Cardiovascular Development and Disease in the Young

描述（由申请人提供）： 先天性心血管畸形是美国最常见的出生缺陷。 随着越来越多的患有心血管疾病的儿科患者存活到成年，人们越来越认识到残留疾病的发生率很高，并对社会构成了巨大的健康负担。 复杂性心脏病患儿管理策略的复杂性以及对年轻人心脏病基础的了解，需要培养新一代的医生和科学家，致力于了解和改善心脏病患儿的护理。 先天性心脏病的病因是多因素的，遗传和环境因素起主要作用。 分子、生物化学和生物物理技术新方法的出现促进了心脏发育和疾病的遗传和环境调节的研究。 基因缺陷和介导这些基因的作用的独特分子途径的鉴定提供了一个机会，以开发诊断，预防和治疗策略，针对个人I心脏缺陷。 我们提出了一个为期2-3年的计划，其中儿科心脏病学的博士后学员将专注于心血管发育，心脏病遗传学，电生理学，生物化学或分子生物学的基础和转化方法。 我们纳入这些培训领域，因为我们需要培养一批科学家，他们可以通过翻译、转导和表型表达，从遗传决定因素中理解疾病。 为了提供这种培训，我们招募了具有基础科学学科专业知识的培训教师。 虽然没有一个受训者可以预期掌握所有的技术，该计划将深入教授每个受训者至少一个单独的学科，同样重要的是，学校的个人与其他学科的接口，并在翻译实验室结果到床边。

DESCRIPTION (provided by applicant): Congenital cardiovascular malformations are the most common birth defect in the US. As increasing numbers of pediatric patients with cardiovascular disease now survive into adulthood, there is a growing recognition that the incidence of residual disease is high and constitutes a substantial health burden to society. The complexity of management strategies in children with complex heart disease and the understanding of the basis of cardiac disease in the young require the development of a new generation of physicians and scientists dedicated to understanding and improving in the care of children with heart disease. Congenital heart disease is multifactorial in etiology with genetic and environmental factors playing a major role. The advent of new approaches in molecular, biochemical and biophysical technology has facilitated the study of the genetic and environmental regulation of cardiac development and disease. Identification of gene defects and the unique molecular pathways that mediate the effects of these genes provides an opportunity to develop diagnostic, preventive and therapeutic strategies tailored to individual I cardiac defects. We propose a 2-3 year program in which postdoctoral trainees in pediatric cardiology will I specialize in basic and translational approaches to cardiovascular development, genetics of cardiac disease, I electrophysiology, biochemistry or molecular biology. We incorporate these training areas because we need to develop a cadre of scientists who can carry the understanding of disease from genetic determinants, through translation, transduction and phenotypic expression. To provide this training, we have recruited to the training faculty individuals with expertise in basic science disciplines. Although no one trainee can be expected to master all the techniques, the program will teach at least one individual discipline in depth to each trainee, and equally importantly, school the individual in interfacing with other disciplines and in translating laboratory findings to the bedside.