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DYNAMIC BINDING OF PKA REGULATORY SUBUNIT RI ALPHA

DYNAMIC BINDING OF PKA REGULATORY SUBUNIT RI ALPHA
PKA 调节亚基 RI ALPHA 的动态结合
批准号：
7601720
负责人：
SUSAN S. TAYLOR
金额：
$0.18万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
项目状态：
已结题
起止时间：
2007-05-01 至 2008-04-30
来源：
https://reporter.nih.gov/project-details/7601720
关键词：
BindingCatalytic DomainComplexComputer Retrieval of Information on Scientific Projects DatabaseFundingGrantInstitutionPliabilityResearchResearch PersonnelResourcesSourceStructureUnited States National Institutes of Healthcyclic-AMP-dependent protein kinase regulatory subunit RIalphamolecular dynamics

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中文摘要
翻译
这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 最近的晶体结构表明，PKA的调节亚基RIpha在与催化亚基形成络合物时发生了戏剧性的构象变化。分子动力学研究是为了阐明固有的构象柔性和与催化亚基的相互作用在络合物的形成和稳定中所起的作用。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent crystal structures have revealed that regulatory subunit RIalpha of PKA undergoes a dramatic conformational change upon complex formation with the catalytic subunit. Molecular dynamics studies were initiated to elucidate the contributions of intrinsic conformational flexibility and interactions with the catalytic subunit in formation and stabilization of the complex.
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会议论文
Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches
Illuminating the Role of understudied PRKACB Splice Variants in PKA Signaling
Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches
Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches
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