Carbon Nanotube Nanoelectrode Array/Deep Brain Stimul.

碳纳米管纳米电极阵列/深部脑刺激。

• 批准号: 7016332
• 负责人: JUN LI
• 金额: $ 11.26万
• 依托单位: NASA--AMES RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-15 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7016332
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; biosensor device; brain electronic stimulator; brain imaging /visualization /scanning; brain mapping; electrochemistry; laboratory rat; microelectrodes; miniature biomedical equipment; monitoring device; nanomedicine; nanotechnology; neurochemistry; tissue /cell culture

DESCRIPTION (provided by applicant): Many common disorders of the nervous system are potentially treatable using techniques that employ precise, controlled electrical recording (for localization) and/or precise, controlled electrical stimulation (for modulation). An example is deep brain stimulation (DBS) for movement disorders (e.g. Parkinson's disease, which affects 1 million Americans). DBS is currently in clinical trials for conditions such as intractable epilepsy, depression, and eating disorders. Precise localization within the brain will also be essential for implantation of stem cells and other forms of transplantation when such methods reach clinical usefulness. Nanoelectrodes offer the possibility of improving significantly our ability (1) to localize specific regions (subnuclei) of the brain, with the benefit of permanent implantation (which is not feasible in clinical situations with current microelectrodes), (2) to stimulate specific regions (subnuclei) of the brain much more precisely than is possible with current macroelectrodes, and (3) to monitor or record the local environments (neurotransmitter levels, e.g. dopamine and glutamate) with nanomolar sensitivity and millisecond temporal resolution yet with minimum disturbance using in situ electrochemical methods based on nanoelectrode arrays. The long-term goal is to establish a permanently-implanted closed-loop system where the monitoring of neurotransmitter levels and local brain electrical activity guides the local brain stimulation (neuromodulation). The proposed work involves the development of nanoelectrode arrays specifically for precise, permanently implanted, local brain recording of electrical activity and neurotransmitter levels as well as stimulation. Following additional refinement and laboratory testing of 200 #m nanoelectrode arrays already developed, the porposed research utilizes cell cultures, brain tissue slices, and a standard small animal model of Parkinson's disease to test the prototype nanoelectrode arrays. This research plan extends and integrates the work done to date by the Nanotechnology and Smart Systems groups at NASA Ames Research Center: (1) nanoelectrode fabrication and application to the development of ultrasensitive biosensors, and (2) real-time tissue recognition using multiple microsensors and neural networks to determine a unique "signature" for both tissues (normal and abnormal) and regions (subnuclei) of the brain.

描述（由申请人提供）：使用精确的，受控的电记录（用于定位）和/或精确的，受控的电刺激（用于调制）的技术，可以使用神经系统的许多常见疾病来治疗。一个例子是针对运动障碍（例如帕金森氏病，影响100万美国人）的大脑刺激（DBS）。目前，DBS正在接受诸如顽固性癫痫，抑郁和饮食失调等疾病的临床试验。当这种方法达到临床实用性时，大脑中的精确定位对于干细胞和其他形式的移植也将是必不可少的。 纳米电极提供了显着提高我们（1）将特定区域（亚核）定位的能力，并具有永久性植入的好处（在具有当前微电极的临床情况下这是不可行的（2），（2）刺激当前的特定区域（2），而不是当前的特定区域（比较），而不是当前的特定区域（3）或可能（subnuclei and）。局部环境（神经递质水平，例如多巴胺和谷氨酸）具有纳摩敏感性和毫秒的时间分辨率，但使用基于纳米电极阵列的原位电化学方法具有最小干扰。长期的目标是建立一个永久性植入的闭环系统，其中神经递质水平和局部脑电活动的监测指导局部脑刺激（神经调节）。 提出的工作涉及纳米电极阵列的开发，专门用于精确，永久植入电活动的局部大脑记录电活动和神经递质水平以及刺激。在开发了200 #m纳米电极阵列的其他改进和实验室测试之后，孔孔研究利用细胞培养物，脑组织切片和标准的帕金森氏病小动物模型来测试原型纳米电极阵列。 This research plan extends and integrates the work done to date by the Nanotechnology and Smart Systems groups at NASA Ames Research Center: (1) nanoelectrode fabrication and application to the development of ultrasensitive biosensors, and (2) real-time tissue recognition using multiple microsensors and neural networks to determine a unique "signature" for both tissues (normal and abnormal) and regions (subnuclei) of the brain.