MASS SPECTROMETER

请求为加尔维斯顿的得克萨斯大学医学分支（UTMB）的多功能、高性能质谱仪提供支持。该提案中包含的是购买Finnigan LCQ-DECA离子阱质谱仪的请求，用于分析大型健康科学中心研究社区中产生的宽光谱样品。质谱仪将被安置在UTMB蛋白质化学实验室内，该实验室是自1975年以来一直为UTMB研究界服务的核心设施。要求的仪器将由9名NIH资助的研究人员组成的主要小组在至少75%的时间内使用。预计由7名NIH资助的研究人员组成的代表性小型用户组将在剩余的可用时间内使用该仪器。这些研究人员共同代表了一个由基础和临床研究人员组成的多学科小组，他们正在研究对疾病过程产生重大影响的生物医学科学的基本方面。健康环境卫生、神经遗传性疾病、眼病、糖尿病、免疫力、细菌性疾病和疼痛。用户群涵盖多学科研究领域，包括生物化学、遗传学、细胞生物学、微生物学、外源性物质、免疫学、病理学、神经学、环境毒理学、药理学和分子生物学。这些研究人员的资金总额为34项NIH赠款，包括项目，进入和RO 1赠款，他们每年的NIH支持总额约为520万美元。获得所要求的仪器将大大提高这些调查人员进行其正在进行的研究的能力，而且预计将在未来扩大研究机会，以提高生产力水平。

Support is requested for a versatile, high performance mass spectrometer at the University of Texas Medical Branch (UTMB) in Galveston. Contained in this proposal is a request to purchase a Finnigan LCQ- DECA ion trap mass spectrometer for the analysis of a wide spectrum of samples generated in the research community of a large Health Science Center. The mass spectrometer will be housed physically and administratively within the UTMB Protein Chemistry Laboratory, a core facility that has served the UTMB research community since 1975. The requested instrumentation will be utilized by a major group of nine NIH- funded investigators for at least 75% of the time. A representative minor user group of 7 NIH-funded researchers is expected to use the instrumentation for the remainder of the available time. Together these investigators represent a multi-disciplinary group of basic and clinical researchers who are inquiring into the fundamental aspects of biomedical sciences that significantly impact on disease process. Health environmental health, neurogenetic disease, eye disease, diabetes, immunity, bacterial diseases, and pain. The user groups encompass multi- disciplinary research areas that include biochemistry, genetics, cell biology, microbiology, xenobiotics, immunology, pathology, neurology, environmental toxicology, pharmacology, and molecular biology. The combined funding of these investigators number 34 NIH grants, including program project, enter, and RO1 grants, and their total annual NIH support is about $5.2 million dollars. Acquisition of the requested instrumentation will significantly enhance the ability of these investigators to conduct their ongoing research and moreover is expected to extend research opportunities in the future to higher productivity levels.