The neural response to sleep loss in the elderly

老年人对睡眠不足的神经反应

• 批准号: 7128176
• 负责人: BRYCE A. MANDER
• 金额: $ 3.21万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2008-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7128176
• 关键词: aging; attention; clinical research; functional magnetic resonance imaging; human subject; neuroregulation; parietal lobe /cortex; predoctoral investigator; sleep deprivation; space perception; thalamus; visual perception

DESCRIPTION (provided by applicant): In the proposed study, our primary goal is to determine if older adults, as compared to younger adults, will be less able to recruit neural areas necessary for compensation during sleep deprivation on an attention task and a task of response inhibition. Tasks of visual spatial attention and response inhibition will be used, because they assess the functioning of two distinct networks particularly vulnerable to sleep loss. We specifically propose to use functional magnetic resonance imaging (fMRI) to investigate the effects of 36 hours of sleep deprivation on the neural response to both a visual spatial attention task and a task of response inhibition. Functional magnetic resonance imaging (fMRI) will be used to measure blood flow changes via the blood oxygen level dependent (BOLD) method. This method allows for the high spatial and temporal resolution necessary for these proposed investigations. Influence of age and task type will be examined to determine how sleep loss interacts with each of these factors to produce altered neural function and impaired performance.

描述（由申请人提供）：在拟议的研究中，我们的主要目标是确定老年人与年轻人相比，在注意力任务和反应抑制任务的睡眠剥夺期间，是否不太能够招募必要的神经区域进行补偿。视觉空间注意和反应抑制的任务将被使用，因为它们评估了两个不同网络的功能，特别容易受到睡眠不足的影响。我们特别建议使用功能性磁共振成像（fMRI）研究36小时的睡眠剥夺对视觉空间注意任务和反应抑制任务的神经反应的影响。将使用功能性磁共振成像（fMRI）通过血氧水平依赖（BOLD）方法测量血流变化。这种方法允许这些拟议的调查所需的高空间和时间分辨率。年龄和任务类型的影响将被检查，以确定睡眠不足如何与这些因素中的每一个相互作用，以产生改变的神经功能和受损的性能。