后果
- 批准号:
10225533 - 财政年份:2012
- 资助金额:
$ 50.2万 - 项目类别:
Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function
性腺功能丧失的生物能和代谢后果
- 批准号:
10225529 - 财政年份:2012
- 资助金额:
$ 50.2万 - 项目类别:
Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function
性腺功能丧失的生物能和代谢后果
- 批准号:
8904339 - 财政年份:2012
- 资助金额:
$ 50.2万 - 项目类别:
Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function
性腺功能丧失的生物能和代谢后果
- 批准号:
10456782 - 财政年份:2012
- 资助金额:
$ 50.2万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 50.2万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 50.2万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 50.2万 - 项目类别:
Fellowship
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 50.2万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 50.2万 - 项目类别:
Continuing Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 50.2万 - 项目类别:
Standard Grant
The economics of (mis)information in the age of social media
社交媒体时代(错误)信息的经济学
- 批准号:
DP240103257 - 财政年份:2024
- 资助金额:
$ 50.2万 - 项目类别:
Discovery Projects
How age & sex impact the transcriptional control of mammalian muscle growth
你多大
- 批准号:
DP240100408 - 财政年份:2024
- 资助金额:
$ 50.2万 - 项目类别:
Discovery Projects
Supporting teachers and teaching in the age of Artificial Intelligence
支持人工智能时代的教师和教学
- 批准号:
DP240100111 - 财政年份:2024
- 资助金额:
$ 50.2万 - 项目类别:
Discovery Projects
Enhancing Wahkohtowin (Kinship beyond the immediate family) Community-based models of care to reach and support Indigenous and racialized women of reproductive age and pregnant women in Canada for the prevention of congenital syphilis
加强 Wahkohtowin(直系亲属以外的亲属关系)以社区为基础的护理模式,以接触和支持加拿大的土著和种族育龄妇女以及孕妇,预防先天梅毒
- 批准号:
502786 - 财政年份:2024
- 资助金额:
$ 50.2万 - 项目类别:
Directed Grant