A Novel Waveform for Electrical Nerve Conduction Block

电神经传导阻滞的新型波形

• 批准号: 7058782
• 负责人: KEVIN L. KILGORE
• 金额: $ 29.99万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-15 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7058782
• 关键词: action potentials; analgesia; biomedical equipment development; clinical research; dogs; electrodes; electrostimulus; human subject; implant; medical implant science; miniature biomedical equipment; nerve injury; neural conduction; neural inhibition; neuromuscular disorder; nonhuman therapy evaluation; patient oriented research; peripheral nervous system; therapy adverse effect

DESCRIPTION (provided by applicant): An effective, quick-acting and quick-reversing means of blocking the conduction of action potentials in whole nerve would have many important clinical applications, such as the elimination of pain and the modulation of muscle spasticity. One potential method for achieving this type of nerve conduction block is to use high frequency alternating current delivered through electrodes surrounding the target nerve. In our currently funded project, we have determined that this method can block 100% of the motor response in motor nerves. The block is gradable and can be completely reversed within one second. We are now ready to take the next step toward practical clinical implementation of this technique. Therefore, the specific aims of the proposed project are to: 1) determine if the chronic block of nerve conduction is damaging to the nerve, 2) determine the specific parameters necessary to provide motor and sensory block in humans, and 3) complete the technical and regulatory effort necessary to proceed to widespread human application of this technique. Chronic nerve block will be applied to the peripheral nerves of dogs for four weeks using parameters and regimens based on anticipated human applications. The post-operative nerve histology will be the primary outcome measure that will be used to determine if there are any damaging effects of the chronically applied conduction block in-vivo. We expect that the conduction block will not damage peripheral nerve because it uses a very low charge delivery per phase and delivers a zero net charge to the tissue. In conjunction with the chronic animal study, we will commence acute human studies using: 1) explanted human nerves to determine the parameters necessary for conduction block in large diameter nerves, 2) acute intra-operative testing to determine if successful motor block can be accomplished in the presence of intact reflex circuits, and 3) short-term chronic experiments to determine the parameters necessary for complete pain block. At the end of the proposed three year project, we expect to have completed all of the necessary tasks to enable the application of electrical nerve conduction block in humans for the elimination of peripheral nerve pain and for the modulation of muscle spasticity. This research will provide a significant tool in our ongoing efforts to reduce disability and improve quality of life.

描述（由申请人提供）：阻止整个神经中动作电位传导的有效，快速和快速反转手段将具有许多重要的临床应用，例如消除疼痛和肌肉痉挛的调节。实现这类神经传导块的一种潜在方法是使用通过靶神经周围的电极传递的高频交替电流。在当前资助的项目中，我们确定这种方法可以阻止运动神经中运动反应的100％。该块是可分级的，可以在一秒钟内完全反转。现在，我们准备迈出下一步，朝着该技术的实际临床实施迈出。因此，拟议项目的具体目的是：1）确定神经传导的慢性阻滞是否损害了神经，2）确定提供人类提供运动和感觉障碍所必需的特定参数，3）完成该技术的广泛应用所必需的技术和调节努力。根据预期的人类应用，使用参数和方案将慢性神经阻滞应用于狗的周围神经四个星期。术后神经组织学将是用于确定慢性应用传导阻滞是否存在损害作用的主要结果指标。我们预计传导块不会损害周围神经，因为它使用每个相的电荷输送非常低，并向组织提供零净电荷。结合慢性动物研究，我们将开始进行急性人类研究：1）在大直径神经中开发的人类神经，以确定传导阻滞所必需的参数，2）急性术中术中测试以确定是否可以在存在完整的反射电路的情况下完成成功的运动障碍，并确定需要完成短期慢性量的痛苦。在拟议的三年项目结束时，我们预计将完成所有必要的任务，以便能够在人类中应用电神经传导块，以消除周围神经疼痛和调节肌肉痉挛。这项研究将为我们持续减少残疾和改善生活质量的努力提供重要的工具。