Imaging Unconditioned Fear

想象无条件的恐惧

• 批准号: 6989077
• 负责人: JEAN A KING
• 金额: $ 23.29万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-12-06 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6989077
• 关键词: Imaging; Unconditioned; Fear

DESCRIPTION (provided by applicant): The application of functional magnetic resonance imaging (fMRI) to visualize brain regions involved in emotion has considerably improved our understanding of human neurobiology. Progress has been much slower in applying this approach to conscious animals, due to obstacles such as immobility in the magnet and ability to perform tasks within a dark, narrow, horizontal space. These obstacles have been overcome with the recent invention of a small animal holding device for performing fMRI on fully awake rodents ranging in weight from 300 - 500g. Since fMRI research paradigms can now be performed in animals without injury or sacrifice, they provide new research opportunities for studies in areas where multiple time points in brain functioning can be assessed non-invasively, thereby allowing spatial as well as temporal mapping. This proposal describes a novel approach for mapping the fear response in the anaesthetized rat with fMRI. These studies will use fMRI to identify and monitor neuronal activation associated with fearfulness. For most animals, a primary fear-eliciting event is the possibility of being attacked by a predator. Consequently, predator stress is currently being simulated under laboratory conditions to trigger unconditioned (innate) fear responses in animals. Recent reports suggest that changes in neuroendocrine status of an animal may be central to fear response. In addition, drug intervention strategies have pointed to the inherent plasticity of the neural systems underlying this emotion. To test the hypothesis that unconditioned fear triggered by the scent of a predator will result in alterations in neuronal activation in a manner that reflect the neuroendocrine status and pharmacological response of an animal, we will utilize the technological advances for performing fMRI non-invasively in a conscious animal. The long-term goal of this research is to provide an understanding of the unique features of central mechanisms that regulate fearfulness and the impact of the neuroendocrine and neuropharmacological status on the processing of this emotion. Since fear experience by all animals, these studies may expand our understanding of anxiety and phobias in general.

描述（由申请人提供）：应用功能性磁共振成像（fMRI）来可视化涉及情感的大脑区域，大大提高了我们对人类神经生物学的理解。将这种方法应用到有意识的动物身上的进展要慢得多，因为存在一些障碍，比如磁铁中的不动性，以及在黑暗、狭窄、水平的空间中执行任务的能力。这些障碍已经被克服了，最近发明了一种小型动物抱着装置，用于对体重在300 - 500克之间的完全清醒的啮齿动物进行功能磁共振成像。由于fMRI研究范式现在可以在没有损伤或牺牲的情况下在动物身上进行，因此它们为可以非侵入性地评估大脑功能的多个时间点的研究领域提供了新的研究机会，从而允许空间和时间映射。本研究描述了一种用功能磁共振成像绘制麻醉大鼠恐惧反应的新方法。这些研究将使用功能磁共振成像来识别和监测与恐惧相关的神经元激活。对大多数动物来说，引起恐惧的主要事件是被捕食者攻击的可能性。因此，目前正在实验室条件下模拟捕食者压力，以触发动物的无条件（先天）恐惧反应。最近的报告表明，动物神经内分泌状态的变化可能是恐惧反应的核心。此外，药物干预策略指出了这种情绪背后神经系统的内在可塑性。为了验证由捕食者的气味引发的无条件恐惧会导致神经元激活的改变，这种改变反映了动物的神经内分泌状态和药理反应，我们将利用技术进步对有意识的动物进行无创功能磁共振成像。本研究的长期目标是了解调节恐惧的中枢机制的独特特征，以及神经内分泌和神经药理状态对这种情绪处理的影响。由于所有动物都有恐惧经历，这些研究可能会扩大我们对焦虑和恐惧症的理解。

项目成果

The role of 5-HT1A receptors in the behavioral responses associated with innate fear.

• DOI: 10.1037/0735-7044.122.3.611
• 发表时间: 2008-06
• 期刊: Behavioral neuroscience
• 影响因子: 1.9
• 作者: J. Shields;J. King

Anticorrelated resting-state functional connectivity in awake rat brain.

• DOI: 10.1016/j.neuroimage.2011.08.009
• 发表时间: 2012-01-16
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Liang, Zhifeng;King, Jean;Zhang, Nanyin
• 通讯作者: Zhang, Nanyin

Relationship of mindful awareness to neural processing of angry faces and impact of mindfulness training: A pilot investigation.

• DOI: 10.1016/j.pscychresns.2017.03.016
• 发表时间: 2017-06-30
• 期刊: Psychiatry research. Neuroimaging
• 作者: Lee AKW;Gansler DA;Zhang N;Jerram MW;King JA;Fulwiler C
• 通讯作者: Fulwiler C

Mapping resting-state brain networks in conscious animals.

• DOI: 10.1016/j.jneumeth.2010.04.001
• 发表时间: 2010-06-15
• 期刊: JOURNAL OF NEUROSCIENCE METHODS
• 影响因子: 3
• 作者: Zhang, Nanyin;Rane, Pallavi;Huang, Wei;Liang, Zhifeng;Kennedy, David;Frazier, Jean A.;King, Jean
• 通讯作者: King, Jean

Uncovering intrinsic connectional architecture of functional networks in awake rat brain.

• DOI: 10.1523/jneurosci.4557-10.2011
• 发表时间: 2011-03-09
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Liang Z;King J;Zhang N
• 通讯作者: Zhang N