Multispectral II-Plate Diffuse Optical Breast Tomography

多光谱 II 板漫反射光学乳腺断层扫描

• 批准号: 7106463
• 负责人: ARJUN G. YODH
• 金额: $ 40.8万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106463
• 关键词: artificial intelligence; bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; charge coupled device camera; clinical research; diagnosis design /evaluation; female; fiber optics; human subject; image enhancement; mammography; noninvasive diagnosis; optical tomography; phantom model; three dimensional imaging /topography; visible light

DESCRIPTION (provided by applicant): The long-range goal of this competing continuation grant is to assess and improve the breast tumor diagnostic capabilities of diffuse optical tomography with near infrared light. Near-infrared diffuse optical tomography is based on the study of functional processes, and provides several unique measurable parameters with potential to enhance breast tumor sensitivity and specificity. The techniques utilize non-ionizing radiation, are non-invasive, and are technologically simple and fast. Tissue optical absorption coefficients provide access to blood dynamics, total hemoglobin concentration, blood oxygen saturation, water concentration and lipid content. These tissue properties are often substantially different in rapidly growing tumors. During this proposal cycle we assembled a parallel-plate soft-compression apparatus for diffuse optical tomography of breast, and we have began pilot clinical studies with the instrument at the Hospital of the University of Pennsylvania. Our pilot studies have clearly shown tumors are detectable and characterizable with the diffuse optical method; they can even be tracked during neoadjuvant chemotherapy. Our proposed work emphasizes hardware and software improvements, and then pushes for more and deeper clinical studies. In particular we will upgrade the source switching apparatus and detection CCD in order to improve speed by approximately a factor of 4. This will increase our spectral coverage by approximately 4, given the same measurement time. We will upgrade the breast table to improve our idefinition of tissue boundaries and increase our sensitivity to breast tissue near the chest wall. We will upgrade our software for reconstruction in many ways, but most importantly in ways that reduce artifacts near boundaries. We will continue pilot studies on normal subjects and tumor bearing patients, this time with more specific supporting information from radiologists and pathologists, and finally, we will have a unique opportunity to follow a group of patients undergoing neoadjuvant chemotherapy. If successful, these powerful new improvements will enhance the fidelity of the breast images, and the anatomical and functional information generated by the device will improve our ability to detect and specify the nature of breast tumors.

描述（由申请人提供）： 这项竞争性继续资助的长期目标是评估和提高近红外光漫射光学断层扫描的乳腺肿瘤诊断能力。近红外漫射光学断层扫描是基于功能过程的研究，并提供了几个独特的可测量的参数，有可能提高乳腺肿瘤的灵敏度和特异性。这些技术利用非电离辐射，是非侵入性的，技术上简单快捷。组织光吸收系数提供了对血液动力学、总血红蛋白浓度、血氧饱和度、水浓度和脂质含量的访问。这些组织特性在快速生长的肿瘤中通常是显著不同的。在这个建议周期，我们组装了一个平行板软压缩设备的扩散光学断层扫描的乳房，我们已经开始试点临床研究的仪器在宾夕法尼亚大学医院。我们的初步研究已经清楚地表明，肿瘤是可检测的，并与扩散光学方法的特点;他们甚至可以在新辅助化疗跟踪。我们提出的工作重点是硬件和软件的改进，然后推动更多和更深入的临床研究。特别是，我们将升级源切换装置和检测CCD，以便将速度提高约4倍。在相同的测量时间下，这将使我们的光谱覆盖范围增加约4。我们将升级乳房检查床，以改善我们对组织边界的定义，并提高我们对胸壁附近乳房组织的敏感性。我们将以多种方式升级我们的软件，但最重要的是减少边界附近的伪影。我们将继续对正常受试者和肿瘤患者进行试点研究，这次将获得来自放射科医生和病理学家的更具体的支持信息，最后，我们将有一个独特的机会来跟踪一组接受新辅助化疗的患者。如果成功，这些强大的新改进将提高乳腺图像的保真度，设备生成的解剖和功能信息将提高我们检测和指定乳腺肿瘤性质的能力。