Field Portable Instrument for Iodide Analysis

描述（由申请人提供）：项目摘要/摘要：碘缺乏病（IDDs）已被世界卫生组织确定为一个严重的全球健康问题，影响130个国家的7.4亿人。缺碘是可预防的脑损伤的最常见原因，近5000万人患有某种程度的与缺碘有关的脑损伤。缺碘症可以通过食盐加碘来预防和治疗。要查明缺碘症患者和高危人群，就需要研制一种能够测量尿和食盐中碘含量的仪器。我们建议开发一种体积小、重量轻、价格便宜的仪器来实现碘的定量。快速碘分析仪（RIA）将允许测量以碘化物或碘酸盐形式存在的碘。该仪器将以提案正文中所述的一种新颖的专有检测方法为基础。它将是高度自动化的，将需要很少的样品制备。预计便携式仪器的检测限约为1 ppb，且无干扰。因此，灵敏度将足以诊断患有中度（20-49 ppb）或重度碘缺乏症（<20 ppb）的患者，以及尿中碘正常（100-199 ppb）或过量（>300 ppb）的患者。由于其低成本（零售价约2，000美元）、便携性（<5磅）和低功率要求（约2瓦），碘仪器将非常适用于评估地球仪周围偏远地区人群的碘缺乏症，并用于检测这些地区分发的盐中是否存在碘添加剂。项目叙述（相关性）：高度敏感（.~ 1 ppb）的便携式仪器，用于测定尿和食盐中的碘化物和碘酸盐。快速碘分析仪将非常有助于解决目前影响130个国家7.4亿人的缺碘症问题。

DESCRIPTION (provided by applicant): Project Summary/Abstract: Iodide deficiency disorders (IDDs) have been identified by the World Health Organization as a serious global health problem affecting 740 million people in 130 countries. Iodine deficiency is the most common cause of preventable brain damage, with nearly 50 million people suffering some degree of IDD-related brain damage. IDD is preventable and treatable by iodization of table salt. Identification of individuals suffering from IDD and populations at risk requires the development of an instrument capable of measuring iodine in urine and table salt. We propose to develop a small, lightweight, inexpensive instrument to achieve quantification of iodine. The Rapid Iodine Analyzer (RIA) will allow measurement of iodine present as either iodide or iodate. The instrument will be based on a novel and proprietary detection method described in the text of the proposal. It will be highly automated and will require very little sample preparation. The portable instrument is expected to have a limit of detection of ~1 ppb and to be free of interferences. Thus, the sensitivity will be adequate to diagnose patients as having moderate (20-49 ppb) or severe iodine deficiency (<20 ppb), as well as those having normal (100-199 ppb) or excess iodine (>300 ppb) in their urine. Because of its low cost (~$2,000 retail), portability (<5 lb), and low power requirements (~2 watt), the iodine instrument will be highly useful for assessing iodine deficiency in populations in remote locations around the globe and for testing for the presence of iodine additives to salts dispensed in those regions. Project Narrative(Relevance): A high sensitive (.~ 1ppb) portable instrument will be developed for the measurement of iodide and iodate in urine and table salt. The Rapid Iodine Analyzer will be highly useful in addressing the problem of iodine deficiency disorder currently affecting 740 million people in 130 countries.