Complement Activation and Pregnancy Loss

补体激活和妊娠失败

• 批准号: 7142031
• 负责人: ANNE M. LYNCH
• 金额: $ 11.94万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-12 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7142031
• 关键词: biomarker; clinical research; complement pathway regulation; enzyme linked immunosorbent assay; human subject; immunological substance; patient oriented research; pregnancy loss; prognosis; women' s health

DESCRIPTION (provided by applicant): Anne Lynch MD, MSPH is an Assistant Professor in the Department of Obstetrics and Gynecology at the University of Colorado at Denver and Health Sciences Center (UCDHSC). Dr Lynch has an established commitment to clinical research. This Mentored Patient-Oriented Research Career Development Award will facilitate the development of Dr. Lynch into a successful independent investigator in patient-oriented research. The proposed training under the mentorship of Michael Holers MD (Immunology) Tim Byers MD, MPH (Epidemiology) and other advisors is designed to increase her skills in the area of perinatal epidmiology and immunology. This award will allow Dr. Lynch to pursue higher level epidemiology and statistical courses from the Epidemiology PhD program at UCDHSC. Classes from the UCDHSC Integrated Department of Immunology Graduate program are also included in the coursework. The objective of her research project is to study the contribution of split products from complement activation to pregnancy loss in a cohort of 1000 women. Recent studies in experimental murine models suggest that complement activation is the final effector mechanism for immunologically-mediated pregnancy loss. The proposal will translate these observations to a human study in the setting of the award. A sample for split products will be obtained from all women in the cohort in early pregnancy (<15 weeks gestation) along with a detailed clinical history. At the conclusion of the study, women with pregnancy loss will be identified from the incident cohort. The plasma samples for these women will be assayed along with those of a randomly selected comparison group of women without pregnancy loss. The levels of split products in cases will be compared to the levels in the controls. A follow-up sample will be obtained on women who suffer a loss, to evaluate for change in levels from baseline. James Muphy PhD at National Jewish Medical and Research Center will guide the univariate and multivariable logistic regression analysis of the study. This project, the mentors, the enthusiastic support from the Dept. of OB/GYN and the research resources available at UCDHSC will provide Dr Lynch with an excellent environment for her career development. The proposed study will provide unique information on the role of complement activation split products among women with pregnancy loss, and may ultimately lead to preventive treatment for this tragic outcome.

简介（由申请人提供）：Anne Lynch MD， MSPH是科罗拉多大学丹佛分校和健康科学中心（UCDHSC）妇产科助理教授。林奇博士一直致力于临床研究。该指导以患者为导向的研究职业发展奖将促进Lynch博士在以患者为导向的研究中成为一名成功的独立研究者。在Michael Holers医学博士（免疫学）、Tim Byers医学博士（流行病学）和其他顾问的指导下，拟议的培训旨在提高她在围产期流行病学和免疫学领域的技能。该奖项将允许Lynch博士从UCDHSC的流行病学博士项目中攻读更高水平的流行病学和统计课程。UCDHSC综合免疫学研究生课程的课程也包括在课程作业中。她的研究项目的目的是在1000名妇女的队列中研究分裂产品从补体激活到妊娠损失的贡献。最近在实验小鼠模型中的研究表明，补体激活是免疫介导的妊娠丢失的最终效应机制。该提案将把这些观察结果转化为奖项设定的人类研究。将从该队列中所有妊娠早期（<15周妊娠）的妇女以及详细的临床病史中获取分离产品样本。在研究结束时，将从事件队列中确定怀孕失败的妇女。这些妇女的血浆样本将与随机选择的一组没有妊娠损失的妇女的血浆样本一起进行分析。病例中分离产品的水平将与对照中的水平进行比较。将对遭受损失的妇女进行后续抽样，以评估基线水平的变化。国家犹太医学和研究中心的James Muphy博士将指导该研究的单变量和多变量逻辑回归分析。这个项目、导师、妇产科的热情支持以及UCDHSC的研究资源将为Lynch博士的职业发展提供一个良好的环境。拟议的研究将提供补体激活分裂产品在妊娠流产妇女中的作用的独特信息，并可能最终导致对这一悲惨结局的预防性治疗。