Field Portable Instrument for Iodide Analysis

项目摘要/摘要：碘缺乏症（IDDs）已被世界卫生组织确定为影响130个国家7.4亿人的严重全球健康问题。缺碘是造成可预防脑损伤的最常见原因，近5000万人患有与缺碘症相关的不同程度的脑损伤。碘缺乏病可以通过食盐加碘来预防和治疗。要确定缺碘症患者和高危人群，就需要研制一种能够测量尿液和食盐中的碘的仪器。我们建议开发一种体积小、重量轻、价格低廉的仪器来实现碘的定量。快速碘分析仪（RIA）将允许测量碘存在的碘化物或碘酸盐。该仪器将基于提案文本中描述的一种新颖的专有检测方法。这将是高度自动化的，将需要很少的样品准备。该便携式仪器的检出限预计为~ 1ppb，且无干扰。因此，灵敏度将足以诊断中度（20- 49ppb）或重度碘缺乏（< 20ppb）的患者，以及尿中碘正常（100- 199ppb）或过量（bbb300 ppb）的患者。由于其低成本（零售价约为2,000美元），便携性（<5磅）和低功率要求（约2瓦），碘仪器将非常有用，可用于评估全球偏远地区人口的碘缺乏症，并可用于测试在这些地区分发的盐中是否存在碘添加剂。项目叙述（相关性）：一个高度敏感的(。~ 1ppb)便携式仪器，用于测定尿液和食盐中的碘化物和碘酸盐。快速碘分析仪将对解决目前影响130个国家7.4亿人的缺碘症问题非常有用。

DESCRIPTION (provided by applicant): Project Summary/Abstract: Iodide deficiency disorders (IDDs) have been identified by the World Health Organization as a serious global health problem affecting 740 million people in 130 countries. Iodine deficiency is the most common cause of preventable brain damage, with nearly 50 million people suffering some degree of IDD-related brain damage. IDD is preventable and treatable by iodization of table salt. Identification of individuals suffering from IDD and populations at risk requires the development of an instrument capable of measuring iodine in urine and table salt. We propose to develop a small, lightweight, inexpensive instrument to achieve quantification of iodine. The Rapid Iodine Analyzer (RIA) will allow measurement of iodine present as either iodide or iodate. The instrument will be based on a novel and proprietary detection method described in the text of the proposal. It will be highly automated and will require very little sample preparation. The portable instrument is expected to have a limit of detection of ~1 ppb and to be free of interferences. Thus, the sensitivity will be adequate to diagnose patients as having moderate (20-49 ppb) or severe iodine deficiency (<20 ppb), as well as those having normal (100-199 ppb) or excess iodine (>300 ppb) in their urine. Because of its low cost (~$2,000 retail), portability (<5 lb), and low power requirements (~2 watt), the iodine instrument will be highly useful for assessing iodine deficiency in populations in remote locations around the globe and for testing for the presence of iodine additives to salts dispensed in those regions. Project Narrative(Relevance): A high sensitive (.~ 1ppb) portable instrument will be developed for the measurement of iodide and iodate in urine and table salt. The Rapid Iodine Analyzer will be highly useful in addressing the problem of iodine deficiency disorder currently affecting 740 million people in 130 countries.