Lung Disease in Chinese Textile Workers

中国纺织工人的肺部疾病

• 批准号: 7148351
• 负责人: David C Christiani
• 金额: $ 33.97万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 2010-07-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7148351
• 关键词: China; atopy; byssinosis; cotton; endotoxins; enzyme linked immunosorbent assay; eosinophil; human subject; immunoglobulin E; immunologic skin test; industrial medicine; longitudinal human study; lung; occupational health /safety; questionnaires; respiratory disorder epidemiology; respiratory function; smoking

DESCRIPTION (provided by applicant): The Shanghai Textile Worker study is a competing continuation of R01 OH 02421. This proposal is designed to address unanswered questions regarding the respiratory health of workers chronically exposed to organic dust and endotoxin. Exposure to gram-negative bacterial endotoxin has been described in laboratory studies as producing acute respiratory symptoms and lung function change. To date, no other prospective epidemiologic study has addressed the relative contributions of cotton dust and endotoxin in producing both acute and chronic respiratory effects of workers. Although the study to date has elucidated new aspects of dust and endotoxin-related pulmonary responses, significant questions remain unanswered. In AIM 1, we will model changes in pulmonary function over 25 years for each subject (stage 1) and the association of these declines with dust and endotoxin (stage II). In AIM 2, we will examine the long-term effects of removal by retirement from exposure on respiratory health status. Finally, we have added an innovative AIM 3: to assess gene-environment interactions for acute and chronic pulmonary responses to exposure. The study population (a closed cohort) that has been followed since 1981 is unusually well-suited for epidemiologic study due to: low turnover; very low smoking prevalence among women workers; reliable baseline data; a suitable comparison group studied in identical fashion; excellent cooperation among industry officials, union and the collaborative research team; access to subjects who have retired or left the industry in disability; and cost-efficiency. The population includes 447 cotton textile and 472 silk textile workers first surveyed in 1981. Follow-up surveys were conducted in 1986,1992,1996, and 2001 with excellent participation. The proposed study is unique because exposure estimates for both dust and endotoxin over a 25-year period allow assessment of exposure response relationships for both dust and endotoxin for the full study interval. This cohort represents the largest prospective study of a working population exposed to vegetable dust and endotoxin. Results of this work are relevant to disease control in a wide variety of occupational settings, including textiles, grain processing, wood processing, animal confinement, sewage treatment, biotechnology, and clean-up of environmental disasters such as Hurricanes Katrina and Rita.

描述（由申请人提供）：上海纺织工人研究是R 01 OH 02421的竞争性延续。该提案旨在解决长期暴露于有机粉尘和内毒素的工人的呼吸系统健康方面尚未解决的问题。在实验室研究中，暴露于革兰氏阴性细菌内毒素被描述为产生急性呼吸道症状和肺功能变化。迄今为止，没有其他前瞻性流行病学研究已经解决了棉尘和内毒素在产生急性和慢性呼吸系统影响的工人的相对贡献。尽管迄今为止的研究已经阐明了粉尘和内毒素相关肺部反应的新方面，但重要问题仍未得到解答。在AIM 1中，我们将模拟每个受试者25年内肺功能的变化（第1阶段）以及这些下降与粉尘和内毒素的相关性（第II阶段）。在AIM 2中，我们将研究通过退休从暴露中去除对呼吸系统健康状况的长期影响。最后，我们增加了一个创新的目的3：评估急性和慢性肺暴露反应的基因-环境相互作用。研究人群自1981年以来一直在跟踪的一个非公开队列研究非常适合流行病学研究，原因是：更替率低;女工吸烟率很低;可靠的基线数据;以相同方式进行研究的适当比较组;行业官员、工会和协作研究小组之间的良好合作;可以接触退休或因残疾离开行业的受试者;和成本效益。人口包括447名棉纺织工人和472名丝绸纺织工人，首次调查于1981年。1986年、1992年、1996年和2001年进行了跟踪调查，参与率很高。拟定研究是独特的，因为25年期间粉尘和内毒素的暴露估计值允许评估整个研究间隔内粉尘和内毒素的暴露响应关系。该队列代表了对暴露于蔬菜粉尘和内毒素的工作人群进行的最大规模的前瞻性研究。这项工作的成果与各种职业环境中的疾病控制有关，包括纺织、谷物加工、木材加工、动物禁闭、污水处理、生物技术以及卡特里娜飓风和丽塔飓风等环境灾害的清理。