Graphene and graphene-related materials for tissue engineering

用于组织工程的石墨烯和石墨烯相关材料

• 批准号: 2669143
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2669143
• 关键词: Graphene; graphene; related; materials; tissue

Graphene and graphene-related materials for tissue engineeringTissue engineering is an interdisciplinary field that strives to develop biological substitutes to restore, improve or enhance the function of damaged tissues or whole organs. Developing novel suitable scaffolds to fabricate functional tissue constructs is crucial in tissue engineering. Gelatine is a cheap biomolecule derived from collagen with excellent biocompatibility and thus often used in cell and tissue cultures to replace collage for biomaterial purposes. However, the mechanical properties of gelatine is poor for tissue engineering applications. Graphene and graphene-related materials have attracted huge attention in recent years due to their outstanding properties and a wide range of potential applications. Graphene oxide (GO) and rGO are major chemical derivatives of graphene, has great potential in biomedical applications such as drug delivery, tissue engineering, bioimaging and biosensors. The presence of various functional groups like carboxylic (COOH) and hydroxyl (OH) allows GO (and rGO) to be functionalised, conjugated or immobilised with other molecules or biomaterials. We have recently developed a new method to synthesise high quality monolayer GO at various controllable size. This PhD project will investigate how the addition of GO affects the biocompatibility and physicochemical properties of biomaterials to be used for tissue engineering. During this project, the student will study how addition of different sized GO affects the mechanical and biological properties of biomaterials such as gelatine and gelatine derivatives. The key objectives including: (1) Cytotoxicity analyses of different sized GO by coupled use of cell culture and various biochemical assays. (2) Cytotoxicity analyses of various GO-biomaterials composites with different amount of GO. (3) Physicochemical and mechanical characterisations of selected GO-biomaterials composites. (4) Explore potential application of selected GO-biomaterials composites in tissue engineering. This multidisciplinary project provides an excellent opportunity for the student to broaden knowledge and develop his/her research skills in material, engineering, and biological sciences.

石墨烯和石墨烯相关材料用于组织工程组织工程是一个跨学科的领域，致力于开发生物替代品，以恢复，改善或增强受损组织或整个器官的功能。开发新的合适的支架来构建功能性组织构建体是组织工程的关键。明胶是一种来源于胶原蛋白的廉价生物分子，具有优异的生物相容性，因此经常用于细胞和组织培养以代替胶原蛋白用于生物材料目的。然而，明胶的机械性能对于组织工程应用是差的。石墨烯及其相关材料由于其优异的性能和广泛的潜在应用，近年来引起了人们的极大关注。氧化石墨烯（GO）和rGO是石墨烯的主要化学衍生物，在药物输送、组织工程、生物成像和生物传感器等生物医学领域具有巨大的应用潜力。各种官能团如羧基（COOH）和羟基（OH）的存在允许GO（和rGO）与其他分子或生物材料官能化、缀合或固定化。我们最近开发了一种新的方法来合成各种可控尺寸的高质量单层GO。本博士项目将研究GO的加入如何影响用于组织工程的生物材料的生物相容性和物理化学性质。在这个项目中，学生将研究添加不同大小的GO如何影响生物材料（如明胶和明胶衍生物）的机械和生物特性。主要目的包括：（1）通过细胞培养和各种生化测定的结合使用，分析不同大小的GO的细胞毒性。(2)具有不同量GO的各种GO-生物材料复合物的细胞毒性分析。(3)所选GO-生物材料复合材料的物理化学和机械特性。(4)探索所选GO-生物材料复合材料在组织工程中的潜在应用。这个多学科项目为学生提供了一个极好的机会，以扩大知识和发展他/她在材料，工程和生物科学的研究技能。