Service Core 2: Biomolecular Resource

服务核心2：生物分子资源

• 批准号: 6872745
• 负责人: ALEXANDER none KUROSKY
• 金额: $ 28万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6872745
• 关键词: bacterial proteins; biochemistry; biomedical facility; environmental health; gene expression; mass spectrometry; nucleic acid sequence; oxidative stress; peptide chemical synthesis; protein purification; proteomics

Description (provided by applicant): The Biomolecular Resource Facility (BRF) is a newly re-organized and expanded infrastructure research service at UTMB that includes five component cores largely dedicated to the population and/or analysis of proteins and peptides. The Biomolecular Resource Facility Core refers to that component of the BRF that is supported by the NIEHS Center. The five component cores are: 1) Mass Spectrometry, 2) Peptide Synthesis, 3) Protein Chemistry, 4) Protein Expression and Purification, and 5) Proteomics. In the past funding period this NIEHS service core was called the Protein Chemistry and Purification Core Facility. Major new additions include a Proteomics Core and a Mass Spectrometry Core, as well as several major items of equipment obtained from three NIH/NCRR equipment grants (A. Kurosky, principal investigator). Re-organization has centralized the administrative structure of the facility, providing a higher efficiency of operation and greater convenience to NIEHS investigators; 16 of the 18 services offered have NIEHS usages ranging from 5% to 75% of the facility's total UTMB usage, depending on the service. This amount of usage represents an excellent return on NIEHS. investment, which is currently about 10% of the BRF.s total direct operating costs. The core director, Dr. Alex Kurosky, has over 30 years of experience relating to protein structure and function and to genetics. The BRF has been instrumental in UTMB's receipt of several major proteomics funding awards from NIH, including a major NHLBI Proteomics center to Dr. Kurosky. The resulting new capabilities in turn enhance the value of the BRF to NIEHS Center investigators. Continued support for this expanded and re-organized core will be very important to the NIEHS Center, especially to provide our Center investigators much-need access to proteomics and mass spectrometry technologies.

描述（由申请人提供）：生物分子资源设施（BRF）是UTMB新近重组和扩展的基础设施研究服务，包括五个组件核心，主要用于蛋白质和肽的种群和/或分析。生物分子资源设施核心是指由NIEHS中心支持的BRF的组成部分。五个组成核心是：1)质谱，2)肽合成，3)蛋白质化学，4)蛋白质表达和纯化，5)蛋白质组学。在过去的资助时期，NIEHS服务核心被称为蛋白质化学和纯化核心设施。新增的主要功能包括蛋白质组学核心和质谱核心，