Training Program in Molecular Medicine

项目总结 2006年，耶鲁大学启动了创新医学研究学者计划(MRSP)，其使命是 提供分子生物学、细胞生物学等核心基础科学概念的博士生培训， 生物化学、遗传学、生理学、药理学和病理学，与密集接触 专门为博士生设计的以医学为导向的课程和指导临床经验。这个 该培训的最终目标是使我们的学生成为未来生物医学领域的跨学科领导者。 理科，具有从事与临床相关的基础科学研究的独特能力 阐明疾病的分子机制。直到授予NIGMS T32支持的第一个五年 我们现在正在寻求延长中期战略计划，它得到了机构基金和基金的支持 由霍华德·休斯医学院(HHMI)提供。2013-2014年后终止HHMI支持 学年，以及继续这一非常成功的正在进行的项目的愿望构成了 申请分子医学(MM)培训基金的第一个五年奖，该基金支持四个 每年的实习生时段。耶鲁大学支持所有生物医学一年级的博士生，因此 这所T32学校每年资助两名二年级和两名三年级学生。MRSP学生参加一个 旨在吸引博士生参加与医学相关的培训和经验的各种计划活动 在他们的研究生学习过程中。这些课程首先集中在正常的人体生理学，器官细胞 生物学和生物统计学，然后是人类病理生物学和药物发现，验证， 和临床试验。MRSP学生还可以选择与耶鲁大学MD一年级学生一起参加 每周一次的小团体生理学“案例会议”教程，在这些教程中，他们深入探讨生理学 特定疾病状态的基础。MRSP的基础是为期两年的指导临床 为学生提供深入接触人类疾病背后的科学和第一手资料的经验 与患者进行纵向接触，以一种不同于以往的方式来阐述疾病的机制基础 通过传统的课堂学习是可能的。除这些正式活动外，MRSP还提供 持续指导所有MRSP学员选择论文研究实验室和组装 学位论文委员会支持NIGMS分子医学计划提供培训的目标 基础生物医学科学，侧重于阐明人类疾病的机制。基于伟大的 已获录取的符合培训资助金资格的杰出学生申请加入MRSP 耶鲁大学生物医学博士项目，我们要求增加年度录取名额 从四个到六个，这样我们每年就可以支持三个二年级和三个三年级的学生。

PROJECT SUMMARY In 2006 Yale started the innovative Medical Research Scholars Program (MRSP) with the mission of providing broad and deep Ph.D. training in the core basic science concepts of molecular biology, cell biology, biochemistry, genetics, physiology, pharmacology, and pathology, integrated with intensive exposure to medically oriented coursework and mentored clinical experiences designed specifically for Ph.D. students. The ultimate goal of this training is to prepare our students to be future interdisciplinary leaders in the biomedical sciences, with a unique ability to pursue clinically relevant fundamental basic science inquiry aimed at elucidating the molecular mechanisms of disease. Until the award of the first five years of NIGMS T32 support that we are now seeking to renew, MRSP had been supported by a combination of institutional funds and funds provided by the Howard Hughes Medical Institute (HHMI). Termination of HHMI support after the 2013-2014 academic year, and the desire to continue this highly successful ongoing program constituted the rationale for applying for the first five-year award of this Molecular Medicine (MM) Training Grant, which supported four trainee slots per year. Yale University supports all first-year PhD students in the biomedical sciences, and thus this T32 supports two second-year and two thrid-year students each year. MRSP students participate in a variety of program activities designed to engage Ph.D. students in medically relevant training and experiences throughout their graduate studies. The classes focus first on normal human physiology, organ-based cell biology, and biostatistics, followed by human pathobiology and an introduction to drug discovery, validation, and clinical trials. MRSP students also have the option to participate with first-year Yale MD students in weekly small-group physiology “case conference” tutorials, in which they explore in depth the physiological underpinnings of particular disease states. The cornerstone of the MRSP is a two-year mentored clinical experience that provides students with in-depth exposure to the science behind human diseases and first-hand longitudinal encounters with patients to contextualize the mechanistic basis of disease in a way that is not possible through traditional classroom learning. In addition to these formal activities, the MRSP also provides ongoing mentoring to all MRSP trainees regarding selection of a thesis research laboratory and assembly of the dissertation committee to support the goal of the NIGMS Molecular Medicine program to provide training in the basic biomedical sciences with a focus on elucidating the mechanisms of human disease. Based on the great demand for admission into the MRSP by outstanding training-grant-eligible students already admitted to Yale's umbrella biomedical sciences PhD program, we are requesting an increase in the number of annual slots from four to six, which would allow us to support three second-year and three third-year students each year.