Field Portable Instrument for Iodide Analysis

用于碘化物分析的现场便携式仪器

• 批准号: 7156290
• 负责人: John W Birks
• 金额: $ 10万
• 依托单位: 2B TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7156290
• 关键词: angiotensin /renin /aldosterone hypertension; diagnosis design /evaluation; environmental health; field study; human subject; iodination; iodine; malnutrition; mass screening; nutrition disorder diagnosis; nutrition related tag; rapid diagnosis; salts; urine

DESCRIPTION (provided by applicant): Project Summary/Abstract: Iodide deficiency disorders (IDDs) have been identified by the World Health Organization as a serious global health problem affecting 740 million people in 130 countries. Iodine deficiency is the most common cause of preventable brain damage, with nearly 50 million people suffering some degree of IDD-related brain damage. IDD is preventable and treatable by iodization of table salt. Identification of individuals suffering from IDD and populations at risk requires the development of an instrument capable of measuring iodine in urine and table salt. We propose to develop a small, lightweight, inexpensive instrument to achieve quantification of iodine. The Rapid Iodine Analyzer (RIA) will allow measurement of iodine present as either iodide or iodate. The instrument will be based on a novel and proprietary detection method described in the text of the proposal. It will be highly automated and will require very little sample preparation. The portable instrument is expected to have a limit of detection of ~1 ppb and to be free of interferences. Thus, the sensitivity will be adequate to diagnose patients as having moderate (20-49 ppb) or severe iodine deficiency (<20 ppb), as well as those having normal (100-199 ppb) or excess iodine (>300 ppb) in their urine. Because of its low cost (~$2,000 retail), portability (<5 lb), and low power requirements (~2 watt), the iodine instrument will be highly useful for assessing iodine deficiency in populations in remote locations around the globe and for testing for the presence of iodine additives to salts dispensed in those regions. Project Narrative(Relevance): A high sensitive (.~ 1ppb) portable instrument will be developed for the measurement of iodide and iodate in urine and table salt. The Rapid Iodine Analyzer will be highly useful in addressing the problem of iodine deficiency disorder currently affecting 740 million people in 130 countries.

描述(申请人提供)：项目摘要/摘要：碘缺乏症(IDDS)已被世界卫生组织确定为一个严重的全球健康问题，影响着130个国家的7.4亿人。缺碘是可预防的脑损伤最常见的原因，近5000万人遭受不同程度的与缺碘相关的脑损伤。碘缺乏病可以通过食盐加碘来预防和治疗。识别患有碘缺乏病的个人和处于危险中的人群需要开发一种能够测量尿碘和食盐中碘的仪器。我们建议开发一种小型、轻便、廉价的仪器来实现碘的定量。快速碘分析仪(RIA)将允许测量碘以碘化物或碘酸盐的形式存在。该仪器将基于提案案文中描述的一种新颖和专有的检测方法。这将是高度自动化的，只需要很少的样品准备。该便携式仪器的检测下限为~1 ppb，且不受干扰。因此，灵敏度将足以诊断为中度(20-49 ppb)或重度碘缺乏(&lt；20 ppb)的患者，以及那些尿碘正常(100-199 ppb)或过量(&gt；300 ppb)的患者。由于其低成本(约2,000美元零售)、便携性(5磅)和低功率要求(约2瓦)，该碘量仪将非常有助于评估全球偏远地区人口的碘缺乏症，并用于测试这些地区分发的食盐中是否存在碘添加剂。项目简介(相关)：将开发一种高灵敏度(.~1 ppb)便携式仪器，用于测量尿液和食盐中的碘和碘酸盐。快速碘分析仪将在解决目前影响130个国家7.4亿人的缺碘症问题方面发挥很大作用。