Dry-reagent methods for detection of iodine in urine

项目描述（由申请人提供）：本项目的长期目标是开发快速、准确、可靠的尿碘测定方法和检测试剂盒。方法和测试试剂盒必须便宜且易于使用，以便在现场条件下进行碘的测定。开发干试剂试纸条法检测食盐中的碘。试纸法将通过快速“浸读”程序检测碘。当测试条浸入测试样品时，指示垫的颜色会根据碘水平而变化。不需要单独的化学品供应，除了包含在指示垫。不需要耗时的试剂工作，如称重，混合，体积测量等。今天，全世界约有16亿人仍然生活在缺碘症并发症的威胁之下，这些并发症包括：先天性黏液性水肿（克汀病）、脑损伤、甲状腺功能减退和甲状腺肿。由于碘缺乏症可以通过补充碘盐轻松治愈，因此对缺碘地区的人群进行筛查对于有效规划、实施和改进缺碘症预防措施至关重要。筛查人群中碘缺乏和碘摄入量的最佳方法是测量尿液中的碘含量。筛查对全世界所有贫穷、偏远和服务不足的社区都非常重要；这在发达国家也很重要。为了控制缺碘症，需要开发新的、快速、准确、可靠和廉价的尿液碘测量检测试剂盒，以取代目前使用的基于实验室的方法。

DESCRIPTION (provided by applicant): The long term goal of this project is to develop rapid, accurate and reliable methods and test kits for iodine determination in urine. The methods and test kits must be inexpensive and easy-to-use to perform determinations of iodine under field conditions. Dry-reagent test strip methods for detection of iodine in salt will be developed. The test strip method will detect iodine by a fast "dip and read" procedure. When the test strips are dipped in the tested sample, the color of the indicator pad will change in accordance with iodine levels. No separate chemical supply will be needed except for that included in the indicator pad. No time-consuming work with reagents such as weighing, mixing, volume measurement, etc. will be required. Today, about 1.6 billion people worldwide still live under the threat of IDD complications that include: congenital myxedema (cretinism), brain damage, hypothyroidism and goiter. Because iodine deficiency could be readily cured by iodized salt supplementation, screening of the population in iodine-deficient regions is critical for effective planning, implementation and improvement of IDD-preventive measures. The best way to screen for iodine deficiency and intake in populations is to measure iodine in urine. The screening is highly important for all poor, remote and underserved communities worldwide; it is also important in the developed world. In order to control IDD new, rapid, accurate, reliable and inexpensive iodine measurement test kits for urine need to be developed to replace currently used laboratory based methods.