Polymicrobial Interactions in Dental Plaque Formation

牙菌斑形成中的多种微生物相互作用

• 批准号: 7105985
• 负责人: Charles F Schachtele
• 金额: $ 5.8万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7105985
• 关键词: bacteria; biofilm; dental plaque; gene expression; genes; human

DESCRIPTION (provided by applicant): he proposed work is in response to NIH PA-04-093 involving NOVEL APPROACHES TO STUDY OLYMICROBIAL DISEASES. There is increasing evidence for the importance of polymicrobial infections in which microorganisms interact in a synergistic or inhibitory fashion, impacting on pathogenesis or the maintenance of health. The proposed studies involve very novel approaches for examining polymicrobial interactions known to occur in the development of pathogenic bacterial human dental plaque. Specifically, the studies will determine for the first time how factors involved in the virulence of and intercellular communication by specific oral bacteria are altered during the microbial interactions involved in dental plaque formation. Genomics and proteomics will be used to identify genes uniquely regulated during plaque formation. The utilization of continuous surfaces of primary plaque forming bacteria will allow detailed studies on the wide range of interbacterial interactions which occur during plaque development. Elucidation of the molecular details of plaque formation will enhance attempts to specifically reduce the pathogenic potential of biofilms known to be involved in the development of dental caries and the periodontal diseases.

描述(由申请人提供)：他建议的工作是响应NIH PA-04-093涉及研究OLYMICROBIAL疾病的新方法。越来越多的证据表明，多菌感染的重要性，其中微生物以协同或抑制的方式相互作用，影响发病或维持健康。拟议的研究涉及非常新颖的方法，用于检查已知在人类牙菌斑的致病细菌发展过程中发生的多个微生物的相互作用。具体地说，这些研究将首次确定参与特定口腔细菌毒力和细胞间通讯的因素在参与牙菌斑形成的微生物相互作用过程中是如何改变的。基因组学和蛋白质组学将被用来识别斑块形成过程中独特调节的基因。利用初级菌斑形成细菌的连续表面将允许详细研究在菌斑形成过程中发生的广泛的细菌间相互作用。阐明菌斑形成的分子细节将加强专门降低已知与龋齿和牙周病发展有关的生物膜的致病潜力的努力。