Investigating the role played by inflammationin the development of colorectal cancer

研究炎症在结直肠癌发展中的作用

• 批准号: 2740219
• 金额: --
• 依托单位: University of Leicester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2740219
• 关键词: Investigating; role; played; inflammationin; development

Your work within our multidisciplinary research team will forward our understanding the mechanisms that underline the initiation and progression of CRC. It will help developing novel preventive and therapeutic interventions. You will focus on an exciting section of cancer research that aims at dissecting the cross talk between the immune system, inflammation and CRC development. To achieve this ambitious goal, you will be trained to master a wide array of experimental paradigms, including genetically-modified mouse models, last-generation 3D organoids culture and human patient-derived explants. The latter is a novel experimental model pioneered by the University of Leicester. You will combine traditional wet-lab techniques, the backbone of experimental biology, with modern cutting-edge transcriptomic and bioinformatics analyses to decipher the impact that inflammation has on the homeostasis of intestinal epithelial cells and their ability to form tumours. Moreover, to accelerate translation of experimental data to patients, you will test the ability of anti-inflammatory drugs to restrict cancer proliferation and aggressiveness in human patient-derived explant culture. During your PhD, you will work within the Leicester University Cancer Research Centre, a forward-thinking research hub with a vibrant and enthusiastic post-graduate research community. You will have access to state-of-the-art facilities, such as a pre-clinical research facility, an explant laboratory and cutting-edge imaging technologies. You will also benefit from the remarkable expertise in 3D organoid culture provided by the BioDiscovery Institute at the University of Nottingham.

您在我们多学科研究团队中的工作将促进我们对强调CRC启动和进展的机制的理解。它将有助于开发新的预防和治疗干预措施。你将专注于癌症研究中令人兴奋的部分，旨在剖析免疫系统、炎症和结直肠癌发展之间的相互作用。为了实现这一雄心勃勃的目标，你将接受培训，掌握一系列广泛的实验范式，包括转基因小鼠模型、上一代3D有机化合物培养和人类患者来源的外植体。后者是莱斯特大学首创的一种新颖的实验模型。你将结合传统的湿实验室技术，实验生物学的支柱，与现代尖端的转录和生物信息学分析相结合，以破译炎症对肠道上皮细胞的动态平衡及其形成肿瘤能力的影响。此外，为了加快实验数据向患者的转换，您将在人类患者来源的外植体培养中测试抗炎药物限制癌症增殖和侵袭性的能力。在博士期间，你将在莱斯特大学癌症研究中心工作，这是一个具有前瞻性的研究中心，拥有充满活力和热情的研究生研究社区。你将有机会接触到最先进的设施，如临床前研究设施，外植体实验室和尖端成像技术。您还将从诺丁汉大学生物发现研究所提供的3D有机物培养方面的非凡专业知识中受益。