TAS::75 0872::TAS UTMB-NHLBI PROTEOMIC CENTER FOR AIRWAY INFLAMMATION

塔斯马尼亚州::75 0872::塔斯马尼亚州 UTMB-NHLBI 气道炎症蛋白质组学中心

• 批准号: 8320843
• 负责人: ALEXANDER none KUROSKY
• 金额: $ 214.09万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2015-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8320843
• 关键词: Asthma; Biological Markers; Cells; Chronic Obstructive Airway Disease; Development; Diagnosis; Diagnostic; Disease; Goals; Hypersensitivity; Infection; Lead; Leukocytes; Measures; Medical; National Heart, Lung, and Blood Institute; Pathway interactions; Peptides; Post-Translational Protein Processing; Proteins; Proteome; Proteomics; Severity of illness; Structure of parenchyma of lung; Technology; Texas; Therapeutic Intervention; Tissues; Universities; airway inflammation; base; clinical application; design; innovation; new technology; outcome forecast; prognostic; protein expression; respiratory virus; stressor; translational study

The goal of the University of Texas Medical Branch Proteomics Center is to utilize comprehensive and innovative proteomic strategies to investigate protein expression levels and post-translational modifications in cells, tissues, and biofluids associated with airway inflammation related to allergy, asthma, COPD, and respiratory viruses. These studies will lead to the development of new technologies to provide a mechanistic and functional understanding of proteomes impacting on airway inflammation, and to identify important biomarkers for diagnosis and prognosis.

德克萨斯大学医学分支蛋白质组学中心的目标是利用全面和创新的蛋白质组学策略来研究与过敏、哮喘、COPD和呼吸道病毒相关的气道炎症相关的细胞、组织和生物流体中的蛋白质表达水平和翻译后修饰。这些研究将导致新技术的发展，以提供对影响气道炎症的蛋白质组的机制和功能的理解，并确定用于诊断和预后的重要生物标志物。