High Resolution and High Contrast Near-IR Imaging of the Human Fundus

人类眼底的高分辨率和高对比度近红外成像

• 批准号: 7108831
• 负责人: Nathan Doble
• 金额: $ 9.99万
• 依托单位: IRIS AO, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-04 至 2008-08-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7108831
• 关键词: aging; clinical research; eye; fluorescence; human; stroke; vision

DESCRIPTION (provided by applicant): This Phase I SBIR will prove the feasibility of a design for a confocal scanning laser ophthalmoscope (cSLO) that can take high-resolution in-vivo images of the human eye. This cSLO will use long wavelength sources to permit deeper imaging than conventional cSLOs. More importantly, the system will incorporate micro-electro-mechanical adaptive optics (MEMS-AO) to dynamically correct the optical aberrations that currently preclude high-resolution imaging of these deeper layers. By combining these 2 technologies, it will be possible for the first time to observe, in vivo, currently irresolvable features of the human eye. Because many degenerative retinal diseases originate in these deep layers, such a system promises to boost our understanding of and ability to treat a host of debilitating eye diseases. After construction of a working prototype during Phase II, Iris AO will refine and test it by focusing primarily on age-related macular degenereration (AMD). AMD is particularly appropriate for study because it is first manifest deep in the eye, far beyond the reach of conventional systems and because it is the leading cause of legal blindness in adults over age 60. Phase I research will focus on (1) adaptive optics (AO) subsystem optimization deformable mirror control, (2) MEMS mirror coating and packaging, (3) wide field imaging and fixation development, (4) experimental long wavelength imaging, (5) detailed ZEMAX optical system design. Phase II prototyping and Phase III commercialization will result in a general purpose, deep-imaging cSLO. Eye disease blinds thousands of Americans and degrades the eye sight of millions more. Under this proposal, new imaging technology will be developed to fight debilitating eye disease resulting in earlier disease detection, faster drug clinical trials, and better medical understanding.

描述(申请人提供)：这项第一阶段的SBIR将证明共焦扫描激光检眼镜(CSLO)设计的可行性，该激光检眼镜可以拍摄高分辨率的人眼活体图像。这种cSLO将使用长波长源，以实现比传统cSLO更深的成像。更重要的是，该系统将纳入微电子机械自适应光学系统(MEMS-AO)，以动态校正目前无法对这些较深层进行高分辨率成像的光学像差。通过将这两项技术结合起来，将有可能首次在活体内观察到目前无法分辨的人眼特征。由于许多退行性视网膜疾病起源于这些深层，这样的系统有望提高我们对一系列令人衰弱的眼病的理解和治疗能力。在第二阶段建造了一个工作原型后，Iris AO将通过主要关注年龄相关性黄斑变性(AMD)来改进和测试它。AMD特别适合研究，因为它首先在眼睛深处显现，远远超出传统系统的覆盖范围，而且它是60岁以上成年人法定失明的主要原因。第一阶段的研究将集中在(1)自适应光学(AO)子系统优化变形反射镜控制，(2)MEMS反射镜镀膜和封装，(3)广视场成像和固定开发，(4)实验长波成像，(5)详细的ZEMAX光学系统设计。第二阶段的原型和第三阶段的商业化将导致通用的深度成像cSLO。眼疾使数以千计的美国人失明，并使数百万人的视力下降。根据这项提议，将开发新的成像技术来对抗使人衰弱的眼部疾病，从而更早地发现疾病，更快地进行药物临床试验，并更好地了解医学。