Core-C-chronic hypoxia model

这个低氧-高碳酸血症核心将以不同的方式服务于该计划的4个项目。Core C将以标准化和一致的方式提供暴露于缺氧或高碳酸血症（或两者兼而有之）的小鼠（或大鼠）。此外，核心将促进研究人员之间的互动，并有助于产生新的合作调查途径，因为使用相同的模型来研究对长期和长期气候变化的反应和适应机制

This Hypoxia-Hypercapnia Core will serve the 4 Projects in the Program in various ways. Core C will provide mice (or rats) that have been exposed to hypoxia or hypercapnia (or both) in a standardized and consistent way. Moreover, the Core will promote interactions among the investigators and help generate new avenues of collaborative investigation because of the use of identical models to study mechanisms for response and adaptation to long-term and graded stress. The aims of this Core Facility are as follows: 1. To ensure a consistent experimental model of chronic hypoxia or hypercapnia or both for use in all four projects; 2. To train technicians and postdoctoral and help in tissue dissection and collection for all investigators whether brain, heart or kidney; 3. To continue to characterize the chronic hypoxia-hypercapnia model in order to better understand the implications of novel findings that arise during the course of this program; 4. To develop comparable models of chronic hypoxia or hypercapnia in mice with genetic alterations (e.g. Knock-out such as NHE-/-) to propose specific mechanisms for adaptation or injury; 5. To help investigators in the design of experiments requiring chronic exposure of cells in culture for an extended period of time in hypoxia, hypercapnia or both.