OUTCOMES IN SPONTANEOUS & LATROGENIC MULTIPLE PREGNANCY

自发的结果

• 批准号: 6135444
• 负责人: ANNE M. LYNCH
• 金额: $ 6.2万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6135444
• 关键词: assistive reproductive technique; case history; clinical research; disease /disorder proneness /risk; female; fertility; health care service utilization; health science research analysis /evaluation; health services research tag; human subject; outcomes research; pregnancy; twin /multiplet; women's health

The use of assisted reproductive technology is believed to be one cause of the rising incidence of multi-fetal gestations. These multiple births more often result in preterm delivery, low birthweight, and associated neonatal morbidity and mortality. The study will address the following specific aims; 1) describe the factors in the mother's infertility that led to the need for assisted reproduction; 2) report the specific methods that led to the pregnancy; 3) compare the maternal risk factors, prenatal and intrapartum events, maternal, neonatal and post-natal outcomes (up to one year of age) and health care utilization for multiple pregnancies conceived through assisted technology with those conceived spontaneously. The study design is a retrospective cohort study. Mothers with multiple gestations will be drawn from a large database of Kaiser Permanente patients who delivered after 20 weeks gestation between January 1994 and December 1999. Exposed patients (called "cases" in the proposal) are women who conceive as a result of assisted reproduction (ovulation induction and IVF). Non-exposed patients (called "controls" in the study) are defined as multiple gestations conceived spontaneously. Data will be extracted from numerous administrative databases, prenatal records, infant records, and chart reviews. Numerous maternal and neonatal outcomes will be evaluated to determine if multiple pregnancies conceived with assisted reproduction are at higher risk for adverse outcomes when compared to pregnancies conceived spontaneously.

辅助生殖技术的使用被认为是 多胎妊娠发病率上升的原因之一。 这些多 出生更经常导致早产，低出生体重，以及相关的 新生儿发病率和死亡率。 该研究将解决以下问题 具体目标; 1）描述导致母亲不孕的因素 辅助生殖的需要; 2）报告导致 比较孕妇产前和产时的危险因素 事件、孕产妇、新生儿和产后结局（1岁以下），以及 多胎妊娠的保健利用情况 技术与那些自发构思的。 研究设计为回顾性队列研究。 母亲有多个 妊娠将从凯撒医疗机构的大型患者数据库中抽取 在1994年1月至1999年12月期间怀孕20周后分娩。 暴露的患者（在提案中称为“病例”）是怀孕的女性， 辅助生殖（排卵诱导和IVF）的结果。 非暴露 患者（在研究中称为“对照组”）被定义为多胎妊娠 自然受孕 数据将从众多的行政部门中提取 数据库、产前记录、婴儿记录和病历审查。 许多 将评估产妇和新生儿的结局，以确定是否有多个 辅助生殖怀孕的风险更高， 与自然受孕相比，不良结局。

项目成果

The contribution of assisted conception, chorionicity and other risk factors to very low birthweight in a twin cohort

• DOI: 10.1046/j.1471-0528.2003.02342.x
• 发表时间: 2003-04
• 期刊: BJOG: An International Journal of Obstetrics & Gynaecology
• 作者: Anne M. Lynch;R. Mcduffie;Janet Stephens;James R. Murphy;K. Faber;M. Orleans

Perinatal loss among twins.

双胞胎围产期损失。

• DOI: 10.7812/tpp/05-101
• 发表时间: 2007
• 期刊: The Permanente journal
• 作者: Lynch,Anne;McDuffieJr,Robert;Lyons,Ella;Chase,Mary;Orleans,Miriam
• 通讯作者: Orleans,Miriam