Cardiovascular Development and Disease in the Young

描述(由申请人提供)： 先天性心血管畸形是美国最常见的出生缺陷。随着越来越多的患有心血管疾病的儿科患者存活到成年，人们越来越认识到残留病的发生率很高，对社会构成了巨大的健康负担。复杂心脏病儿童的管理策略的复杂性，以及对青少年心脏病基础的了解，需要培养新一代医生和科学家，致力于了解和改进心脏病儿童的护理。先天性心脏病的病因是多因素的，遗传和环境因素起主要作用。分子、生化和生物物理技术中新方法的出现促进了对心脏发育和疾病的遗传和环境调节的研究。识别基因缺陷和介导这些基因影响的独特分子途径为开发针对个体I型心脏缺陷的诊断、预防和治疗策略提供了机会。我们提出了一个2-3年的计划，在这个计划中，儿科心脏病学的博士后实习生将专门研究心血管发育、心脏病遗传学、电生理学、生物化学或分子生物学的基本和翻译方法。我们纳入这些培训领域是因为我们需要培养一支科学家队伍，他们能够通过翻译、转导和表型表达从遗传决定因素中理解疾病。为了提供这种培训，我们招募了在基础科学学科具有专业知识的个人到培训教员。虽然不可能期望一个受训者掌握所有的技术，但该计划将向每个受训者深入教授至少一个单独的学科，同样重要的是，学校将在与其他学科的互动和将实验室结果转化到床边方面向个人传授。

DESCRIPTION (provided by applicant): Congenital cardiovascular malformations are the most common birth defect in the US. As increasing numbers of pediatric patients with cardiovascular disease now survive into adulthood, there is a growing recognition that the incidence of residual disease is high and constitutes a substantial health burden to society. The complexity of management strategies in children with complex heart disease and the understanding of the basis of cardiac disease in the young require the development of a new generation of physicians and scientists dedicated to understanding and improving in the care of children with heart disease. Congenital heart disease is multifactorial in etiology with genetic and environmental factors playing a major role. The advent of new approaches in molecular, biochemical and biophysical technology has facilitated the study of the genetic and environmental regulation of cardiac development and disease. Identification of gene defects and the unique molecular pathways that mediate the effects of these genes provides an opportunity to develop diagnostic, preventive and therapeutic strategies tailored to individual I cardiac defects. We propose a 2-3 year program in which postdoctoral trainees in pediatric cardiology will I specialize in basic and translational approaches to cardiovascular development, genetics of cardiac disease, I electrophysiology, biochemistry or molecular biology. We incorporate these training areas because we need to develop a cadre of scientists who can carry the understanding of disease from genetic determinants, through translation, transduction and phenotypic expression. To provide this training, we have recruited to the training faculty individuals with expertise in basic science disciplines. Although no one trainee can be expected to master all the techniques, the program will teach at least one individual discipline in depth to each trainee, and equally importantly, school the individual in interfacing with other disciplines and in translating laboratory findings to the bedside.