RESpiratory monitoring reduCing drUg harm, the RESCU project

苏格兰是所有欧洲国家中与毒品有关的人均死亡人数最多的国家(《苏格兰国家记录》，2021年)。苏格兰的大多数DRD是由于阿片类药物引起的呼吸抑制(OIRD)(信息服务司ISD-NHS国家服务苏格兰，2018年)。OIRD是由阿片类药物降低脑干对二氧化碳升高的敏感度引起的，二氧化碳升高可能导致快速呼吸衰竭。纳洛酮在逆转过量用药方面有效；然而，它的使用需要旁观者的在场。泰赛德62.9%的DRD发生在个人单独使用药物时(泰赛德药物死亡审查小组，2019年)。因此，仅预防吸毒者服用过量药物(PWUD)就是一项未得到满足的需求。该项目是一项正在进行的混合方法观察队列研究，旨在调查安装在胸部的加速度计传感器是否能够准确和可靠地捕获PWUD的呼吸模式，以确定过量服药期间紧急反应的触发点。这项研究的目的是评估该设备对PWUD和来自第三部门支助小组的第一响应者利益相关者群体和第一响应者的接受度，以创建干预途径。计划研究时间为12个月，从2022年1月到2023年1月。

Scotland has the highest number of drug related deaths (DRDs) per capita out of any European country (National Records of Scotland, 2021). The majority of DRDs in Scotland occur due to opioid induced respiratory depression (OIRD) (Information Services Division ISD - NHS National Services Scotland, 2018). OIRD is caused by opioid drugs decreasing the sensitivity of the brain stem to rises in CO2, which can lead to rapid respiratory failure. Naloxone is effective at overdose reversal; however, its administration requires bystander presence. 62.9% DRDs in Tayside occurred when individuals used substances alone (Tayside Drug Death Review Group, 2019). Preventing overdoses in people who use drugs (PWUD) alone is therefore an unmet need. This project is an ongoing mixed-methods observational cohort study aiming to investigate whether an accelerometer sensor attached to the chest can accurately and reliably capture respiratory patterns of PWUD to determine trigger points for an emergency response during an overdose. The study aims to assess the acceptability of the device to PWUD and first responder stakeholder groups from the third sector support groups and first responders to create an intervention pathway. The planned study duration is 12 months, from January 2022 to January 2023.