Time course of learning perceptual pop-out in V1 and V2

V1和V2中学习感知弹出的时间过程

• 批准号: 7123335
• 负责人: MATTHEW A SMITH
• 金额: $ 5.04万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123335
• 关键词: Macaca mulatta; cerebral cortex; learning; neural plasticity; postdoctoral investigator; psychometrics; psychophysiology; sensory mechanism; visual cortex; visual perception; visual stimulus

DESCRIPTION (provided by applicant): This project focuses on the neural basis of perceptual learning in visual cortex. Although plasticity has been well documented in visual cortex, the time course of plasticity and the kinds of changes that occur in visual neurons have not been fully characterized. The proposed experiments aim to explore the development and nature of visual plasticity due to extensive training by monitoring the evolution of cortical neuronal responses relative to the time course of behavioral change. The change of psychometric and neurometric contrast response functions and the change in correlation within neuronal ensembles will be explored as more sensitive measures of plasticity. An understanding of the mechanisms of change in the cerebral cortex as a result of training is potentially very important for the medical treatment of humans with various kinds of brain damage. In particular, the treatment of strokes and other focal brain lesions can gain insight from the research in this proposal. In addition, knowledge of the limits of visual cortical plasticity are important in understanding diseases such as amblyopia, in which there are known changes in the cortex as a result of a visual impairment.

描述（由申请人提供）：该项目重点研究视觉皮层感知学习的神经基础。尽管视觉皮层的可塑性已得到充分记录，但可塑性的时间过程和视觉神经元中发生的变化类型尚未得到充分表征。拟议的实验旨在通过监测皮质神经元反应相对于行为变化时间过程的演变来探索由于广泛训练而导致的视觉可塑性的发展和本质。心理测量学和神经测量学对比反应函数的变化以及神经元集合内相关性的变化将作为更灵敏的可塑性测量进行探索。了解训练引起的大脑皮层变化机制对于治疗患有各种脑损伤的人类来说可能非常重要。特别是，中风和其他局灶性脑损伤的治疗可以从本提案的研究中获得见解。此外，了解视觉皮层可塑性的局限性对于理解弱视等疾病很重要，弱视是由于视觉障碍导致皮层发生已知的变化。

项目成果

Stimulus selectivity and spatial coherence of gamma components of the local field potential.

• DOI: 10.1523/jneurosci.0645-11.2011
• 发表时间: 2011-06-22
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Jia X;Smith MA;Kohn A
• 通讯作者: Kohn A