Synthesis and measurements with multimodal sensing arrays

我们之前已经证明，交叉反应传感阵列是研究复杂混合物的有效工具，包括血液、废水和威士忌等饮料。交叉反应阵列产生有意义结果的关键，也是我所在团队的一个主要重点领域，是对目标和受体的超分子理解的传感器化学的开发和设计。(1)成功开发了基于分子和纳米颗粒传感器元件的生物分子和饮料阵列，(2，3)现在我们将注意力转向基于衬底的传感器，更适合仪器设计和按需应用。(4)与生物医学工程(Clark)合作，我们将实施具有分子设计的阵列，用于检测血清中的肝病和废水中的污染物，但通过表面等离子共振(SPR)产生的光刻纳米结构进行转换。将合成针对肝病关键生物标记物或关键废水污染物(药品、杀虫剂、全氟化合物)的新型化学物质阵列，并将进行方法学开发，以便使用液体处理工具和测量在传感器衬底上沉积。这将为未来研究的突破性高通量多区域SPR工具奠定基础。

We have previously shown that cross-reactive sensing arrays are a potent tool in the study of complex mixtures, including blood, waste waters, and beverages such as whisky. Key to generating meaningful results from a cross reactive array, and a main area of focus in my group, is the development and design of sensor chemistry with a supramolecular understanding of the targets and receptors.(1) Having successfully developed arrays for biomolecules and beverages based on molecular and nanoparticulate sensor elements,(2,3) we now turn our attention to substrate-based sensors, more suited to instrumental design and point-of-need applications.(4) In collaboration with Biomedical Engineering (Clark) we will implement arrays with molecular designs for sensing liver disease in serum, and pollutants in waste waters, but transduced by surface-plasmon resonance (SPR) generated on lithographic nanostructures. Novel arrays of chemistries will be synthesised that target key biomarkers of liver disease, or key waste-water pollutants (pharmaceuticals, pesticides, perfluorinated compounds), and methodology development will be undertaken to enable deposition on sensor substrates, using liquid handling tools, and measurement. This will form the basis for a ground-breaking high-throughput multi-region SPR tool for future studies.