Synthesis and measurements with multimodal sensing arrays

我们以前已经表明，交叉反应传感阵列是一个有效的工具，在复杂的混合物，包括血液，废水沃茨，饮料，如威士忌的研究。从交叉反应阵列中产生有意义结果的关键，也是我小组的主要关注领域，是开发和设计传感器化学，并对靶点和受体进行超分子理解。(1)在成功开发了基于分子和纳米颗粒传感器元件的生物分子和饮料阵列之后，（2，3）我们现在将注意力转向基于基底的传感器，更适合于仪器设计和需求点应用。(4)在与生物医学工程（克拉克）合作，我们将实现阵列的分子设计，用于检测血清中的肝脏疾病，以及废水沃茨中的污染物，但通过在光刻纳米结构上产生的表面等离子体共振（SPR）进行转导。将合成针对肝病的关键生物标志物或关键废水污染物（药物，农药，全氟化合物）的新型化学物质阵列，并将进行方法开发，以使传感器基板上的沉积，使用液体处理工具和测量。这将为未来研究开创性的高通量多区域SPR工具奠定基础。

We have previously shown that cross-reactive sensing arrays are a potent tool in the study of complex mixtures, including blood, waste waters, and beverages such as whisky. Key to generating meaningful results from a cross reactive array, and a main area of focus in my group, is the development and design of sensor chemistry with a supramolecular understanding of the targets and receptors.(1) Having successfully developed arrays for biomolecules and beverages based on molecular and nanoparticulate sensor elements,(2,3) we now turn our attention to substrate-based sensors, more suited to instrumental design and point-of-need applications.(4) In collaboration with Biomedical Engineering (Clark) we will implement arrays with molecular designs for sensing liver disease in serum, and pollutants in waste waters, but transduced by surface-plasmon resonance (SPR) generated on lithographic nanostructures. Novel arrays of chemistries will be synthesised that target key biomarkers of liver disease, or key waste-water pollutants (pharmaceuticals, pesticides, perfluorinated compounds), and methodology development will be undertaken to enable deposition on sensor substrates, using liquid handling tools, and measurement. This will form the basis for a ground-breaking high-throughput multi-region SPR tool for future studies.