Spatial and Temporal Control of Targeted Limb Movements

目标肢体运动的空间和时间控制

• 批准号: 7077811
• 负责人: Paul Cordo
• 金额: $ 31.74万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7077811
• 关键词: adult human (21+); biomechanics; electromyography; human subject; joints; limb movement; mechanical stress; mechanoreceptors; motor neurons; muscle contraction; muscle function; muscle stress; neural information processing; perception; proprioception /kinesthesia; psychomotor function; psychophysics; striated muscles; tendons

The long-range goal of this project is to determine how the human central nervous system (CNS) coordinates voluntary movement and ultimately to use this information to develop treatments for motor disorders, such as stroke. The goal of the research proposed in this application is to determine how proprioception at the receptor level-in this case, the muscle spindle-leads to perception. The central hypothesis to be investigated is that, in active movement, the primary source of proprioceptive input is muscle spindles in the lengthening, "antagonist" muscles, rather than muscle spindles in the contracting, "agonist" muscles. Three specific aims are addressed: Specific Aim 1 is to contrast the information signaled by agonist and antagonist muscle spindles to determine which of these populations provides the CNS with the most accurate information about limb position and movement. Unlike agonist muscle spindles, little is known about how antagonist muscle spindles respond to active joint rotation. We will characterize how agonist and antagonist muscle spindles signal joint position and movement to test the hypothesis that the CNS uses the input from both populations, but that the information provided by antagonist muscle spindles is the most accurate. Specific Aim 2 is to investigate how antagonist muscle spindles encode position and movement variables, to inform the CNS of the location and movement of the limbs in space. The proposed experiments are designed to test the hypothesis that, during a movement, antagonist muscle spindles signal the CNS information about the starting position, movement velocity, and limb position during movement by three distinctive features within the firing pattern. Specific Aim 3 is to characterize the influence of fusimotor input on antagonist muscle spindles. Past research on agonist muscle spindles has failed to explain why the CNS activates the fusimotor system during voluntary movement. The proposed experiments are designed to test the hypothesis that fusimotor input increases the precision with which antagonist muscle spindles signal limb position and movement during precise movements and during motor learning, but that fusimotor input does not decrease the precision of signaling from antagonist muscle spindles during loaded movements.

该项目的长期目标是确定人类中枢神经系统（CNS）如何协调随意运动，并最终利用这些信息开发针对运动障碍（例如中风）的治疗方法。 本申请中提出的研究目标是确定受体水平（在本例中为肌梭）的本体感觉如何导致感知。 要研究的中心假设是，在主动运动中，本体感觉输入的主要来源是伸长的“拮抗”肌肉中的肌梭，而不是收缩的“主动”肌肉中的肌梭。 解决了三个具体目标： 具体目标 1 是对比主动肌梭和拮抗肌梭发出的信息，以确定这些群体中的哪一个向 CNS 提供有关肢体位置和运动的最准确信息。 与主动肌梭不同，我们对拮抗肌梭如何响应主动关节旋转知之甚少。 我们将描述主动肌梭和拮抗肌梭如何发出关节位置和运动信号，以检验中枢神经系统使用来自两个群体的输入的假设，但拮抗肌梭提供的信息是最准确的。具体目标 2 是研究拮抗肌梭如何编码位置和运动变量，以告知中枢神经系统四肢在空间中的位置和运动。 所提出的实验旨在测试以下假设：在运动过程中，拮抗肌梭通过发射模式中的三个独特特征向中枢神经系统发出有关运动过程中起始位置、运动速度和肢体位置的信号。具体目标 3 是表征梭运动输入对拮抗肌梭的影响。 过去对主动肌梭的研究未能解释为什么中枢神经系统在随意运动过程中激活梭运动系统。 所提出的实验旨在检验以下假设：梭运动输入提高了精确运动和运动学习期间拮抗肌梭发出肢体位置和运动信号的精度，但梭运动输入不会降低负载运动期间拮抗肌梭发出信号的精度。

项目成果

Representation of wrist joint kinematics by the ensemble of muscle spindles from synergistic muscles.

通过协同肌肉的肌梭集合来表示腕关节运动学。

• DOI: 10.1152/jn.1998.79.5.2265
• 发表时间: 1998
• 期刊: Journal of neurophysiology.
• 作者: Verschueren,SM;Cordo,PJ;Swinnen,SP
• 通讯作者: Swinnen,SP

Proprioceptive control of multijoint movement: unimanual circle drawing.

多关节运动的本体感觉控制：单手画圆。

• DOI: 10.1007/s002210050787
• 发表时间: 1999
• 期刊: Experimental brain research
• 影响因子: 2
• 作者: Verschueren,SM;Swinnen,SP;Cordo,PJ;Dounskaia,NV
• 通讯作者: Dounskaia,NV

Proprioceptive control of multijoint movement: bimanual circle drawing.

多关节运动的本体感觉控制：双手画圆。

• DOI: 10.1007/s002210050788
• 发表时间: 1999
• 期刊: Experimental brain research
• 影响因子: 2
• 作者: Verschueren,SM;Swinnen,SP;Cordo,PJ;Dounskaia,NV
• 通讯作者: Dounskaia,NV

Kinesthetic and visual control of a bimanual task: specification of direction and amplitude.

双手任务的动觉和视觉控制：方向和幅度的规范。

• DOI: 10.1523/jneurosci.09-02-00447.1989
• 发表时间: 1989
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Flanders,M;Cordo,PJ
• 通讯作者: Cordo,PJ