Forebrain control of cardiovascular function: integrative and cellular mechanisms

前脑控制心血管功能：整合和细胞机制

• 批准号: nhmrc : 153812
• 负责人: E/Pr Roger Dampney
• 金额: $ 55.63万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/forebrain-control-cardiovascular-cellular-mechanisms/99358
• 关键词: Forebrain; control; cardiovascular; function; integrative

Blood pressure is controlled to a large extent by nerves, known as sympathetic nerves, that supply the heart and blood vessels. Measurements in humans have shown that the activity of sympathetic nerves is increased in a number of cardiovascular diseases, including heart failure and in many cases of high blood pressure. This has the effect of constricting blood vessels and increasing heart rate, which places an additional load on the heart which can cause damage to the heart. It is not known what causes this increased sympathetic activity, but one possibility is that it is due to the action of a circulating hormone called angiotensin, which acts on the brain, activating central nerve pathways which ultimately increase sympathetic activity. In this project we aim to test this hypothesis and thus help to unravel the mechanisms involved in the long term control of sympathetic activity and blood pressure.

血压在很大程度上是由交感神经控制的，交感神经是心脏和血管的供血神经。对人类的测量表明，交感神经的活动在许多心血管疾病中增加，包括心力衰竭和许多高血压病例。这具有收缩血管和增加心率的作用，这会对心脏造成额外的负荷，从而可能对心脏造成损害。目前尚不清楚是什么原因导致交感神经活动增加，但一种可能性是，这是由于一种称为血管紧张素的循环激素的作用，它作用于大脑，激活中枢神经通路，最终增加交感神经活动。在这个项目中，我们的目标是测试这一假设，从而帮助解开参与交感神经活动和血压的长期控制的机制。