Core Center for Clinical Research at Northwestern University

西北大学临床研究核心中心

• 批准号: 10708051
• 负责人: Leena Sharma
• 金额: $ 78.64万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-19 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708051
• 关键词: Abbreviations; Acceleration; Accelerometer; Area; Attention; Behavioral; Behavioral Sciences; Bioinformatics; Budgets; Clinical; Clinical Informatics; Clinical Research; Collaborations; Communication; Communities; Community Outreach; Consult; Data; Database Management Systems; Databases; Development; Disease; Educational Activities; Ensure; Environment; Epidemiology; Equity; Evaluation; Feedback; Fostering; Foundations; Funding; Genomics; Goals; Grant; Health; Individual; Infrastructure; Institution; Intervention; Knowledge; Lead; Leadership; Life; Life Style; Manuscripts; Medical; Mental Health; Methodology; Mission; Motor; Musculoskeletal; Neighborhoods; Nutritional Science; Operations Research; Outcome; Outcome Assessment; Outcome Measure; Pathway interactions; Patient Self-Report; Performance; Persons; Physical activity; Physical assessment; Physiological; Policy Analysis; Positioning Attribute; Prevention; Prevention strategy; Procedures; Productivity; Recommendation; Registries; Rehabilitation therapy; Research; Research Design; Research Personnel; Resource Sharing; Resources; Risk; Science; Scientist; Sensory; Sleep; Specialist; Statistical Data Interpretation; Structure; Symptoms; Technology; Training; Universities; Vision; Work; clinical center; clinical development; cognitive function; cohort; community engaged research; community engagement; cost effectiveness; data management; data sharing; data streams; design; economic evaluation; education research; empowerment; experience; handheld mobile device; health equity; improved; innovation; member; operation; performance based measurement; person centered; personalized approach; portability; pragmatic study; preventive intervention; programs; prospective; psychologic; satisfaction; sedentary lifestyle; sensor; social; social health determinants; synergism; technological innovation; therapy development; wearable sensor technology; web based interface

The overarching goal of the Northwestern University (NU) CCCR is to promote cutting-edge clinical research aimed at prevention or control of rheumatic and musculoskeletal conditions and poor outcomes associated with them. While we will provide broad support, we will particularly seek to drive this theme: prevention strategy and intervention development through lifestyle, behavioral, medical, and rehabilitative solutions, built on a foundation of person-centered assessment in daily life and community engagement. Our overall aims are to: 1) accelerate and enhance funded research, by increasing stakeholder engagement, efficiency, rigor, collaboration, cost-effectiveness, productivity, and impact; 2) organize and catalyze all relevant research at NU, applying a health equity lens, adding value, and moving it forward in a way that would otherwise not be feasible; 3) promote new research within our mission areas, by expanding the Research Community working in these areas and by expanding research fields within the mission. We will organize our resources into Cores but function as an integrated unit. Methodologic Core aims are: 1) provide expertise in study design, methodology, outcomes, and analysis planning; work with the Community Advisory Board and Resource Core to assist design that incorporates personal and community perspectives; integrate, as needed, input on adaptive and pragmatic study design, epidemiology, behavioral science, nutritional science, economic evaluation, policy analysis, genomics, bioinformatics, and clinical informatics; 2) facilitate use of existing databases and registries; 3) promote safe and responsible data management; 4) assist users in statistical analyses that maximize the potential of study data; and 5) enhance the training environment. Resource Core, Community Engaged Assessment and Intervention Science and Technology in Daily Life, aims are: 1) create and sustain interaction between stakeholders and research teams through project stages: a) build pathways for community?academic exchange to increase research value for improving health and equity by refining ideas and planning in partnership; b) build capacity for community-engaged research; 2) help teams design research that integrates personal and community perspectives; refine research questions, study design, assessment plan, intervention comparators and intervention procedures, and assist with budget planning, with the Methodologic Core; get stakeholder input on variables and outcomes and collaboratively develop assessment plans that can include: social determinants of health; accelerometry to assess physical activity, sedentary behavior, and sleep; mobile and sensor-based applications that identify behavioral markers; and wearable biosensors to predict physiological and psychological states; 3) help teams operationalize their research and create dissemination plans. Because our CCCR is centered on the goal to improve how persons feel and function in daily life, focuses on community and personal experience, and builds upon the wearable and portable technology revolution, we are positioned to have substantial impact on work within and beyond NU.

