Dry-reagent methods for detection of iodine in urine

描述(申请人提供)：该项目的长期目标是开发快速、准确和可靠的尿碘检测方法和检测试剂盒。方法和检测试剂盒必须便宜且易于使用，以便在现场条件下进行碘的测定。将发展盐中碘的干试剂试纸检测方法。试纸法将通过快速的“浸泡和读取”程序检测碘。当试纸浸泡在被测样品中时，指示器垫的颜色会随着碘水平的变化而变化。除指示板中包含的化学品外，不需要单独的化学品供应。不需要耗时的试剂工作，如称重、混合、体积测量等。今天，全世界约有16亿人仍然生活在缺碘并发症的威胁下，这些并发症包括：先天性粘液水肿(克汀病)、脑损伤、甲状腺机能减退和甲状腺肿。由于补碘食盐很容易治愈缺碘，因此对缺碘地区的人口进行筛查对于有效规划、实施和改进预防碘缺乏病措施至关重要。筛查人群碘缺乏和摄入量的最好方法是测量尿碘。筛查对全世界所有贫穷、偏远和服务不足的社区非常重要；在发达国家也很重要。为了控制碘缺乏病，需要开发新的、快速、准确、可靠和廉价的尿碘检测试剂盒，以取代目前使用的实验室方法。

DESCRIPTION (provided by applicant): The long term goal of this project is to develop rapid, accurate and reliable methods and test kits for iodine determination in urine. The methods and test kits must be inexpensive and easy-to-use to perform determinations of iodine under field conditions. Dry-reagent test strip methods for detection of iodine in salt will be developed. The test strip method will detect iodine by a fast "dip and read" procedure. When the test strips are dipped in the tested sample, the color of the indicator pad will change in accordance with iodine levels. No separate chemical supply will be needed except for that included in the indicator pad. No time-consuming work with reagents such as weighing, mixing, volume measurement, etc. will be required. Today, about 1.6 billion people worldwide still live under the threat of IDD complications that include: congenital myxedema (cretinism), brain damage, hypothyroidism and goiter. Because iodine deficiency could be readily cured by iodized salt supplementation, screening of the population in iodine-deficient regions is critical for effective planning, implementation and improvement of IDD-preventive measures. The best way to screen for iodine deficiency and intake in populations is to measure iodine in urine. The screening is highly important for all poor, remote and underserved communities worldwide; it is also important in the developed world. In order to control IDD new, rapid, accurate, reliable and inexpensive iodine measurement test kits for urine need to be developed to replace currently used laboratory based methods.