Complement Activation and Pregnancy Loss

补体激活和妊娠失败

• 批准号: 7676198
• 负责人: ANNE M. LYNCH
• 金额: $ 13.1万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-12 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7676198
• 关键词: Animals; Area; Award; Biological Assay; Classical Complement Pathway; Clinical; Clinical Research; Colorado; Complement; Complement 3 Convertase; Complement Activation; Conceptus; DBA/2 Mouse; Deposition; Development; Discipline of obstetrics; Doctor of Philosophy; Environment; Epidemiology; Fetal Resorption; Frequencies; Gynecology; Habitual Abortion; Health Sciences; Human; Immune; Immunoglobulin G; Immunology; Inflammatory Response; Lead; Logistic Regressions; Mediating; Medical Research; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Modeling; Mus; Natural History; Neutrophil Infiltration; Outcome; Perinatal; Placenta; Plasma; Pregnancy; Pregnancy Complications; Pregnancy loss; Pregnant Women; Preventive; Recording of previous events; Regression Analysis; Research; Research Personnel; Research Project Grants; Resources; Role; Sampling; Study models; Thrombosis; Time; Training; Translating; Universities; Visit; Woman; abortion; career development; cohort; comparison group; design; fetal; follow-up; follower of religion Jewish; human study; in utero; inhibitor/antagonist; mouse crry protein; mouse model; patient oriented research; pregnant; prevent; professor; programs; skills

DESCRIPTION (provided by applicant): Anne Lynch MD, MSPH is an Assistant Professor in the Department of Obstetrics and Gynecology at the University of Colorado at Denver and Health Sciences Center (UCDHSC). Dr Lynch has an established commitment to clinical research. This Mentored Patient-Oriented Research Career Development Award will facilitate the development of Dr. Lynch into a successful independent investigator in patient-oriented research. The proposed training under the mentorship of Michael Holers MD (Immunology) Tim Byers MD, MPH (Epidemiology) and other advisors is designed to increase her skills in the area of perinatal epidmiology and immunology. This award will allow Dr. Lynch to pursue higher level epidemiology and statistical courses from the Epidemiology PhD program at UCDHSC. Classes from the UCDHSC Integrated Department of Immunology Graduate program are also included in the coursework. The objective of her research project is to study the contribution of split products from complement activation to pregnancy loss in a cohort of 1000 women. Recent studies in experimental murine models suggest that complement activation is the final effector mechanism for immunologically-mediated pregnancy loss. The proposal will translate these observations to a human study in the setting of the award. A sample for split products will be obtained from all women in the cohort in early pregnancy (<15 weeks gestation) along with a detailed clinical history. At the conclusion of the study, women with pregnancy loss will be identified from the incident cohort. The plasma samples for these women will be assayed along with those of a randomly selected comparison group of women without pregnancy loss. The levels of split products in cases will be compared to the levels in the controls. A follow-up sample will be obtained on women who suffer a loss, to evaluate for change in levels from baseline. James Muphy PhD at National Jewish Medical and Research Center will guide the univariate and multivariable logistic regression analysis of the study. This project, the mentors, the enthusiastic support from the Dept. of OB/GYN and the research resources available at UCDHSC will provide Dr Lynch with an excellent environment for her career development. The proposed study will provide unique information on the role of complement activation split products among women with pregnancy loss, and may ultimately lead to preventive treatment for this tragic outcome.

描述（由申请人提供）：Anne Lynch医学博士，MSPH是丹佛科罗拉多大学和健康科学中心（UCDHSC）妇产科系的助理教授。林奇博士对临床研究有着既定的承诺。这个指导以病人为导向的研究职业发展奖将促进林奇博士发展成为一个成功的独立研究者在以病人为导向的研究。在Michael Holers医学博士（免疫学）Tim Byers医学博士，MPH（流行病学）和其他顾问的指导下，拟议的培训旨在提高她在围产期生殖学和免疫学领域的技能。Lynch博士将从UCDHSC的流行病学博士课程中获得更高水平的流行病学和统计课程。从免疫学研究生课程的UCDHSC综合系类也包括在课程中。她的研究项目的目的是研究1000名妇女的队列中补体激活分裂产物对妊娠丢失的贡献。最近在实验鼠模型中的研究表明，补体激活是免疫介导的妊娠丢失的最终效应机制。该提案将把这些观察转化为奖项设置中的人类研究。将从妊娠早期（妊娠<15周）的队列中的所有女性中获得分裂产物的样品沿着详细的临床病史。研究结束时，将从事件队列中识别妊娠丢失的女性。将沿着分析这些女性的血浆样本以及随机选择的无妊娠丢失女性对照组的血浆样本。将病例中裂解产物的水平与对照品中的水平进行比较。将从遭受损失的妇女中获得随访样本，以评估水平相对于基线的变化。国家犹太医学和研究中心的James Muphy博士将指导本研究的单变量和多变量逻辑回归分析。这个项目，导师们，部门的热情支持。妇产科医生和UCDHSC的研究资源将为Lynch博士的职业发展提供良好的环境。这项拟议的研究将提供关于补体激活分裂产物在妊娠丢失妇女中作用的独特信息，并可能最终导致对这种悲惨结局的预防性治疗。