西北大学（NU）CCCR的总体目标是促进尖端临床研究 旨在预防或控制风湿性和肌肉骨骼疾病以及与 他们在提供广泛支持的同时，我们将特别努力推动这一主题：预防战略和 通过生活方式、行为、医疗和康复解决方案进行干预开发，建立在 在日常生活和社区参与中建立以人为本的评估基础。我们的总体目标是： 1)通过提高利益相关者的参与度、效率、严谨性， 协作，成本效益，生产力和影响; 2）组织和催化所有相关研究， NU，应用健康公平透镜，增加价值，并以一种否则不会被 可行; 3）通过扩大研究社区，促进我们使命领域内的新研究， 并扩大使命内的研究领域。我们将把资源组织成核心， 作为一个整体的功能。核心目标是：1）提供研究设计，方法学， 成果和分析规划;与社区咨询委员会和资源核心合作， 结合个人和社区观点的设计;根据需要， 实用研究设计，流行病学，行为科学，营养科学，经济评估，政策 分析，基因组学，生物信息学和临床信息学; 2）促进现有数据库的使用， 登记处; 3）促进安全和负责任的数据管理; 4）协助用户进行统计分析， 最大限度地发挥研究数据的潜力; 5）改善培训环境。资源核心，社区 日常生活中的评估和干预科学技术，目标是：1）创造和维持 利益攸关方和研究团队在项目各阶段的互动： 社区？学术交流，通过提炼思想，提高研究价值，改善健康和公平 和伙伴关系规划; B）建设社区参与研究的能力; 2）帮助团队设计研究 整合个人和社区观点;完善研究问题，研究设计，评估 计划、干预比较和干预程序，并协助预算规划， 方法论核心;获取利益相关者对变量和结果的投入，并协同开展评估 计划可以包括：健康的社会决定因素;评估身体活动的加速度计，久坐 行为和睡眠;识别行为标记的移动的和基于传感器的应用;以及可穿戴设备 生物传感器预测生理和心理状态; 3）帮助团队实施他们的研究， 制定传播计划。因为我们的CCCR以改善人们的感受为目标， 在日常生活中的功能，侧重于社区和个人体验，并建立在可穿戴和 便携式技术革命，我们的定位是有实质性的影响工作内外NU。

项目成果

Sensitivity to change and association of three-dimensional meniscal measures with radiographic joint space width loss in rapid clinical progression of knee osteoarthritis.

• DOI: 10.1007/s00330-017-5140-1
• 发表时间: 2018-05
• 期刊: European radiology
• 影响因子: 5.9
• 作者: Roth M;Emmanuel K;Wirth W;Kwoh CK;Hunter DJ;Eckstein F
• 通讯作者: Eckstein F

One report, multiple aims: orthopedic surgeons vary how they use patient-reported outcomes with patients.

• DOI: 10.1007/s11136-022-03251-7
• 发表时间: 2023-03
• 期刊: QUALITY OF LIFE RESEARCH
• 影响因子: 3.5
• 作者: Lavallee, Danielle C.;Rothrock, Nan E.;Chen, Antonia F.;Franklin, Patricia D.
• 通讯作者: Franklin, Patricia D.

Evaluation of structured data from electronic health records to identify clinical classification criteria attributes for systemic lupus erythematosus.

• DOI: 10.1136/lupus-2021-000488
• 发表时间: 2021-04
• 期刊: Lupus science & medicine
• 影响因子: 3.9
• 作者: Walunas TL;Ghosh AS;Pacheco JA;Mitrovic V;Wu A;Jackson KL;Schusler R;Chung A;Erickson D;Mancera-Cuevas K;Luo Y;Kho AN;Ramsey-Goldman R
• 通讯作者: Ramsey-Goldman R

Wearable Technology and Physical Activity in Chronic Disease: Opportunities and Challenges.

• DOI: 10.1016/j.amepre.2017.08.015
• 发表时间: 2018-01
• 期刊: American journal of preventive medicine
• 影响因子: 5.5
• 作者: Phillips SM;Cadmus-Bertram L;Rosenberg D;Buman MP;Lynch BM
• 通讯作者: Lynch BM

Reallocating time spent in sleep, sedentary behavior and physical activity and its association with pain: a pilot sleep study from the Osteoarthritis Initiative.

重新分配睡眠、久坐行为和体力活动的时间及其与疼痛的关系：骨关节炎倡议的一项试点睡眠研究。

• DOI: 10.1016/j.joca.2018.07.002
• 发表时间: 2018
• 期刊: Osteoarthritis and cartilage
• 影响因子: 7
• 作者: Song,J;Dunlop,DD;Semanik,PA;Chang,AH;Lee,YC;Gilbert,AL;Jackson,RD;Chang,RW;Lee,J
• 通讯作者: Lee,J